Zobrazeno 1 - 10
of 513
pro vyhledávání: '"A. F. Fraga"'
Autor:
Raúl F. Pérez, Patricia Tezanos, Alfonso Peñarroya, Alejandro González-Ramón, Rocío G. Urdinguio, Javier Gancedo-Verdejo, Juan Ramón Tejedor, Pablo Santamarina-Ojeda, Juan José Alba-Linares, Lidia Sainz-Ledo, Annalisa Roberti, Virginia López, Cristina Mangas, María Moro, Elisa Cintado Reyes, Pablo Muela Martínez, Mar Rodríguez-Santamaría, Ignacio Ortea, Ramón Iglesias-Rey, Juan Castilla-Silgado, Cristina Tomás-Zapico, Eduardo Iglesias-Gutiérrez, Benjamín Fernández-García, Jose Vicente Sanchez-Mut, José Luis Trejo, Agustín F. Fernández, Mario F. Fraga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Aging involves the deterioration of organismal function, leading to the emergence of multiple pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this process and may be used as tools in the pursuit of he
Externí odkaz:
https://doaj.org/article/4c4a8c6ac5de4ae1a06f001803b72c14
Autor:
Alfonso Peñarroya, Rebeca Lorca, José Julián Rodríguez Reguero, Juan Gómez, Pablo Avanzas, Juan Ramon Tejedor, Agustín F. Fernandez, Mario F. Fraga
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Background Hypertrophic cardiomyopathy is an autosomal dominant cardiac disease. The mechanisms that determine its variable expressivity are poorly understood. Epigenetics could play a crucial role in bridging the gap between genotype and phenotype b
Externí odkaz:
https://doaj.org/article/46e63391c45c41ae8d0a7886775cb27e
Autor:
Neus Baena, David Monk, Cinthia Aguilera, Mario F. Fraga, Agustín F. Fernández, Elisabeth Gabau, Raquel Corripio, Nuria Capdevila, Juan Pablo Trujillo, Anna Ruiz, Miriam Guitart
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Temple syndrome (TS14) is a rare imprinting disorder caused by maternal UPD14, imprinting defects or paternal microdeletions which lead to an increase in the maternal expressed genes and a silencing the paternally expressed genes
Externí odkaz:
https://doaj.org/article/af22d34ee914432088d10b491ca50764
Autor:
Verónica Rey, Juan Tornín, Juan Jose Alba-Linares, Cristina Robledo, Dzohara Murillo, Aida Rodríguez, Borja Gallego, Carmen Huergo, Cristina Viera, Alejandro Braña, Aurora Astudillo, Dominique Heymann, Karoly Szuhai, Judith V.M.G. Bovée, Agustín F. Fernández, Mario F. Fraga, Javier Alonso, René Rodríguez
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105090- (2024)
Summary: Background: Sarcomas represent an extensive group of malignant diseases affecting mesodermal tissues. Among sarcomas, the clinical management of chondrosarcomas remains a complex challenge, as high-grade tumours do not respond to current the
Externí odkaz:
https://doaj.org/article/a9bcedfaab4940eeb62fdf6d5e65245e
Autor:
V. S. W. Orlando, G. D. Martins, E. F. Fraga Júnior, A. B. Marra, F. V. Pereira, M. d. L. B. T. Galo
Publikováno v:
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol X-1-W1-2023, Pp 91-96 (2023)
Leaf Water Potential (LWP) is an indicator widely used to understand water relations in a coffee tree. Monitoring water potential is a challenge for remote sensing using low-cost multispectral cameras, with images taken by remotely piloted aircraft.
Externí odkaz:
https://doaj.org/article/4876bbc68f5947d1b5847b244b0f4d22
Autor:
Pablo Santamarina‐Ojeda, Juan Ramón Tejedor, Raúl F. Pérez, Virginia López, Annalisa Roberti, Cristina Mangas, Agustín F. Fernández, Mario F. Fraga
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1726-1743 (2023)
Glioblastoma (GBM) is one of the most aggressive types of cancer and exhibits profound genetic and epigenetic heterogeneity, making the development of an effective treatment a major challenge. The recent incorporation of molecular features into the d
Externí odkaz:
https://doaj.org/article/cc6d93e16d2b4020b5171ebe1f8e0445
Autor:
Juan Ramón Tejedor, Alfonso Peñarroya, Javier Gancedo-Verdejo, Pablo Santamarina-Ojeda, Raúl F. Pérez, Sara López-Tamargo, Ana Díez-Borge, Juan J. Alba-Linares, Nerea González-del-Rey, Rocío G. Urdinguio, Cristina Mangas, Annalisa Roberti, Virginia López, Teresa Morales-Ruiz, Rafael R. Ariza, Teresa Roldán-Arjona, Mónica Meijón, Luis Valledor, María Jesús Cañal, Daniel Fernández-Martínez, María Fernández-Hevia, Paula Jiménez-Fonseca, Luis J. García-Flórez, Agustín F. Fernández, Mario F. Fraga
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation of colorectal cancer (CRC). However, whether this epigenetic mechanism is functional in cancer or is a mere consequenc
Externí odkaz:
https://doaj.org/article/95cb022c2afa458ba4a52e0c37ea095b
Autor:
Paula Morales-Sánchez, Carmen Lambert, Jessica Ares-Blanco, Lorena Suárez-Gutiérrez, Elsa Villa-Fernández, Ana Victoria Garcia, Miguel García-Villarino, Juan Ramón Tejedor, Mario F. Fraga, Edelmiro Menéndez Torre, Pedro Pujante, Elías Delgado
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of glucose homeostasis and can lead to different vascular comorbidities through life. In this study we aimed to analyse the circulating miRNA expression
Externí odkaz:
https://doaj.org/article/febdc309e48c4797a83ffe81cfc36d89
Autor:
Annalisa Roberti, Juan Ramon Tejedor, Irene Díaz-Moreno, Virginia López, Pablo Santamarina-Ojeda, Raúl F. Pérez, Rocío G. Urdinguio, Carmen Concellón, María Luz Martínez-Chantar, Juan Luis Fernández-Morera, Antonio Díaz-Quintana, Vicente del Amo, Agustín F. Fernández, Mario F. Fraga
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Obesity is associated with adipose tissue dysfunction through the differentiation and expansion of pre-adipocytes to adipocytes (hyperplasia) and/or increases in size of pre-existing adipocytes (hypertrophy). A cascade of transcriptional eve
Externí odkaz:
https://doaj.org/article/5b1c299332d248fc92d7d790de6608c0
Autor:
Constanza Contreras-Jurado, Ana Montero-Pedrazuela, Raúl F. Pérez, Susana Alemany, Mario F. Fraga, Ana Aranda
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionPluripotent stem cells can be generated from somatic cells by the Yamanaka factors Oct4, Sox2, Klf4 and c-Myc.MethodsMouse embryonic fibroblasts (MEFs) were transduced with the Yamanaka factors and generation of induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/6366b2de718d42d8b3910fa03ab197f5