Pulmonary Toxicities Associated With the Use of Immune Checkpoint Inhibitors: An Update From the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer

Autor: Bernardo L. Rapoport, Vickie R. Shannon, Tim Cooksley, Douglas B. Johnson, Lindsay Anderson, Ada G. Blidner, Gregory R. Tintinger, Ronald Anderson

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, with agents such as nivolumab, pembrolizumab, and cemiplimab targeting programmed cell death protein-1 (PD-1) and durvalumab, avelumab, and atezolizumab targe

Externí odkaz: https://doaj.org/article/407b43c0a26f43a19b522c1f1855c2df

Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8+ T Cell Function in Melanoma

Autor: Yamila I. Rodriguez, Ludmila E. Campos, Melina G. Castro, Nadia Bannoud, Ada G. Blidner, Verónica P. Filippa, Diego O. Croci, Gabriel A. Rabinovich, Sergio E. Alvarez

Publikováno v: Cells, Vol 9, Iss 11, p 2469 (2020)

The role of tumor necrosis factor-α (TNF-α) in shaping the tumor microenvironment is ambiguous. Consistent with its uncertain role in melanoma, TNF-α plays a dual role, either acting as a cytotoxic cytokine or favoring a tumorigenic inflammatory m

Externí odkaz: https://doaj.org/article/0624a3162ac64691a87d4bdecedb176a

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of severe gastrointestinal and hepatic toxicities from checkpoint inhibitors

Autor: Michael Dougan, Jennifer N. Choi, Ronald Anderson, Maria E. Suarez-Almazor, Douglas B. Johnson, Tim Cooksley, Ada G. Blidner, Vickie R. Shannon, Ilya G. Glezerman, Bernardo Leon Rapoport, Monica Girotra, Pamela K. Ginex, Dipti Gupta

Publikováno v: Support Care Cancer

Immune-related adverse events (IrAEs) affecting the gastrointestinal (GI) tract and liver are among the most frequent and most severe inflammatory toxicities from contemporary immunotherapy. Inflammation of the colon and or small intestines (entero)c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9850a49fbe97618d9d0e96e32444070c
https://doi.org/10.1007/s00520-020-05707-3

Defining events: 2020 in hindsight

Autor: Suchitra D. Gopinath, John Protzko, Samuel Nathan Kirshner, Ada G. Blidner, Elvira Sojli, Matúš Soták, Daniel A. Friedman, Bhavya Perma, Andreas Kupz, Roland Ruscher, Michael Tran Duong, Morgan Daly Dedyo, Michael A. Tarselli, Juliet Tegan Johnston, Mark Martin Jensen, Michael J. Strong, Anant Kumar Srivastava, Nikos Konstantinides, Felicia Beardsley, Athanasia Nikolaou, Katie Burnette, Isaac Z. Tanner, Divyansh Agarwal, JiaJia Fu, Basant A. Ali, Julia Yuen, Benedito Alves de Oliveira

Publikováno v: Science. 371:22-24

With 2020 finally behind us, we can begin to think about how the historic events that took place will be understood in years to come. To do so, we asked young scientists this question: What new word or phrase would you add to the dictionary to help s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450214618be7d40f594eb2255d80d3d7
https://doi.org/10.1126/science.abg0904

Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8⁺ regulatory T cells

Autor: Ada G. Blidner, Rosa M. Morales, Sabrina G. Gatto, Anabela M. Cutine, Martín Carlos Abba, Karina Mariño, Gabriel A. Rabinovich, Alejandro J. Cagnoni, María Laura Giribaldi, Diego O. Croci, Mariana Salatino

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Colorectal cancer (CRC) represents the third most common malignancy and the second leading cause of cancer-related deaths worldwide. Although immunotherapy has taken center stage in mainstream oncology, it has shown limited clinical efficacy in CRC,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf81a4ced10af6c8088f0d4a539ec1d4
http://sedici.unlp.edu.ar/handle/10915/146467