Zobrazeno 1 - 10
of 3 622
pro vyhledávání: '"A. G. Chapuis"'
Autor:
Jung Hyun Lee, Justin Daho Lee, Kelly Paulson, Valentin Voillet, Andre Berndt, Candice Church, Kristina Lachance, Song Y. Park, Naomi K. Yamamoto, Elizabeth A. Cromwell, Raphael Gottardo, Aude G. Chapuis, Paul Nghiem
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23521- (2024)
Approximately 50% of Merkel cell carcinoma (MCC) patients facing this highly aggressive skin cancer initially respond positively to PD-1-based immunotherapy. Nevertheless, the recurrence of MCC post-immunotherapy emphasizes the pressing need for more
Externí odkaz:
https://doaj.org/article/6b3e03a0dc0c42df8e077d2b0c8553fb
Autor:
Michael Schreiber
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 64:433-434
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f97afb634508d3d57c05bcba71d648b
https://doi.org/10.1107/s0108767308009343
https://doi.org/10.1107/s0108767308009343
Autor:
André Authier
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 62:464-464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::555b988ca80e1536f7bf8358a77d3dda
https://doi.org/10.1107/s010876730602616x
https://doi.org/10.1107/s010876730602616x
Autor:
K. G. Paulson, V. Voillet, M. S. McAfee, D. S. Hunter, F. D. Wagener, M. Perdicchio, W. J. Valente, S. J. Koelle, C. D. Church, N. Vandeven, H. Thomas, A. G. Colunga, J. G. Iyer, C. Yee, R. Kulikauskas, D. M. Koelle, R. H. Pierce, J. H. Bielas, P. D. Greenberg, S. Bhatia, R. Gottardo, P. Nghiem, A. G. Chapuis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel me
Externí odkaz:
https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb3
Autor:
Miranda C. Lahman, Thomas M. Schmitt, Kelly G. Paulson, Nathalie Vigneron, Denise Buenrostro, Felecia D. Wagener, Valentin Voillet, Lauren Martin, Raphael Gottardo, Jason Bielas, Julie M. McElrath, Derek L. Stirewalt, Era L. Pogosova-Agadjanyan, Cecilia C. Yeung, Robert H. Pierce, Daniel N. Egan, Merav Bar, Paul C. Hendrie, Sinéad Kinsella, Aesha Vakil, Jonah Butler, Mary Chaffee, Jonathan Linton, Megan S. McAfee, Daniel S. Hunter, Marie Bleakley, Anthony Rongvaux, Benoit J. Van den Eynde, Aude G. Chapuis, Philip D. Greenberg
Publikováno v:
Sci Transl Med
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab8910054866ad4b7f3c2247308f44
https://doi.org/10.1126/scitranslmed.abg8070
https://doi.org/10.1126/scitranslmed.abg8070
Autor:
David M. Koelle, Paul Nghiem, Shailender Bhatia, Aude G. Chapuis, Kelly G. Paulson, Alexander L. Greninger, Hong Xie, Maclean M. Cook, Aric Colunga, Olga K. Afanasiev, Jayasri G. Iyer, Dafina Ibrani, Rima M. Kulikauskas, Candice D. Church, Mariliis Ott, Lichen Jing
Merkel cell carcinoma (MCC) is often caused by persistent expression of Merkel cell polyomavirus (MCPyV) T-antigen (T-Ag). These non-self proteins comprise about 400 amino acids (AA). Clinical responses to immune checkpoint inhibitors, seen in about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9a294b7b6bf30cd0808d965f016936
https://doi.org/10.1158/2326-6066.c.6550341
https://doi.org/10.1158/2326-6066.c.6550341
Autor:
David M. Koelle, Paul Nghiem, Shailender Bhatia, Aude G. Chapuis, Kelly G. Paulson, Alexander L. Greninger, Hong Xie, Maclean M. Cook, Aric Colunga, Olga K. Afanasiev, Jayasri G. Iyer, Dafina Ibrani, Rima M. Kulikauskas, Candice D. Church, Mariliis Ott, Lichen Jing
Sup Tables 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837b363fa3c7ff4968d02a275139c5b9
https://doi.org/10.1158/2326-6066.22543638
https://doi.org/10.1158/2326-6066.22543638
Autor:
David M. Koelle, Paul Nghiem, Shailender Bhatia, Aude G. Chapuis, Kelly G. Paulson, Alexander L. Greninger, Hong Xie, Maclean M. Cook, Aric Colunga, Olga K. Afanasiev, Jayasri G. Iyer, Dafina Ibrani, Rima M. Kulikauskas, Candice D. Church, Mariliis Ott, Lichen Jing
Sup Figures 1-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4114aa56b2c3c1064d3e8347f1a85b67
https://doi.org/10.1158/2326-6066.22543641.v1
https://doi.org/10.1158/2326-6066.22543641.v1
Autor:
Paul Nghiem, Cassian Yee, David M. Koelle, Cindy Desmarais, Ted Gooley, Kendall C. Shibuya, Shailender Bhatia, Heather L. Sloan, Ilana M. Roberts, Ivy Lai, Joo Ha Hwang, Upendra Parvathaneni, Kelly G. Paulson, Jayasri G. Iyer, Olga K. Afanasiev, Aude G. Chapuis
PDF file - 738K, Supplementary Fig. S1: Detection of MCPyV-specific CD8 T cells among tumor infiltrating lymphocytes (TIL) from the primary MCC tumor (left) and PBMC (right). Cells were stained with A24/MCPyV.LT.92-101 tetramer and CD8. Supplementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db7e984993205f4f853e71a39c28e16
https://doi.org/10.1158/2326-6066.22535900.v1
https://doi.org/10.1158/2326-6066.22535900.v1
Autor:
Paul Nghiem, Cassian Yee, David M. Koelle, Cindy Desmarais, Ted Gooley, Kendall C. Shibuya, Shailender Bhatia, Heather L. Sloan, Ilana M. Roberts, Ivy Lai, Joo Ha Hwang, Upendra Parvathaneni, Kelly G. Paulson, Jayasri G. Iyer, Olga K. Afanasiev, Aude G. Chapuis
Merkel cell carcinoma (MCC) is an aggressive skin cancer that typically requires the persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins that can serve as ideal immunotherapeutic targets. Several immune evasion mechanisms are activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31668861506a1e7777cf2fede8524bc
https://doi.org/10.1158/2326-6066.c.6547979.v1
https://doi.org/10.1158/2326-6066.c.6547979.v1