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Akademický článek

Minocycline Combined with Vancomycin for the Treatment of Methicillin-Resistant Coagulase-Negative Staphylococcal Prosthetic Joint Infection Managed with Exchange Arthroplasty

Autor: G. Bart, V. Zeller, Y. Kerroumi, B. Heym, V. Meyssonnier, N. Desplaces, M. D. Kitzis, J. M. Ziza, S. Marmor

Publikováno v: Journal of Bone and Joint Infection, Vol 5, Pp 110-117 (2020)

Introduction: Treatment of methicillin-resistant (MR) staphylococcal prosthetic joint infections (PJIs) remains a matter of discussion, with vancomycin-rifampin combination therapy being the preferred treatment for DAIR and one-stage exchange arthrop

Externí odkaz: https://doaj.org/article/1ef54d762aec4bbdaa9108a127dd73c1

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Akademický článek

Simultaneous double ionization of C60 molecules in single-cycle pulses

Autor: I Schubert, G Bart, T Brabec

Publikováno v: New Journal of Physics, Vol 23, Iss 2, p 023006 (2021)

We theoretically investigate simultaneous double ionization of C _60 Buckminsterfullerene clusters within the strong field approximation, taking into account two-body effects like Coulomb blocking. Our analysis suggests that for infrared single-cycle

Externí odkaz: https://doaj.org/article/99ff32c13cf248ba853857ea4884aa52

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Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1

Autor: Qian Wu, Gary L. Grunewald, Michael J. McLeish, Jian Lu, Kevin R. Criscione, Emily E. Scott, Aaron G. Bart

Publikováno v: Journal of Medicinal Chemistry. 63:13878-13898

The enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephrine and is a potential drug target, primarily for the control of hypertension. Unfortunately, many potent PNMT inhibitors al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f81629ebc9f59e2bc015723a28fdcaa
https://doi.org/10.1021/acs.jmedchem.0c01475

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Tuberculosis vertebral del adulto

Autor: G. Coiffier, G. Bart

Publikováno v: EMC - Aparato Locomotor. 53:1-18

Resumen La tuberculosis raquidea es una afeccion extrapulmonar clasica, que representa el 10-15% de las formas extrapulmonares de infeccion por Mycobacterium tuberculosis complex. Su distribucion es la de la tuberculosis pulmonar, especialmente frecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79cbacdabae6d3b90c91249e3047f99c
https://doi.org/10.1016/s1286-935x(20)44110-3

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Advances in the study of drug metabolism – symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX)

Autor: Chukwunonso K Nwabufo, Iain Martin, Matthew Segall, Fabio Broccatelli, Emily E. Scott, Eric Gonzalez, Jasleen K. Sodhi, Laura E Russell, Aaron G. Bart, Mary A. Schleiff, W. Griffith Humphreys, Ryan H. Takahashi, Mitchell E. Taub, Volker M. Lauschke, Bhagwat Prasad, Jessica H. Hartman

Publikováno v: Drug Metab Rev

The 12(th) International Society for the Study of Xenobiotics (ISSX) meeting, held in Portland, OR, USA from July 28–31, 2019, was attended by diverse members of the pharmaceutical sciences community. The ISSX New Investigators Group provides learn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844f39a310f1bc5b3ea0b9f878d9d00a
https://doi.org/10.1080/03602532.2020.1765793

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Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site

Autor: Elyse M. Petrunak, Aaron G. Bart, Hwei-Ming Peng, Richard J. Auchus, Emily E. Scott

Publikováno v: Journal of Biological Chemistry. 299:102999

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a742e7c82c8b7ecb48bcb04d0d5124
https://doi.org/10.1016/j.jbc.2023.102999

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L’arthrite septique inter-apophysaire : ses caractéristiques cliniques et microbiologiques. Une étude rétrospective multicentrique dans le Grand-Ouest

Autor: R. Tuil, P. Guggenbuhl, H. Emmanuel, B. Le Goff, D. Mulleman, S. Cadiou, C. Chollet, G. Bart, R. Lecomte, A. Lemagnen, C. Arvieux, H. Cormier

Publikováno v: Revue du Rhumatisme. 89:A48

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16eb7d4446997f7109e8db8e57a0634a
https://doi.org/10.1016/j.rhum.2022.10.058

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Effects of fluorine substitution on substrate conversion by cytochromes P450 17A1 and 21A2

Autor: Caleb D. Vogt, Emily E. Scott, Aaron G. Bart, Jeffrey Aubé, Rahul Yadav

Publikováno v: Org Biomol Chem

Cytochromes P450 17A1 (CYP7A1) and 21A2 (CYP21A2) catalyze key reactions in the production of steroid hormones, including mineralocorticoids, glucocorticoids, and androgens. With the ultimate goal of designing probes that are selectively metabolized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679a71e8dc8d7fe4ea9a57710c975bd8
https://pubmed.ncbi.nlm.nih.gov/34524336

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Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

Autor: Goreti Ribeiro Morais, Emily E. Scott, Aaron G. Bart, Klaus Pors, Venu R. Vangala, Paul M. Loadman

Publikováno v: Drug Metab Dispos

Duocarmycin natural products are promising anticancer cytotoxins but too potent for systemic use. Re-engineering of the duocarmycin scaffold has enabled the discovery of prodrugs designed for bioactivation by tissue-specific cytochrome P450 (P450) en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24238a9b3a3b66b808ce5c0a94c31947
https://pubmed.ncbi.nlm.nih.gov/34607808

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