Výsledky vyhledávání - "A. F. Steinert"

Akademický článek

Reduced hypertrophy in vitro after chondrogenic differentiation of adult human mesenchymal stem cells following adenoviral SOX9 gene delivery

Autor: M. Weissenberger, M. H. Weissenberger, F. Gilbert, J. Groll, C. H. Evans, A. F. Steinert

Publikováno v: BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-14 (2020)

Abstract Background Mesenchymal stem cell (MSC) based-treatments of cartilage injury are promising but impaired by high levels of hypertrophy after chondrogenic induction with several bone morphogenetic protein superfamily members (BMPs). As an alter

Externí odkaz: https://doaj.org/article/5e5df6b27e7c459ea218bf0edd09bc5e

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Akademický článek

Comparative in vitro treatment of mesenchymal stromal cells with GDF‐5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy

Autor: Manuel Weißenberger, Mike Wagenbrenner, Joachim Nickel, Rasmus Ahlbrecht, Torsten Blunk, Andre F. Steinert, Fabian Gilbert

Publikováno v: Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)

Abstract Purpose Hypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis. Although the exact pathomechanism remains poorly understood, hypertrophic de‐differentiation

Externí odkaz: https://doaj.org/article/4d5cf41e237a4938861d1e9315d552a4

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Akademický článek

The human arthritic hip joint is a source of mesenchymal stromal cells (MSCs) with extensive multipotent differentiation potential

Autor: Mike Wagenbrenner, Tizian Heinz, Konstantin Horas, Axel Jakuscheit, Joerg Arnholdt, Marietta Herrmann, Maximilian Rudert, Boris M. Holzapfel, Andre F. Steinert, Manuel Weißenberger

Publikováno v: BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-13 (2020)

Abstract Background While multiple in vitro studies examined mesenchymal stromal cells (MSCs) derived from bone marrow or hyaline cartilage, there is little to no data about the presence of MSCs in the joint capsule or the ligamentum capitis femoris

Externí odkaz: https://doaj.org/article/5156c3d3f4c04ccca3517da8e5bb6451

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Akademický článek

PMMA Bone Cement: Antibiotic Elution and Mechanical Properties in the Context of Clinical Use

Autor: Sebastian Philipp von Hertzberg-Boelch, Martin Luedemann, Maximilian Rudert, Andre F. Steinert

Publikováno v: Biomedicines, Vol 10, Iss 8, p 1830 (2022)

This literature review discusses the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. The clinically relevant differences that have to be considered when antibiotic loaded bone cements (ALBC) are used either for long-term

Externí odkaz: https://doaj.org/article/3923e7ea118c4c418bada21f1b24b630

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Akademický článek

Different types of cartilage neotissue fabricated from collagen hydrogels and mesenchymal stromal cells via SOX9, TGFB1 or BMP2 gene transfer.

Autor: Manuel Weißenberger, Manuela H Weißenberger, Mike Wagenbrenner, Tizian Heinz, Jenny Reboredo, Boris M Holzapfel, Maximilian Rudert, Jürgen Groll, Christopher H Evans, Andre F Steinert

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237479 (2020)

OBJECTIVE:As native cartilage consists of different phenotypical zones, this study aims to fabricate different types of neocartilage constructs from collagen hydrogels and human mesenchymal stromal cells (MSCs) genetically modified to express differe

Externí odkaz: https://doaj.org/article/da3f9100c56d426ab77185b3ea51799c

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Patient-specific cruciate-retaining total knee replacement with individualized implants and instruments (iTotal™ CR G2)

Autor: Maximilian Rudert, Boris Michael Holzapfel, Andre F. Steinert, Jörg Arnholdt, L. Sefrin, Lennart Schröder, Björn Jansen

Publikováno v: Operative Orthopädie und Traumatologie. 33:170-180

Treatment of tricompartimental osteoarthritis (OA) using customized instruments and implants for cruciate-retaining total knee arthroplasty. Use of patient-specific instruments and implants (ConforMIS iTotalSymptomatic tricompartmental OA of the knee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fc5968407d3597ed533ff5f84d9893
https://doi.org/10.1007/s00064-020-00690-8

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The Impact of Total Knee Replacement with a Customized Cruciate-Retaining Implant Design on Patient-Reported and Functional Outcomes

Autor: Andre F. Steinert, Lennart Schröder, Lukas Sefrin, Björn Janßen, Jörg Arnholdt, Maximilian Rudert

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 2; Pages: 194

Purpose: To treat patients with tricompartimental knee osteoarthritis (OA), a customized cruciate-retaining total knee arthroplasty (CCR-TKA) system can be used, including both individualized instrumentation and implants. The objective of this monoce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e14ee045daf7b76abcbf5d2ae4c62d

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Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines

Autor: Christian Konrads, Franz Jakob, Matthias Schieker, Denitsa Docheva, Andre F. Steinert, Patrick Prager

Publikováno v: Biomedical Journal
Biomedical Journal, Vol 42, Iss 6, Pp 371-380 (2019)

Background: The anterior-cruciate-ligament (ACL) contains mesenchymal stem cells (ACL-MSCs), suggesting the feasibility of regenerative treatments of this tissue. The immortalization of isolated cells results in cell-lines applicable to develop cell-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65863c11696fb8fc6f5f59e234d4f6e4
http://europepmc.org/articles/PMC6962762

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