Zobrazeno 1 - 10 of 640 pro vyhledávání: '"A. F. Dawson"'
1
Akademický článek
Identification of novel p-cresol inhibitors that reduce Clostridioides difficile’s ability to compete with species of the gut microbiome
Autor: Mark A. Harrison, Rebecca J. Farthing, Nyasha Allen, Lucy M. Ahern, Kristian Birchall, Michael Bond, Harparkash Kaur, Brendan W. Wren, Julien R. C. Bergeron, Lisa F. Dawson
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Treatment of Clostridioides difficile infection (CDI) is expensive and complex, with a high proportion of patients suffering infection relapse (20–35%), and some having multiple relapses. A healthy, unperturbed gut microbiome provides colo
Externí odkaz: https://doaj.org/article/626593c26e0f40ee86a76ba8bb599235
Zobrazit plný text záznamu
2
Akademický článek
A gradient of force generation at rest differentiates cardiomyopathy outcomes with variants of actin located at the same residue
Autor: Michael R. Jones, Chau Tran, Jaskerat Singh, John F. Dawson
Publikováno v: Journal of Molecular and Cellular Cardiology Plus, Vol 2, Iss , Pp 100023- (2022)
The calcium sensitivity hypothesis helps explain the development of different forms of cardiomyopathy: increased sensitivity to calcium in cardiac sarcomeres leads to hypertrophic cardiomyopathy (HCM) and decreased sensitivity results in dilated card
Externí odkaz: https://doaj.org/article/ab79b1dff05b4d13ab4edab8ffec345f
Zobrazit plný text záznamu
3
Akademický článek
Extracellular DNA, cell surface proteins and c-di-GMP promote biofilm formation in Clostridioides difficile
Autor: Lisa F. Dawson, Johann Peltier, Catherine L. Hall, Mark A. Harrison, Maria Derakhshan, Helen A. Shaw, Neil F. Fairweather, Brendan W. Wren
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract Clostridioides difficile is the leading cause of nosocomial antibiotic-associated diarrhoea worldwide, yet there is little insight into intestinal tract colonisation and relapse. In many bacterial species, the secondary messenger cyclic-di-G
Externí odkaz: https://doaj.org/article/3426c1f132e64372a7ef52d5c7c83e91
Zobrazit plný text záznamu
5
Akademický článek
Production of p-cresol by Decarboxylation of p-HPA by All Five Lineages of Clostridioides difficile Provides a Growth Advantage
Autor: Mark A. Harrison, Harparkash Kaur, Brendan W. Wren, Lisa F. Dawson
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and is capable of causing severe symptoms, such as pseudomembranous colitis and toxic megacolon. An unusual feature of C. difficile is the distinctive production of high
Externí odkaz: https://doaj.org/article/d2b32a23f7504ba8b731b21ef2b094b9
Zobrazit plný text záznamu
6
The impact of supportive leadership on employee outcomes during organizational mergers: An organizational-level field study
Autor: Steffen R. Giessner, Jeremy F. Dawson, Kate E. Horton, Michael West
Publikováno v: Journal of Applied Psychology, 108(4), 686-697. American Psychological Association Inc.
Journal of Applied Psychology. American Psychological Association Inc.
Past merger and acquisition research has reported mixed findings on the impact of mergers on workforces. To address these ambiguities and advance merger research at the organizational level of analysis, we present a natural quasi-experiment focusing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10950164753839ed253890389f965909
https://doi.org/10.1037/apl0001042
Zobrazit plný text záznamu
7
Akademický článek
Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A systematic review and meta-analysis of randomised controlled trials.
Autor: Julieta Galante, Claire Friedrich, Anna F Dawson, Marta Modrego-Alarcón, Pia Gebbing, Irene Delgado-Suárez, Radhika Gupta, Lydia Dean, Tim Dalgleish, Ian R White, Peter B Jones
Publikováno v: PLoS Medicine, Vol 18, Iss 1, p e1003481 (2021)
BackgroundThere is an urgent need for mental health promotion in nonclinical settings. Mindfulness-based programmes (MBPs) are being widely implemented to reduce stress, but a comprehensive evidence synthesis is lacking. We reviewed trials to assess
Externí odkaz: https://doaj.org/article/afa50576fd394fbd9b899de444c5d5f1
Zobrazit plný text záznamu
8
Akademický článek
Homology-Directed Repair in Zebrafish: Witchcraft and Wizardry?
Autor: Kendal Prill, John F. Dawson
Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2020)
Introducing desired mutations into the genome of model organisms is a priority for all research focusing on protein function and disease modeling. The need to create stable mutant lines has resulted in the rapid advancement of genetic techniques over
Externí odkaz: https://doaj.org/article/7e150d802ba143a8b68fab3df9bc6bfb
Zobrazit plný text záznamu
9
Akademický článek
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
Autor: Vaibhav B. Patel, Pavel Zhabyeyev, Xueyi Chen, Faqi Wang, Manish Paul, Dong Fan, Brent A. McLean, Ratnadeep Basu, Pu Zhang, Saumya Shah, John F. Dawson, W. Glen Pyle, Mousumi Hazra, Zamaneh Kassiri, Saugata Hazra, Bart Vanhaesebroeck, Christopher A. McCulloch, Gavin Y. Oudit
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytosk
Externí odkaz: https://doaj.org/article/e70a2475a25a49f6b0fbaaaa812f41c8
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje