Zobrazeno 1 - 10
of 2 246
pro vyhledávání: '"A. F. Clarke"'
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer
Autor:
Huiru Bai, Xiaoqin Liu, Meizhen Lin, Yuan Meng, Ruolan Tang, Yajing Guo, Nan Li, Michael F. Clarke, Shang Cai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cancer incidence escalates exponentially with advancing age; however, the underlying mechanism remains unclear. In this study, we build a chronological molecular clock at single-cell transcription level with a mammary stem cell-enriched popu
Externí odkaz:
https://doaj.org/article/2f743c9e9f6049009e0b9844ae471a07
Publikováno v:
Frontiers in Psychology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/5927acdfddf344b7938747f0729d43f0
Publikováno v:
Frontiers in Psychology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/5c5bcc845eb14ba485f8620dde426dbf
Autor:
Alasdair D. F. Clarke, Anna Nowakowska, Kyle Sauerberger, David A. Rosenbaum, Thomas R. Zentall, Amelia R. Hunt
Publikováno v:
Royal Society Open Science, Vol 11, Iss 4 (2024)
How do we decide where to search for a target? Optimal search relies on first considering the relative informational value of different locations and then executing eye movements to the best options. However, many participants consistently move their
Externí odkaz:
https://doaj.org/article/128dcf57772b4b96bf7d01eadeb376e1
Autor:
Xiaomei I. Liu, André Dallmann, Kristina Brooks, Brookie M. Best, Diana F. Clarke, Mark Mirochnick, John N. van denAnker, Edmund V. Capparelli, Jeremiah D. Momper
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 148-153 (2023)
Abstract Pregnant individuals are at high risk for severe illness from COVID‐19, and there is an urgent need to identify safe and effective therapeutics for this population. Remdesivir (RDV) is a SARS‐CoV‐2 nucleotide analog RNA polymerase inhi
Externí odkaz:
https://doaj.org/article/d52f04c0444447639aa5582982613a39
Autor:
Linda J. vanWeele, Sabra I. Djomehri, Shang Cai, Jane Antony, Shaheen S. Sikandar, Dalong Qian, William H. D. Ho, Robert B. West, Ferenc A. Scheeren, Michael F. Clarke
Publikováno v:
Molecular Oncology, Vol 16, Iss 17, Pp 3128-3145 (2022)
As precision medicine increases the response rate of treatment, tumors frequently bypass inhibition, and reoccur. In order for treatment to be effective long term, the mechanisms enabling treatment adaptation need to be understood. Here, we report a
Externí odkaz:
https://doaj.org/article/8d6bdff9fa234733908de5b2990ded0f
Autor:
Nikunjkumar Patel, James F. Clarke, Farzaneh Salem, Tariq Abdulla, Frederico Martins, Sumit Arora, Eleftheria Tsakalozou, Arran Hodgkinson, Omid Arjmandi‐Tash, Sinziana Cristea, Priyanka Ghosh, Khondoker Alam, Sam G. Raney, Masoud Jamei, Sebastian Polak
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 1060-1084 (2022)
Abstract Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and tria
Externí odkaz:
https://doaj.org/article/afd2ab177bf7434a8488d0d0e8d82e93
Autor:
Abbas Babajani-Feremi, Haatef Pourmotabbed, William A. Schraegle, Clifford S. Calley, Dave F. Clarke, Andrew C. Papanicolaou
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionThe single equivalent current dipole (sECD) is the standard clinical procedure for presurgical language mapping in epilepsy using magnetoencephalography (MEG). However, the sECD approach has not been widely used in clinical assessments, m
Externí odkaz:
https://doaj.org/article/6c679f2351134371a95503f9c2d68215
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Despite increasing interest in the association between mindfulness and reduced trauma vulnerability, and the use of mindfulness in the latest interventions for Post-Traumatic Stress Disorder (PTSD), few studies have examined the m
Externí odkaz:
https://doaj.org/article/265244b8862f45dd975bb707cf4c564a
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010997 (2023)
[This corrects the article DOI: 10.1371/journal.pcbi.1009813.].
Externí odkaz:
https://doaj.org/article/3374b80d83fa42d5b32ce567a294157e