Zobrazeno 1 - 10
of 10
pro vyhledávání: '"A. G. Bozward"'
Autor:
Scott P. Davies, Vincenzo Ronca, Grace E. Wootton, Natalia M. Krajewska, Amber G. Bozward, Rémi Fiancette, Daniel A. Patten, Katharina Yankouskaya, Gary M. Reynolds, Sofia Pat, Daniel C. Osei-Bordom, Naomi Richardson, Liam M. Grover, Christopher J. Weston, Ye H. Oo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we characterise the mechanism of CD8+ T cell invasion into BEC.
Externí odkaz:
https://doaj.org/article/8c5d5d80fa404d79a9d64d2f03722925
Autor:
Kathryn Olsen, James Hodson, Vincenzo Ronca, Amber G. Bozward, Jennifer Hayden, Grace Wootton, Matthew Armstrong, David H. Adams, Omar El‐Sherif, James Ferguson, Ellen Knox, Tracey Johnston, Fiona Thompson, Ye Htun Oo
Publikováno v:
Hepatology Communications, Vol 5, Iss 7, Pp 1252-1264 (2021)
Autoimmune hepatitis (AIH) is an immune‐mediated chronic liver disease that affects all ages, including women of childbearing age. Optimal management during pregnancy is poorly defined. We aimed to explore the clinical and biochemical course of AIH
Externí odkaz:
https://doaj.org/article/f08765a8d480426d83d9baa2dbcebdaa
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The tight relationship between the gut and liver on embryological, anatomical and physiological levels inspired the concept of a gut-liver axis as a central element in the pathogenesis of gut-liver axis diseases. This axis refers to the reciprocal re
Externí odkaz:
https://doaj.org/article/308e869485444b0e8d7cee92d71589d3
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite major advances in immunotherapy, hepatocellular carcinoma (HCC) remains a challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune response, which can be manipulated for immunotherapeutic benefit as primary
Externí odkaz:
https://doaj.org/article/b6f55cb9f7fb4bdc8585c3c5a7d97de7
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The maternal immune system engages in a fine balancing act during pregnancy by simultaneously maintaining immune tolerance to the fetus and immune responses to protect against invading organisms. Pregnancy is an intricately orchestrated process where
Externí odkaz:
https://doaj.org/article/8ae54668141840a9b3b97103d0306495
Publikováno v:
Seminars in Immunopathology. 44:461-474
Autoimmune liver diseases (AILD) include autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). These immune-mediated liver diseases involve a break down in peripheral self-tolerance with largely unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f5fc64436d7e72fdb8d1d84a35161d5
https://doi.org/10.1007/s00281-022-00940-w
https://doi.org/10.1007/s00281-022-00940-w
Autor:
Fiona Thompson, Vincenzo Ronca, Matthew J. Armstrong, Tracey Johnston, Omar El‐Sherif, Jennifer Hayden, Grace Wootton, Ye Htun Oo, Kathryn Olsen, James Hodson, Ellen Knox, David H. Adams, James Ferguson, Amber G. Bozward
Publikováno v:
Hepatology Communications, Vol 5, Iss 7, Pp 1252-1264 (2021)
Hepatology Communications
Hepatology Communications
Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease that affects all ages, including women of childbearing age. Optimal management during pregnancy is poorly defined. We aimed to explore the clinical and biochemical course of AIH i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6963367ab4c23cce1545ad6541f6f1cc
https://doaj.org/article/f08765a8d480426d83d9baa2dbcebdaa
https://doaj.org/article/f08765a8d480426d83d9baa2dbcebdaa
Publikováno v:
Best practiceresearch. Clinical gastroenterology.
Human liver possesses a persistent and tightly regulated immune response. Maintaining this homeostatic state is the key to prevent pathological processes, as a failure in clearing dangerous stimuli, is associated with tissue damage. A dysregulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ada121a40e22d617f98c56e0164ce93
https://pubmed.ncbi.nlm.nih.gov/34874849
https://pubmed.ncbi.nlm.nih.gov/34874849
Publikováno v:
Minerva gastroenterology.
The liver is a complex immunological organ. It has both immunogenic and tolerogenic capacity. Tolerogenic potential of human liver with its protective firewalls is required to guard the body against the continuous influx of microbial product from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2fb96644483cb9e5440890ad82247c
https://pubmed.ncbi.nlm.nih.gov/33793157
https://pubmed.ncbi.nlm.nih.gov/33793157
Publikováno v:
Cellular Immunology. 357:104195
The human liver is regarded as a lymphoid organ that contributes to both local and systemic immune response. Intrahepatic immune cells including regulatory T cells (Tregs) reside in the hepatic microenvironment which is enriched with proinflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21aef270c105931527557ce20f301c8b
https://doi.org/10.1016/j.cellimm.2020.104195
https://doi.org/10.1016/j.cellimm.2020.104195