Výsledky vyhledávání - "A. F. Ochsenbein"

Akademický článek

LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

Autor: S. S. Höpner, Ana Raykova, R. Radpour, M. A. Amrein, D. Koller, G. M. Baerlocher, C. Riether, A. F. Ochsenbein

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Regulation of self-renewal is critical during steady state and stress in haematpoietic stem cells (HSCs), and underlies leukaemia pathology. Here, the authors show that LIGHT and its receptor LTβR promote quiescence and self-renewal of HSCs and that

Externí odkaz: https://doaj.org/article/8bf20fdc21164bb0a145089a5033e21d

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Akademický článek

Tumour mutations in long noncoding RNAs enhance cell fitness

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Long noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell fitness via function-altering somatic “driver” mutations. To search

Externí odkaz: https://doaj.org/article/ac68b1f51d77424ab680971f8fdf0575

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Akademický článek

Molecular and immunological mechanisms of clonal evolution in multiple myeloma

Autor: Stefan Forster, Ramin Radpour, Adrian F. Ochsenbein

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of clonal plasma cells in the bone marrow (BM). It is known that early genetic mutations in post-germinal center B/plasma cells are the cause of myelomagenesis. The

Externí odkaz: https://doaj.org/article/0a95875e38f343f3931a95198121c0f3

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Akademický článek

MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma

Autor: Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R. R. Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F. Ochsenbein, Thomas M. Marti, Gregor J. Kocher, Ralph A. Schmid, Patrick Dorn, Ren-Wang Peng

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)

Abstract Malignant pleural mesothelioma (MPM) is a lethal malignancy etiologically caused by asbestos exposure, for which there are few effective treatment options. Although asbestos carcinogenesis is associated with reactive oxygen species (ROS), th

Externí odkaz: https://doaj.org/article/5254c7ce468140869bc77e5e71f90aa3

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Akademický článek

Results from a phase I/II trial of cusatuzumab combined with azacitidine in patients with newly diagnosed acute myeloid leukemia who are ineligible for intensive chemotherapy

Publikováno v: Haematologica, Vol 108, Iss 7 (2023)

Cusatuzumab is a high-affinity, anti-CD70 monoclonal antibody under investigation in acute myeloid leukemia (AML). This two-part, open-label, multicenter, phase I/II trial evaluated cusatuzumab plus azacitidine in patients with newly diagnosed AML in

Externí odkaz: https://doaj.org/article/44a72b022e1b4366bad1fca7a93513e4

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Data from T-cell–Secreted TNFα Induces Emergency Myelopoiesis and Myeloid-Derived Suppressor Cell Differentiation in Cancer

Autor: Adrian F. Ochsenbein, Carsten Riether, Ramin Radpour, Anne-Laure Huguenin, Elias D. Bührer, Michael A. Amrein, Mohamad F. Al Sayed

Hematopoiesis in patients with cancer is characterized by reduced production of red blood cells and an increase in myelopoiesis, which contributes to the immunosuppressive environment in cancer. Some tumors produce growth factors that directly stimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f3bee810456bca8f6014ab1a36adff
https://doi.org/10.1158/0008-5472.c.6510785.v1

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Supplementary Data from T-cell–Secreted TNFα Induces Emergency Myelopoiesis and Myeloid-Derived Suppressor Cell Differentiation in Cancer

Autor: Adrian F. Ochsenbein, Carsten Riether, Ramin Radpour, Anne-Laure Huguenin, Elias D. Bührer, Michael A. Amrein, Mohamad F. Al Sayed

Table S1: suppl. cell cycle analysis to Fig 3; Table S2: suppl. BrDU and AnnexinV analysis to Fig 3; Table S3: suppl. analysis of the compositions of HSPC compartments to Fig 4; Figure S1: suppl. to Fig 1; Figure S2: suppl. to Fig 4; Figure S3: suppl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7986e1bd4d17aaee92211fc8dde92ee9
https://doi.org/10.1158/0008-5472.22420922.v1

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Data from Decreased Tumor Surveillance after Adoptive T-Cell Therapy

Autor: Adrian F. Ochsenbein, Dorothee von Laer, Tsanan Giroglou, Bruno Eschli, Sabine Mumprecht, Daniel D. Pinschewer, Viktor Pavelic, Matthias Matter

The effect of cancer immunotherapy on the endogenous immune response against tumors is largely unknown. Therefore, we studied immune responses against murine tumors expressing the glycoprotein (GP) and/or nucleoprotein of lymphocytic choriomeningitis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d59691124c9ed8697ae6aca516bf77d
https://doi.org/10.1158/0008-5472.c.6495833

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