Zobrazeno 1 - 10
of 86
pro vyhledávání: '"A. Elisabeth Sauer-Eriksson"'
Autor:
Hasan Tükenmez, Pardeep Singh, Souvik Sarkar, Melike Çakır, Ana H. Oliveira, Cecilia Lindgren, Karolis Vaitkevicius, Mari Bonde, A. Elisabeth Sauer-Eriksson, Fredrik Almqvist, Jörgen Johansson
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Listeria monocytogenes is a facultative Gram-positive bacterium that causes listeriosis, a severe foodborne disease. We previously discovered that ring-fused 2-pyridone compounds can decrease virulence factor expression in Listeria by bindin
Externí odkaz:
https://doaj.org/article/186a437a48004ee2be0dba97c78a2add
Autor:
Irina Iakovleva, Michael Hall, Melanie Oelker, Linda Sandblad, Intissar Anan, A. Elisabeth Sauer-Eriksson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Systemic ATTR amyloidosis causes the abnormal accumulation of ATTR fibrils formed from the human plasma protein transthyretin (TTR) in multiple organs including the eye. Here, the authors present a 3.2 Å cryo-EM structure of an ATTR fibril isolated
Externí odkaz:
https://doaj.org/article/205058912dca45fe996644a0164ffb89
Autor:
Thao Thanh Tran, Carmen D. Mathmann, Marcela Gatica-Andrades, Rachel F. Rollo, Melanie Oelker, Johanna K. Ljungberg, Tam T. K. Nguyen, Alina Zamoshnikova, Lalith K. Kummari, Orry J. K. Wyer, Katharine M. Irvine, Javier Melo-Bolívar, Annette Gross, Darren Brown, Jeffrey Y. W. Mak, David P. Fairlie, Karl A. Hansford, Matthew A. Cooper, Rabina Giri, Veronika Schreiber, Shannon R. Joseph, Fiona Simpson, Timothy C. Barnett, Jörgen Johansson, Wendy Dankers, James Harris, Timothy J. Wells, Ronan Kapetanovic, Matthew J. Sweet, Eleanor A. Latomanski, Hayley J. Newton, Romain J. R. Guérillot, Abderrahman Hachani, Timothy P. Stinear, Sze Ying Ong, Yogeswari Chandran, Elizabeth L. Hartland, Bostjan Kobe, Jennifer L. Stow, A. Elisabeth Sauer-Eriksson, Jakob Begun, Jessica C. Kling, Antje Blumenthal
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator Prf
Externí odkaz:
https://doaj.org/article/66dd0ab76b8e4e24a1aee04a59d0cdfa
Autor:
Emilia Krypotou, Mariela Scortti, Christin Grundström, Melanie Oelker, Ben F. Luisi, A. Elisabeth Sauer-Eriksson, José Vázquez-Boland
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1815-1827.e5 (2019)
Summary: To optimize fitness, pathogens selectively activate their virulence program upon host entry. Here, we report that the facultative intracellular bacterium Listeria monocytogenes exploits exogenous oligopeptides, a ubiquitous organic N source,
Externí odkaz:
https://doaj.org/article/dc2d68857c334db6b00d754374d93fac
Autor:
Magnus Wolf-Watz, Christian Hedberg, Christin Grundström, Per Rogne, Kwangho Nam, Jack Goodman, A. Elisabeth Sauer-Eriksson, Marie Rosselin, Beata Dulko-Smith
Publikováno v:
Biochemistry
ATP and GTP are exceptionally important molecules in biology with multiple, and often discrete, functions. Therefore, enzymes that bind to either of them must develop robust mechanisms to selectively utilize one or the other. Here, this specific prob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd82c53dd3660a61efb80ea7e53305f
https://doi.org/10.1021/acs.biochem.0c00549
https://doi.org/10.1021/acs.biochem.0c00549
Autor:
Pia Osterman, Erik Johansson, A. Elisabeth Sauer-Eriksson, Vimal Parkash, Göran O. Bylund, Josy ter Beek
Publikováno v:
'Nucleic Acids Research ', vol: 47, pages: 5712-5722 (2019)
Nucleic Acids Research
Nucleic Acids Research
DNA polymerase epsilon (Pol epsilon), the major leading-strand DNA polymerase in eukaryotes, has a catalytic subunit (Pol2) and three non-catalytic subunits. The N-terminal half of Pol2 (Pol2(CORE)) exhibits both polymerase and exonuclease activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e702e251deca519c4a8ffa76dfbd3f
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:52801
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:52801
Autor:
Ingeborg van der Lingen, Afshan Begum, Marie Lindgren, Fredrik Almqvist, Christin Grundström, Kristoffer Brännström, Andrew G. Cairns, Jörgen Johansson, Uwe Sauer, Sabine Hansen, Michael N. Hall, Martina Kulén, A. Elisabeth Sauer-Eriksson
Publikováno v:
Journal of Medicinal Chemistry. 61:4165-4175
Listeria monocytogenes is a bacterial pathogen that controls much of its virulence through the transcriptional regulator PrfA. In this study, we describe structure-guided design and synthesis of a set of PrfA inhibitors based on ring-fused 2-pyridone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fef36b22d6b64b0f5d2c9709ef65fe5
https://doi.org/10.1021/acs.jmedchem.8b00289
https://doi.org/10.1021/acs.jmedchem.8b00289
Autor:
Afshan Begum, Christin Grundström, Erik Chorell, Sabine Hansen, Christopher Andersson, Moritz S. Niemiec, Fredrik Almqvist, A. Elisabeth Sauer-Eriksson, James A. D. Good, Pernilla Wittung-Stafshede, Jessica Wall, Uwe Sauer, K. Syam Krishnan, Karolis Vaitkevicius, Jörgen Johansson
Publikováno v:
Cell Chemical Biology
Summary The transcriptional activator PrfA, a member of the Crp/Fnr family, controls the expression of some key virulence factors necessary for infection by the human bacterial pathogen Listeria monocytogenes. Phenotypic screening identified ring-fus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58674b1cdc7e5721780d36acdcec1be3
http://europepmc.org/articles/PMC4802734
http://europepmc.org/articles/PMC4802734
Publikováno v:
Biophysical Journal. 118:193a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e561b4d552c8f8385e5b2e9d3426203
https://doi.org/10.1016/j.bpj.2019.11.1168
https://doi.org/10.1016/j.bpj.2019.11.1168
Autor:
A. Elisabeth Sauer-Eriksson, Christin Grundström, Irina Iakovleva, Patrik L. Andersson, Mikael J. Lindberg, Kristoffer Brännström, Anders Olofsson, Jin Zhang
Publikováno v:
Environmental sciencetechnology. 52(20)
Thyroid-disrupting chemicals (TDCs) are xenobiotics that can interfere with the endocrine system and cause adverse effects in organisms and their offspring. TDCs affect both the thyroid gland and regulatory enzymes associated with thyroid hormone hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb67b729fc3b649082986540c7ab7d3c
https://pubmed.ncbi.nlm.nih.gov/30226982
https://pubmed.ncbi.nlm.nih.gov/30226982