Zobrazeno 1 - 10
of 1 070
pro vyhledávání: '"A. F. Gazdar"'
Autor:
Ling Cai, Hongyu Liu, Fang Huang, Junya Fujimoto, Luc Girard, Jun Chen, Yongwen Li, Yu-An Zhang, Dhruba Deb, Victor Stastny, Karine Pozo, Christin S. Kuo, Gaoxiang Jia, Chendong Yang, Wei Zou, Adeeb Alomar, Kenneth Huffman, Mahboubeh Papari-Zareei, Lin Yang, Benjamin Drapkin, Esra A. Akbay, David S. Shames, Ignacio I. Wistuba, Tao Wang, Jane E. Johnson, Guanghua Xiao, Ralph J. DeBerardinis, John D. Minna, Yang Xie, Adi F. Gazdar
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Ling Cai et al. used transcriptomic profiling data of healthy lung, patient-derived small cell lung cancer cell lines, xenografts, and primary tumors to examine a link between neuroendocrine (NE) signatures and immune gene expression. Their findings
Externí odkaz:
https://doaj.org/article/c88977f0af0c4f029def4e50d414f3bb
Autor:
Hans K. Ghayee, Yiling Xu, Heather Hatch, Richard Brockway, Asha S. Multani, Tongjun Gu, Wendy B. Bollag, Adina Turcu, William E. Rainey, Juilee Rege, Kazutaka Nanba, Vikash J. Bhagwandin, Fiemu Nwariaku, Victor Stastny, Adi F. Gazdar, Jerry W. Shay, Richard J. Auchus, Sergei G. Tevosian
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 584 (2022)
The human adrenal cortex is composed of distinct zones that are the main source of steroid hormone production. The mechanism of adrenocortical cell differentiation into several functionally organized populations with distinctive identities remains po
Externí odkaz:
https://doaj.org/article/6db15ebcdfba404f90c05358b2a3b4b8
Publikováno v:
BioData Mining, Vol 12, Iss 1, Pp 1-15 (2019)
Abstract Tremendous amount of whole-genome sequencing data have been provided by large consortium projects such as TCGA (The Cancer Genome Atlas), COSMIC and so on, which creates incredible opportunities for functional gene research and cancer associ
Externí odkaz:
https://doaj.org/article/ca7b07da861746889a5325a91280cee6
Autor:
Luka Brcic, Christian Kuchler, Sylvia Eidenhammer, Daniela Pabst, Franz Quehenberger, Adi F. Gazdar, Helmut Popper
Publikováno v:
Diagnostic Pathology, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background Small cell lung cancer (SCLC) is usually diagnosed in the advanced stage. It has a very poor prognosis, with no advancements in therapy in the last few decades. A recent phase 1 clinical study, using an antibody-drug conjugate dir
Externí odkaz:
https://doaj.org/article/9ee65802d0e544c5a1394a0ec0244c3a
Autor:
Min He, Shanshan Liu, Sachith Gallolu Kankanamalage, Mark D. Borromeo, Luc Girard, Adi F. Gazdar, John D. Minna, Jane E. Johnson, Melanie H. Cobb
Publikováno v:
Translational Oncology, Vol 11, Iss 2, Pp 292-299 (2018)
Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma, designated as a recalcitrant cancer by the National Cancer Institute, in urgent need of new rational therapeutic targets. Previous studies have determined that the basic helix-l
Externí odkaz:
https://doaj.org/article/1defee1706d14f1d999e8f2802d42433
Autor:
Maithili P. Dalvi, Lei Wang, Rui Zhong, Rahul K. Kollipara, Hyunsil Park, Juan Bayo, Paul Yenerall, Yunyun Zhou, Brenda C. Timmons, Jaime Rodriguez-Canales, Carmen Behrens, Barbara Mino, Pamela Villalobos, Edwin R. Parra, Milind Suraokar, Apar Pataer, Stephen G. Swisher, Neda Kalhor, Natarajan V. Bhanu, Benjamin A. Garcia, John V. Heymach, Kevin Coombes, Yang Xie, Luc Girard, Adi F. Gazdar, Ralf Kittler, Ignacio I. Wistuba, John D. Minna, Elisabeth D. Martinez
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1669-1684 (2017)
Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established preclinical taxane-platin-chemoresistance models and identified a 35-gene resistance signa
Externí odkaz:
https://doaj.org/article/b799525f4c5f4794b566dfe7987f5ae9
Autor:
Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar, Michael G. Roth
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Lung cancers often harbour loss-of-function mutations inSMARCA4. Here, the authors demonstrate a vulnerability of SMARCA4-deficient lung cancers for Aurora kinase A inhibition associated with mitotic defects.
Externí odkaz:
https://doaj.org/article/f81ec3448b26422b8d9847f84e7abb5c
Autor:
David MacPherson, Kwon-Sik Park, Hamid Bolouri, Adi F. Gazdar, Smitha P.S. Pillai, Colin T. Dunn, Kee-Beom Kim, Ali H. Ibrahim, Nan Wu, Emily Eastwood, Dong-Wook Kim, Arnaud Augert, Deshui Jia
Supplementary tables S1 to S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2980c42ecca9ece263595a071b8307c2
https://doi.org/10.1158/2159-8290.22531804
https://doi.org/10.1158/2159-8290.22531804
Autor:
John D. Minna, Masatomo Mori, Adi F. Gazdar, Yang Xie, Kyoichi Kaira, Noriko Yanagitani, Mitsuo Sato, Junichi Soh, Hisao Imai, Jill E. Larsen, Michael Peyton, Luc Girard, David S. Shames, Noriaki Sunaga
Supplementary Figures 1-4 from Knockdown of Oncogenic KRAS in Non–Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e69c11377d0574216a08211f6d710b
https://doi.org/10.1158/1535-7163.22496802
https://doi.org/10.1158/1535-7163.22496802
Autor:
John D. Minna, Jerry W. Shay, Adi F. Gazdar, Ignacio I. Wistuba, Yang Xie, Boning Gao, John Michael DiMaio, Hao Tang, Ruben D. Ramirez, Maithili P. Dalvi, David S. Shames, Han Sun, Woochang Lee, Jill E. Larsen, Mitsuo Sato
We used CDK4/hTERT–immortalized normal human bronchial epithelial cells (HBEC) from several individuals to study lung cancer pathogenesis by introducing combinations of common lung cancer oncogenic changes (p53, KRAS, and MYC) and followed the step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a5a2477fae9066c401d7fbdac5d0d3
https://doi.org/10.1158/1541-7786.c.6539553.v1
https://doi.org/10.1158/1541-7786.c.6539553.v1