Zobrazeno 1 - 10
of 351
pro vyhledávání: '"A. Francis Stewart"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-4 (2023)
Recent structures of DNA-bound bacterial and phage recombinases provide insights into homologous recombination and suggest relation to the eukaryotic Rad52 and identification of a Rad52 single strand annealing protein (SSAP) superfamily.
Externí odkaz:
https://doaj.org/article/87df98d886db484a95c25a6409de8c07
Autor:
Johanna Grinat, Julian Heuberger, Ramon Oliveira Vidal, Neha Goveas, Frauke Kosel, Antoni Berenguer-Llergo, Andrea Kranz, Annika Wulf-Goldenberg, Diana Behrens, Bálint Melcher, Sascha Sauer, Michael Vieth, Eduard Batlle, A. Francis Stewart, Walter Birchmeier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.
Externí odkaz:
https://doaj.org/article/3b5f2ff3d1124d7c81f483c2f20a5a38
Autor:
Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4
Externí odkaz:
https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
Autor:
Jia Yin, Wentao Zheng, Yunsheng Gao, Chanjuan Jiang, Hongbo Shi, Xiaotong Diao, Shanshan Li, Hanna Chen, Hailong Wang, Ruijuan Li, Aiying Li, Liqiu Xia, Yulong Yin, A. Francis Stewart, Youming Zhang, Jun Fu
Publikováno v:
iScience, Vol 14, Iss , Pp 1-14 (2019)
Summary: The limited efficiency of the available tools for genetic manipulation of Pseudomonas limits fundamental research and utilization of this genus. We explored the properties of a lambda Red-like operon (BAS) from Pseudomonas aeruginosa phage A
Externí odkaz:
https://doaj.org/article/4db6bdfd7bf64709a017e0b414576b4a
Autor:
Debojyoti Chakraborty, Maciej Paszkowski-Rogacz, Nicolas Berger, Li Ding, Jovan Mircetic, Jun Fu, Vytautas Iesmantavicius, Chunaram Choudhary, Konstantinos Anastassiadis, A. Francis Stewart, Frank Buchholz
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3012-3021 (2017)
Long noncoding RNAs (lncRNAs) have been implicated in diverse biological processes, including embryonic stem cell (ESC) maintenance. However, their functional mechanisms remain largely undefined. Here, we show that the lncRNA Panct1 regulates the tra
Externí odkaz:
https://doaj.org/article/26d7fd4feca44e1e81e064abd4826fe8
Autor:
Cemil Kerimoglu, M. Sadman Sakib, Gaurav Jain, Eva Benito, Susanne Burkhardt, Vincenzo Capece, Lalit Kaurani, Rashi Halder, Roberto Carlos Agís-Balboa, Roman Stilling, Hendrik Urbanke, Andrea Kranz, A. Francis Stewart, Andre Fischer
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 538-548 (2017)
Kmt2a and Kmt2b are H3K4 methyltransferases of the Set1/Trithorax class. We have recently shown the importance of Kmt2b for learning and memory. Here, we report that Kmt2a is also important in memory formation. We compare the decrease in H3K4 methyla
Externí odkaz:
https://doaj.org/article/7871a229fd1e453ba74299b288a33e19
Autor:
Wenli Zhang, Jun Fu, Jing Liu, Hailong Wang, Maren Schiwon, Sebastian Janz, Lukas Schaffarczyk, Lukas von der Goltz, Eric Ehrke-Schulz, Johannes Dörner, Manish Solanki, Philip Boehme, Thorsten Bergmann, Andre Lieber, Chris Lauber, Andreas Dahl, Andreas Petzold, Youming Zhang, A. Francis Stewart, Anja Ehrhardt
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1698-1709 (2017)
Adenoviruses (Ads) are large human-pathogenic double-stranded DNA (dsDNA) viruses presenting an enormous natural diversity associated with a broad variety of diseases. However, only a small fraction of adenoviruses has been explored in basic virology
Externí odkaz:
https://doaj.org/article/05491b28e9a94eaaac46bab0120beb0a
Autor:
Saminathan Ramakrishnan, Sivaraman Subramaniam, Charlotte Kielar, Guido Grundmeier, A. Francis Stewart, Adrian Keller
Publikováno v:
Molecules, Vol 25, Iss 21, p 5099 (2020)
Immobile Holliday junctions represent not only the most fundamental building block of structural DNA nanotechnology but are also of tremendous importance for the in vitro investigation of genetic recombination and epigenetics. Here, we present a deta
Externí odkaz:
https://doaj.org/article/acd880ced4c345898ff2f9f34e703dfa
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 3, Pp 305-310 (2011)
The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain desired gene mutations by using the following pro
Externí odkaz:
https://doaj.org/article/fa0453e87a9441ba97b1f4a3e8b43a94
Publikováno v:
HTS Teologiese Studies/Theological Studies, Vol 80, Iss 1, Pp e1-e9 (2024)
Rooted in the field of cathedral studies, this paper draws into dialogue three bodies of knowledge: Edward Bailey’s notion of implicit religion that, among other things, highlights the continuing traction of the Christian tradition and Christian pr
Externí odkaz:
https://doaj.org/article/9fa6c4a5d32f4a49a4ba1423384cc19a