Zobrazeno 1 - 10
of 4 624
pro vyhledávání: '"A. Filer"'
Autor:
M. Cole, C. Yap, C. Buckley, W. F. Ng, I. McInnes, A. Filer, S. Siebert, A. Pratt, J. D. Isaacs, D. D. Stocken
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a multi-c
Externí odkaz:
https://doaj.org/article/e288990549964c93a1c4b9c09a373ddf
Autor:
Richard D. Bell, Matthew Brendel, Maxwell A. Konnaris, Justin Xiang, Miguel Otero, Mark A. Fontana, Zilong Bai, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Daria M. Krenitsky, Nida Meednu, Javier Rangel-Moreno, Dagmar Scheel-Toellner, Hayley Carr, Saba Nayar, Jack McMurray, Edward DiCarlo, Jennifer H. Anolik, Laura T. Donlin, Dana E. Orange, H. Mark Kenney, Edward M. Schwarz, Andrew Filer, Lionel B. Ivashkiv, Fei Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disorder in which patients suffer from inflammatory-erosive arthritis. Recent advances on histopathology heterogeneity of RA synovial tissue revealed three distinct phenotyp
Externí odkaz:
https://doaj.org/article/b17d2655ca764faea6b9cae2cefd3a7a
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Autor:
Maximillian A. Robinson, Alan Kennedy, Carolina T. Orozco, Hung-Chang Chen, Erin Waters, Dalisay Giovacchini, Kay Yeung, Lily Filer, Claudia Hinze, Christopher Lloyd, Simon J. Dovedi, David M. Sansom
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114768- (2024)
Summary: The CTLA-4 and PD-1 checkpoints control immune responses and are key targets in immunotherapy. Both pathways are connected via a cis interaction between CD80 and PD-L1, the ligands for CTLA-4 and PD-1, respectively. This cis interaction prev
Externí odkaz:
https://doaj.org/article/bd659b5fd6cd460e8b103ac0c7d928f7
Autor:
Barbara Torlinska, Karim Raza, Andrew Filer, Gurpreet Jutley, Ilfita Sahbudin, Ruchir Singh, Paola de Pablo, Elizabeth Rankin, Benjamin Rhodes, Nicole Amft, Elizabeth Justice, Catherine McGrath, Sangeetha Baskar, Jeanette Trickey, Melanie Calvert, Marie Falahee
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Rheumatoid arthritis (RA) is often preceded by symptomatic phases during which classification criteria are not fulfilled. The health burden of these “at-risk” stages is not well described. This study assessed health-related qu
Externí odkaz:
https://doaj.org/article/e56bbe85a2454988952b0da856399b95
Autor:
Robinson, Maximillian A., Kennedy, Alan, Orozco, Carolina T., Chen, Hung-Chang, Waters, Erin, Giovacchini, Dalisay, Yeung, Kay, Filer, Lily, Hinze, Claudia, Lloyd, Christopher, Dovedi, Simon J., Sansom, David M.
Publikováno v:
In Cell Reports 24 September 2024 43(9)
Autor:
Martin, C.S, Crastin, A., Sagmeister, M.S., Kalirai, M.S., Turner, J.D., MacDonald, L., Kurowska-Stolarska, M., Scheel-Toellner, D., Taylor, A.E., Gilligan, L.C., Storbeck, K., Price, M., Gorvin, C.M., A, Filer, Mahida, R., Clark, A.R., Jones, S.W., Raza, K., Hewison, M., Hardy, R.S.
Publikováno v:
In Journal of Autoimmunity July 2024 147
Autor:
Norton, Sam, Lempp, Heidi, Opena, Maria, Subesinghe, Sujith, Garrood, Toby, Menon, Bina, Ng, Nora, Douglas, Karen, Koutsianas, Christos, Cooles, Faye, Falahee, Marie, Echavez-Naguicnic, Irene, Bharadwaj, Anurag, Villaruel, Michael, Pande, Ira, Collins, David, Pegler, Suzannah, Raizada, Sabrina, Siebert, Stefan, Fragoulis, George, Guinto, Jesusa, Galloway, James, Rutherford, Andrew, Barnes, Theresa, Jeffrey, Helen, Patel, Yusuf, Batley, Michael, O'Reilly, Brendan, Venkatachalam, Srivinisan, Sheeran, Thomas, Gorman, Claire, Reynolds, Piero, Khan, Asad, Gullick, Nicola, Banerjee, Siwalik, Mankia, Kulveer, Jordan, Deepak, Rowlands, Jane, Starmans-Kool, Mirian, Taylor, James, Nandi, Pradip, Sahbudin, Ilfita, Maybury, Mark, Hider, Samantha, Barcroft, Ann, McNally, Jeremy, Kitchen, Jo, Nisar, Muhammad, Quick, Vanessa, Cope, Andrew P *, Jasenecova, Marianna, Vasconcelos, Joana C, Filer, Andrew, Raza, Karim, Qureshi, Sumera, D'Agostino, Maria Antonietta, McInnes, Iain B, Isaacs, John D, Pratt, Arthur G, Fisher, Benjamin A, Buckley, Christopher D, Emery, Paul, Ho, Pauline, Buch, Maya H, Ciurtin, Coziana, van Schaardenburg, Dirkjan, Huizinga, Thomas, Toes, René, Georgiou, Evangelos, Kelly, Joanna, Murphy, Caroline, Prevost, A Toby
Publikováno v:
In The Lancet 2-8 March 2024 403(10429):838-849
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