Zobrazeno 1 - 10
of 161
pro vyhledávání: '"A. F. Palazzo"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 145-156 (2024)
The division of the cellular space into nucleoplasm and cytoplasm promotes quality control mechanisms that prevent misprocessed mRNAs and junk RNAs from gaining access to the translational machinery. Here, we explore how properly processed mRNAs are
Externí odkaz:
https://doaj.org/article/88865b87ba4d4966afe967aed15056fe
Autor:
Yi Qiu, Yoon Mo Kang, Christopher Korfmann, Fanny Pouyet, Andrew Eckford, Alexander F. Palazzo
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background In vertebrates, most protein-coding genes have a peak of GC-content near their 5′ transcriptional start site (TSS). This feature promotes both the efficient nuclear export and translation of mRNAs. Despite the importance of GC-c
Externí odkaz:
https://doaj.org/article/4d6e819d1914485eb98112d2551117af
Autor:
V. Talya Yerlici, Audrey Astori, Nevraj S. Kejiou, Chris A. Jordan, Negin Khosraviani, Janet N.Y. Chan, Razqallah Hakem, Brian Raught, Alexander F. Palazzo, Karim Mekhail
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113891- (2024)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinders host gene expression, curbing defenses and licensing viral protein synthesis and virulence. During SARS-CoV-2 infection, the virulence factor non-structural protein 1 (Nsp1
Externí odkaz:
https://doaj.org/article/9e4365a8fcd54a9cb81200c0431b45c3
Autor:
Benoît Gouy, Adrien Decorsière, Sophie Desgraupes, Wenming Duan, Hong Ouyang, Yifan E. Wang, E. Ann Yeh, Alexander F. Palazzo, Theo J. Moraes, Sébastien Nisole, Nathalie J. Arhel
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Acute necrotizing encephalopathy 1 (ANE1) is a very rare disorder associated with a dominant heterozygous mutation in the RANBP2 (RAN binding protein 2) gene. ANE1 is frequently triggered by a febrile infection and characterized by serious and irreve
Externí odkaz:
https://doaj.org/article/89f0d98b71104f8e9ff390c2e0630eff
Publikováno v:
Nucleus, Vol 13, Iss 1, Pp 154-169 (2022)
Dominant missense mutations in RanBP2/Nup358 cause Acute Necrotizing Encephalopathy (ANE), a pediatric disease where seemingly healthy individuals develop a cytokine storm that is restricted to the central nervous system in response to viral infectio
Externí odkaz:
https://doaj.org/article/1c000b1d2bc4405ebf7a990e65168888
Autor:
M. Iannaccone, R. Elgendy, A. Ianni, C. Martino, F. Palazzo, M. Giantin, L. Grotta, M. Dacasto, G. Martino
Publikováno v:
Animal, Vol 14, Iss 4, Pp 745-752 (2020)
Iodine (I) is a micronutrient that mammals need for proper functionality of thyroid gland since it is the main component of thyroid hormones. Besides studies that have investigated the role of I in livestock nutrition, it is also important to know th
Externí odkaz:
https://doaj.org/article/7b393e3027ba4e19a091ea299ac0a208
Autor:
Alexander F. Palazzo, Nevraj S. Kejiou
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
With the discovery of the double helical structure of DNA, a shift occurred in how biologists investigated questions surrounding cellular processes, such as protein synthesis. Instead of viewing biological activity through the lens of chemical reacti
Externí odkaz:
https://doaj.org/article/8e21a777f9eb499ab7eeaebdfb38bc03
Autor:
K. E. Isaacs, S. Belete, B. J. Miller, A. N. Di Marco, S. Kirby, T. Barwick, N. S. Tolley, J. R. Anderson, F. F. Palazzo
Publikováno v:
BJS Open, Vol 3, Iss 6, Pp 743-749 (2019)
Background Primary hyperparathyroidism (PHPT), caused by an ectopic mediastinal parathyroid adenoma, is uncommon. In the past, when the adenoma was not accessible from the neck, median sternotomy was advocated for safe and successful parathyroidectom
Externí odkaz:
https://doaj.org/article/2115c421b8974217938807e42dcb7257
Autor:
Shamaila Zaman, Raya Almazrouei, Amir H. Sam, Aimee N. DiMarco, Jeannie F. Todd, Fausto F. Palazzo, Tricia Tan, Waljit S. Dhillo, Karim Meeran, Florian Wernig
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundCortisol levels in response to stress are highly variable. Baseline and stimulated cortisol levels are commonly used to determine adrenal function following unilateral adrenalectomy. We report the results of synacthen stimulation testing fo
Externí odkaz:
https://doaj.org/article/0f58c973711e446997f340718b6e521e
Autor:
Qingtang Shen, Yifan E Wang, Mathew Truong, Kohila Mahadevan, Jingze J Wu, Hui Zhang, Jiawei Li, Harrison W Smith, Craig A Smibert, Alexander F Palazzo
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009378 (2021)
Mutations in RanBP2 (also known as Nup358), one of the main components of the cytoplasmic filaments of the nuclear pore complex, contribute to the overproduction of acute necrotizing encephalopathy (ANE1)-associated cytokines. Here we report that Ran
Externí odkaz:
https://doaj.org/article/b93f08f948f04a9fb584b70576baef0e