Výsledky vyhledávání - "A. Esteve Codina"

Akademický článek

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction

Autor: Tomàs Montserrat-Ayuso, Anna Esteve-Codina

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)

Abstract The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we will show that prominent initiatives suc

Externí odkaz: https://doaj.org/article/b7495d4103354d2fa1b293659de3b278

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Akademický článek

Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of untreatable disorders known as primary mitochondrial diseases (MD). Leigh syndrome (LS) is the most common pediatric MD and is characterized by progressive ne

Externí odkaz: https://doaj.org/article/622861ac6cc14a5babd24370dd72d435

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Akademický článek

Clinical and molecular characterization of steatotic liver disease in the setting of immune-mediated inflammatory diseases

Publikováno v: JHEP Reports, Vol 6, Iss 10, Pp 101167- (2024)

Background & Aims: Growing evidence suggests an increased prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in the context of immune-mediated inflammatory diseases (IMIDs). We aimed to clinically and mechanistically chara

Externí odkaz: https://doaj.org/article/73d0406276524442b466f5562ec05320

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Akademický článek

Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation

Autor: Valentina Casella, Eva Domenjo-Vila, Anna Esteve-Codina, Mireia Pedragosa, Paula Cebollada Rica, Enric Vidal, Ivan de la Rubia, Cristina López-Rodríguez, Gennady Bocharov, Jordi Argilaguet, Andreas Meyerhans

Publikováno v: Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)

Abstract Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that contribute to these fates are described, the critical control points and the mechanisms that underlie infection fa

Externí odkaz: https://doaj.org/article/dd0fc59a75174ebaada2f5ec64e26ee9

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Akademický článek

Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation

Autor: M. C. Martinez-Campanario, Marlies Cortés, Alazne Moreno-Lanceta, Lu Han, Chiara Ninfali, Verónica Domínguez, María J. Andrés-Manzano, Marta Farràs, Anna Esteve-Codina, Carlos Enrich, Francisco J. Díaz-Crespo, Belén Pintado, Joan C. Escolà-Gil, Pablo García de Frutos, Vicente Andrés, Pedro Melgar-Lesmes, Antonio Postigo

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macrophages increase atherosclerotic pl

Externí odkaz: https://doaj.org/article/4d6ce7e1890e4d409029a5183b07f6a2

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Akademický článek

Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation

Autor: Marlies Cortés, Agnese Brischetto, M. C. Martinez-Campanario, Chiara Ninfali, Verónica Domínguez, Sara Fernández, Raquel Celis, Anna Esteve-Codina, Juan J. Lozano, Julia Sidorova, Gloria Garrabou, Anna-Maria Siegert, Carlos Enrich, Belén Pintado, Manuel Morales-Ruiz, Pedro Castro, Juan D. Cañete, Antonio Postigo

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells. The anti-diabetic drug Metformin inh

Externí odkaz: https://doaj.org/article/655d9568306f4699a3a035f4045e67b7

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