Výsledky vyhledávání - "A. F. M. Verheul"

Transferrin toxin but not transferrin receptor immunotoxin is influenced by free transferrin and iron saturation

Autor: W C Vooijs, P H Gosselaar, Letizia Polito, A F M Verheul, Joannes J.M. Marx, A J G van-Dijk, H G J Krouwer, G C de-Gast, Andrea Bolognesi

Publikováno v: European Journal of Clinical Investigation. 32:61-69

Background Cytotoxic agents can be targeted successfully to cancer cells. The efficacy of such novel and potent anticancer strategies may be influenced by variables of iron metabolism. Methods The in vitro cytotoxicity against glioma cells of transfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a06d64e3b74ff8f0ce197cd8a7150a1e
https://doi.org/10.1046/j.1365-2362.2002.0320s1061.x

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Are the Opsonophagocytic Activities of Antibodies in Infant Sera Measured by Different Pneumococcal Phagocytosis Assays Comparable?

Autor: Helena Käyhty, Wouter T. M. Jansen, Ingileif Jonsdottir, Harm Snippe, Merja Väkeväinen, Eirikur Saeland, André F. M. Verheul

Publikováno v: Clinical Diagnostic Laboratory Immunology. 8:363-369

Opsonophagocytosis mediated by antibodies and complement is the major mechanism for clearing Streptococcus pneumoniae (Pnc) from the host (19, 22). Therefore, the in vitro opsonophagocytic activity (OPA) of antibodies to pneumococcal capsular polysac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6ff2512b4fa18cc52a898ff19c7265
https://doi.org/10.1128/cdli.8.2.363-369.2001

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Synthetic 6B Di-, Tri-, and Tetrasaccharide-Protein Conjugates Contain Pneumococcal Type 6A and 6B Common and 6B- Specific Epitopes That Elicit Protective Antibodies in Mice

Autor: Harm Snippe, Johannis P. Kamerling, André F. M. Verheul, Mark J. L. Thijssen, Sietske Hogenboom, Johannes F.G. Vliegenthart, Wouter T. M. Jansen, Jan Verhoef

Publikováno v: Infection and Immunity. 69:787-793

The immunogenicity and protective capacity of Streptococcus pneumoniae 6B capsular polysaccharide (PS)-derived synthetic phosphate-containing disaccharide (Rha-ribitol- P -), trisaccharide (ribitol- P -Gal-Glc-), and tetrasaccharide (Rha-ribitol- P -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cda4d079e93d0817745b5306bd89900
https://doi.org/10.1128/iai.69.2.787-793.2001

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Evaluation of T-cell responses to peptides and lipopeptides with MHC class I binding motifs derived from the amino acid sequence of the 19-kDa lipoprotein of Mycobacterium tuberculosis

Autor: Harm Snippe, André F. M. Verheul, Dianne P. H. Joosten, Dora P. A. J. Fonseca

Publikováno v: Molecular Immunology. 37:413-422

Cytotoxic T-lymphocyte (CTL) epitopes on the 19-kDa lipoprotein from Mycobacterium tuberculosis were identified by the use of lipopeptides and their cytokine profile studied. Selection of candidate CTL epitopes was based on synthetic peptides derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef0d297dd986b5c2b77ccb9689e5710
https://doi.org/10.1016/s0161-5890(00)00066-3

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Pulmonary surfactant protein A binds toCryptococcus neoformanswithout promoting phagocytosis

Autor: J. Scharringa, I M Hoepelman, Annemiek M E Walenkamp, A. F. M. Verheul

Publikováno v: European Journal of Clinical Investigation. 29:83-92

Background Evidence is accumulating that the alveolar collectin surfactant protein A (SP-A) plays an important role in the first line of defence against infiltrating pathogenic micro-organisms and viruses. The ability of SP-A to facilitate the bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75eb28347506f30fb8aed264e27ca911
https://doi.org/10.1046/j.1365-2362.1999.00429.x

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Use of Highly Encapsulated Streptococcus pneumoniae Strains in a Flow-Cytometric Assay for Assessment of the Phagocytic Capacity of Serotype-Specific Antibodies

Autor: M. Zelle, Wouter T. M. Jansen, Jan Verhoef, Harm Snippe, Dace V. Madore, A. F. M. Verheul, J. Gootjes

Publikováno v: Clinical Diagnostic Laboratory Immunology. 5:703-710

A phagocytosis assay for Streptococcus pneumoniae based on flow cytometry (FACS) with human polymorphonuclear cells and human complement was developed for the study of human vaccination antisera. Human prevaccination sera already contain high levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ff6436792352f0059f0ba712fd75a1
https://doi.org/10.1128/cdli.5.5.703-710.1998

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A functional defect in hereditary haemochromatosis monocytes and monocyte‐derived macrophages

Autor: A. F. M. Verheul, Joannes J.M. Marx, E. Moura

Publikováno v: European Journal of Clinical Investigation. 28:164-173

Background Hereditary haemochromatosis (HH) is a disease of the metabolism of iron characterized by increased iron absorption and heavy parenchymal iron deposition, but with the presence of little iron in the mononuclear phagocytic system (MPS). Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10856b91b05766e25b6017d9fd214bd
https://doi.org/10.1046/j.1365-2362.1998.00263.x

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Influenza virus neutralizing antibodies and IgG isotype profiles after immunization of mice with influenza A subunit vaccine using various adjuvants

Autor: Martin C. Harmsen, Harm Snippe, W. van der Graaff, André F. M. Verheul, C. A. Kraaijeveld, C. A. Benne

Publikováno v: Vaccine. 15:1039-1044

The influence of various adjuvants on the development of influenza virus neutralizing antibodies and distribution of anti-influenza virus IgG isotypes after immunization of mice with influenza A (H3N2) subunit vaccine was investigated. Serum titres o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd79892a686a948e7ffbab7e55984b98
https://doi.org/10.1016/s0264-410x(96)00287-3

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Mannoproteins of Cryptococcus neoformans induce proliferative response in human peripheral blood mononuclear cells (PBMC) and enhance HIV-1 replication

Autor: Maarten R. Visser, Harm Snippe, N. M. de Vos, V. V. Vaishnav, Jan Verhoef, J. M. Orendi, A. F. M. Verheul, R. Cherniak, Ger T. Rijkers

Publikováno v: Clinical and Experimental Immunology. 107:293-299

SUMMARY To investigate the possible role of Cryptococcus neoformans var. neoformans in HIV disease progression, and to identify the responsible cryptococcal components, an in vitro cell culture model was set up to study the C. neoformans-induced enha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a5607aa7b1a800ddfce94c452f8441
https://doi.org/10.1111/j.1365-2249.1997.283-ce1169.x

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Cryptococcus neoformans and cryptococcal glucuronoxylomannan, galactoxylomannan, and mannoprotein induce different levels of tumor necrosis factor alpha in human peripheral blood mononuclear cells

Autor: Robert Cherniak, I M Hoepelman, André F. M. Verheul, V. V. Vaishnav, W Chaka, Jan Verhoef, Harm Snippe, Jelle Scharringa

Publikováno v: Infection and Immunity. 65:272-278

Tumor necrosis factor alpha (TNF-alpha) release by peripheral blood mononuclear cells (PBMC) during disseminated infection by Cryptococcus neoformans may initiate and amplify the immune response of the host, leading to elimination of the fungus. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cf2c06317427c63ad23e5684417613
https://doi.org/10.1128/iai.65.1.272-278.1997

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