Zobrazeno 1 - 10
of 56
pro vyhledávání: '"A. E. Solow"'
Autor:
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A. Boghdeh, Do H.N. Tran, Courtney A. Cohen, Jacquelyn A. Brown, Kathleen E. Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy Khalil, Kevin Chiem, Luis Martinez-Sobrido, John M. Dye, Benjamin A. Pinsky, Pradipta Ghosh, Soumita Das, David E. Solow-Cordero, Jing Jin, John P. Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated th
Externí odkaz:
https://doaj.org/article/9cc9d935abdc4025aa6c81ab75a6d932
Autor:
Wei Chen, Pingting Liu, Dong Liu, Haoliang Huang, Xue Feng, Fang Fang, Liang Li, Jian Wu, Liang Liu, David E. Solow-Cordero, Yang Hu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
ER stress is associated with various neurodegenerative diseases. This study found that FDA approved drug, maprotiline, inhibits histamine receptor H1-mediated ER stress and provides significant neuroprotection in mouse glaucoma model.
Externí odkaz:
https://doaj.org/article/dd3ca727977d4eaab1ecad19f6b088c6
Autor:
Albert C. Koong, Quynh-Thu Le, Amato J. Giaccia, Nicholas C. Denko, Constantinos Koumenis, Diego A.S. Toesca, David E. Solow-Cordero, Purvesh Khatri, Dadi Jiang, Jing Zhang, Zhifen Yang
Validation of the screen hits (continued).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ccbf9626d82feb706855428e58bf2c
https://doi.org/10.1158/1541-7786.22512736.v1
https://doi.org/10.1158/1541-7786.22512736.v1
Autor:
Albert C. Koong, Quynh-Thu Le, Amato J. Giaccia, Nicholas C. Denko, Constantinos Koumenis, Diego A.S. Toesca, David E. Solow-Cordero, Purvesh Khatri, Dadi Jiang, Jing Zhang, Zhifen Yang
Table representing the effects of the four individual siRNAs tested during secondary screen (deconvolution).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27095861abade06de0d5fcf9cffdb80
https://doi.org/10.1158/1541-7786.22512721.v1
https://doi.org/10.1158/1541-7786.22512721.v1
Autor:
Albert C. Koong, Maho Niwa, Quynh-Thu Le, Amato J. Giaccia, Nicholas C. Denko, Pek Y. Lum, David E. Solow-Cordero, Margaret M. Kozak, Aparna Gupta, Michael P. Hay, Muthuraman Alagappan, Arvin B. Tam, Dadi Jiang
The Supplementary Material contains additional characterization for the compounds mentioned in the paper. We have provided melting point, 1H NMR and low resolution mass spectrometry data as well as HPLC purity for these known compounds. We have also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a22946057ba1e4e044375218054437
https://doi.org/10.1158/1535-7163.22503138.v1
https://doi.org/10.1158/1535-7163.22503138.v1
Autor:
Albert C. Koong, Quynh-Thu Le, Amato J. Giaccia, Nicholas C. Denko, Constantinos Koumenis, Diego A.S. Toesca, David E. Solow-Cordero, Purvesh Khatri, Dadi Jiang, Jing Zhang, Zhifen Yang
Activation of the unfolded protein response (UPR) signaling pathways is linked to multiple human diseases, including cancer. The inositol-requiring kinase 1α (IRE1α)–X-box binding protein 1 (XBP1) pathway is the most evolutionarily conserved of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7181cd5b02073ec52e5627bd54e1ac99
https://doi.org/10.1158/1541-7786.c.6540322.v1
https://doi.org/10.1158/1541-7786.c.6540322.v1
Autor:
Caitlin M. Rodriguez, Sophia C. Bechek, Graham L. Jones, Lisa Nakayama, Tetsuya Akiyama, Garam Kim, David E. Solow-Cordero, Stephen M. Strittmatter, Aaron D. Gitler
Publikováno v:
Cell Rep
SummaryGene-based therapeutic strategies to lower ataxin-2 levels are emerging for neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type 2 (SCA2). To identify additional ways of reducing ataxin-2 levels, we pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df587bcfdfc4b1cdfdefa2f4f418783
https://doi.org/10.1101/2021.12.20.473562
https://doi.org/10.1101/2021.12.20.473562
Autor:
Wei Chen, Pingting Liu, Dong Liu, Haoliang Huang, Xue Feng, Fang Fang, Liang Li, Jian Wu, Liang Liu, David E. Solow-Cordero, Yang Hu
Publikováno v:
Nature communications. 13(1)
When the protein or calcium homeostasis of the endoplasmic reticulum (ER) is adversely altered, cells experience ER stress that leads to various diseases including neurodegeneration. Genetic deletion of an ER stress downstream effector, CHOP, signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d52d1eb1a14288f871be024ab5ddd1
https://pubmed.ncbi.nlm.nih.gov/36357388
https://pubmed.ncbi.nlm.nih.gov/36357388
Publikováno v:
Proceedings of the National Academy of Sciences. 116:18009-18014
Citrus greening disease, also known as huanglongbing (HLB), is the most devastating disease of Citrus worldwide. This incurable disease is caused primarily by the bacterium Candidatus Liberibacter asiaticus and spread by feeding of the Asian Citrus P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::685d48cf4febf36bc9f7a746c7b22ce9
https://doi.org/10.1073/pnas.1905149116
https://doi.org/10.1073/pnas.1905149116
Autor:
Sara Bolin, David E. Solow-Codero, Teresa Purzner, Ryan T. Nitta, Ginikachi Nwagbo, Emily Luo, Peyman Samghabadi, Gordon Li, Parvir S. Aujla, Yoon Jae Cho
Publikováno v:
Oncogene
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73aea1d04854ec06d3e0d4c182d32820
http://europepmc.org/articles/PMC6800621
http://europepmc.org/articles/PMC6800621