Zobrazeno 1 - 10
of 230
pro vyhledávání: '"A. F. Dulhunty"'
Autor:
Connor H. O’ Meara, Lucy A. Coupland, Farzaneh Kordbacheh, Benjamin J. C. Quah, Chih-Wei Chang, David A. Simon Davis, Anna Bezos, Anna M. Browne, Craig Freeman, Dillon J. Hammill, Pradeep Chopra, Gergely Pipa, Paul D. Madge, Esther Gallant, Courtney Segovis, Angela F. Dulhunty, Leonard F. Arnolda, Imogen Mitchell, Levon M. Khachigian, Ross W. Stephens, Mark von Itzstein, Christopher R. Parish
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Histones, proteins that bind DNA, are toxic for pathogens outside cells but can also cause multi-organ damage as seen in sepsis. Here the authors develop small negatively charged molecules that can be used as histone antidotes, and show that they imp
Externí odkaz:
https://doaj.org/article/47652de3a653433fb4ea511fb90437ea
Autor:
Angela F. Dulhunty
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The cardiac ryanodine receptor Ca2+ release channel (RyR2) is inserted into the membrane of intracellular sarcoplasmic reticulum (SR) myocyte Ca2+ stores, where it releases the Ca2+ essential for contraction. Mutations in proteins involved in Ca2+ si
Externí odkaz:
https://doaj.org/article/50af978ae96142d88223587c63877036
Autor:
Samantha C. Salvage, Esther M. Gallant, James A. Fraser, Christopher L.-H. Huang, Angela F. Dulhunty
Publikováno v:
Cells, Vol 10, Iss 8, p 2101 (2021)
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide monotherapy, with occasion
Externí odkaz:
https://doaj.org/article/12b0086340ef4a9d97b22ca81ade3e50
Autor:
Samantha C. Salvage, Angela F. Dulhunty, Kamalan Jeevaratnam, Antony P. Jackson, Christopher L.-H. Huang
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
Skeletal and cardiac muscle excitation–contraction coupling commences with Na v 1.4/Na v 1.5-mediated, surface and transverse (T-) tubular, action potential generation. This initiates feedforward , allosteric or Ca 2+ -mediated, T-sarcoplasmic reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a79966169d65e7ffb649bd0730f693d7
https://doi.org/10.1098/rstb.2022.0162
https://doi.org/10.1098/rstb.2022.0162
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
Cardiac ryanodine receptors (RyR2) release the Ca 2+ from intracellular stores that is essential for cardiac myocyte contraction. The ion channel opening is tightly regulated by intracellular factors, including the FK506 binding proteins, FKBP12 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1698a7fe365be92e1935829f81c1c3
https://doi.org/10.1098/rstb.2022.0169
https://doi.org/10.1098/rstb.2022.0169
Publikováno v:
F1000Research, Vol 7 (2018)
The ryanodine receptor calcium release channel is central to cytoplasmic Ca2+ signalling in skeletal muscle, the heart, and many other tissues, including the central nervous system, lymphocytes, stomach, kidney, adrenal glands, ovaries, testes, thymu
Externí odkaz:
https://doaj.org/article/1af642e869854b2c84a226a872a16493
Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (NaV1.5), has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated sarcoplasmic reticulum (SR) Ca2+ release. It has been introduced as a clinical antiarr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ff34ac9cf10e3da3f21fdec0d40f
https://www.repository.cam.ac.uk/handle/1810/343885
https://www.repository.cam.ac.uk/handle/1810/343885
Autor:
Dmitry Shishmarev, Emily Rowland, Shouvik Aditya, Srinivasan Sundararaj, Aaron J. Oakley, Angela F. Dulhunty, Marco G. Casarotto
Publikováno v:
Protein Science. 31
Excitation-contraction coupling (ECC) is the physiological process in which an electrical signal originating from the central nervous system is converted into muscle contraction. In skeletal muscle tissue, the key step in the molecular mechanism of E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd4797b0fd3af0888031a6d45862e7a
https://doi.org/10.1002/pro.4311
https://doi.org/10.1002/pro.4311
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162415 (2016)
The cardiac ryanodine receptor (RyR2) is an intracellular ion channel that regulates Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling in the heart. The glutathione transferases (GSTs) are a family of phase II d
Externí odkaz:
https://doaj.org/article/6ed2d91727c74af68a1447490b4726f5
Publikováno v:
Journal of General Physiology. 154
The P2328S mutation in mice is associated with arrhythmia and spontaneous diastolic calcium release in atrial and ventricular myocytes and there is a corresponding leftward shift in the Ca2+-activation curve for mutant RYR2 channels from homozygous m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaee9198241c37cdc77a47d408a4ad2a
https://doi.org/10.1085/jgp.2021ecc42
https://doi.org/10.1085/jgp.2021ecc42