Zobrazeno 1 - 10
of 1 178
pro vyhledávání: '"A. E. Schindler"'
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 40, Iss 8, Pp 692-698 (2024)
Abstract Alzheimer disease (AD) and Alzheimer Disease and Related Dementias (AD/ADRD) are growing public health challenges globally affecting millions of older adults, necessitating concerted efforts to advance our understanding and management of the
Externí odkaz:
https://doaj.org/article/7ca63bf5ca914d209e6167f65cf0aac7
Autor:
Aurore Delvenne, Charysse Vandendriessche, Johan Gobom, Marlies Burgelman, Pieter Dujardin, Clint De Nolf, Betty M. Tijms, Charlotte E. Teunissen, Suzanne E. Schindler, Frans Verhey, Inez Ramakers, Pablo Martinez-Lage, Mikel Tainta, Rik Vandenberghe, Jolien Schaeverbeke, Sebastiaan Engelborghs, Ellen De Roeck, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Roosmarijn E. Vandenbroucke, Stephanie J. B. Vos
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background Structural and functional changes of the choroid plexus (ChP) have been reported in Alzheimer’s disease (AD). Nonetheless, the role of the ChP in the pathogenesis of AD remains largely unknown. We aim to unravel the relation bet
Externí odkaz:
https://doaj.org/article/7c5db71c472645af80c01089faaa997c
Autor:
Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N. Do, Yun Ju Sung, Guoyan Zhao, John C. Morris, Krista Moulder, David M. Holtzman, Randall J. Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E. Schindler, Joyce (Joy) Balls-Berry, Tammie L. S. Benzinger, Richard J. Perrin, Andrea Denny, B. Joy Snider, Susan L. Stark, Laura Ibanez, Carlos Cruchaga
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-19 (2024)
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer
Externí odkaz:
https://doaj.org/article/1469c9617a64436fbff15b0d11b166cb
Autor:
Chengjie Xiong, Jingqin Luo, David A. Wolk, Leslie M. Shaw, Erik D. Roberson, Charles F. Murchison, Rachel L. Henson, Tammie L. S. Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N. Gremminger, Krista L. Moulder, David S. Geldmacher, Olivio J. Clay, Ganesh Babulal, Carlos Cruchaga, David M. Holtzman, Randall J. Bateman, John C. Morris, Suzanne E. Schindler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers
Externí odkaz:
https://doaj.org/article/7e17f1f8091f4e35b67e41ede981da17
Publikováno v:
Data in Brief, Vol 57, Iss , Pp 110902- (2024)
Rainbow trout (Oncorhynchus mykiss) is a dominant aquaculture species of the Salmonidae family, native only to the North Pacific. Recently, the gut microbiome has been shown to reflect the health status and responses to environmental changes in farme
Externí odkaz:
https://doaj.org/article/39ca61f567d6478b9363306887e09698
Autor:
Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown. We performed comprehensive proteogenomic analyses using the large
Externí odkaz:
https://doaj.org/article/1615926b14294de6baba893a22aea0f8
Examining heterogeneity in dementia using data-driven unsupervised clustering of cognitive profiles.
Autor:
Sayantan Kumar, Inez Y Oh, Suzanne E Schindler, Nupur Ghoshal, Zachary Abrams, Philip R O Payne
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0313425 (2024)
Dementia is characterized by a decline in memory and thinking that is significant enough to impair function in activities of daily living. Patients seen in dementia specialty clinics are highly heterogenous with a variety of different symptoms that p
Externí odkaz:
https://doaj.org/article/6f99029f5cf04027874f9d1c3343da57
Autor:
Gengsheng Chen, Nicole S. McKay, Brian A. Gordon, Jingxia Liu, Nelly Joseph-Mathurin, Suzanne E. Schindler, Jason Hassenstab, Andrew J. Aschenbrenner, Qing Wang, Stephanie A. Schultz, Yi Su, Pamela J LaMontagne, Sarah J. Keefe, Parinaz Massoumzadeh, Carlos Cruchaga, Chengjie Xiong, John C. Morris, Tammie L.S. Benzinger
Publikováno v:
NeuroImage: Clinical, Vol 41, Iss , Pp 103551- (2024)
The use of biomarkers for the early detection of Alzheimer’s disease (AD) is crucial for developing potential therapeutic treatments. Positron Emission Tomography (PET) is a well-established tool used to detect β-amyloid (Aβ) plaques in the brain
Externí odkaz:
https://doaj.org/article/55129f96597543b38eb932e438ce93d5
Autor:
Abby L. Brand, Paige E. Lawler, James G. Bollinger, Yan Li, Suzanne E. Schindler, Melody Li, Samir Lopez, Vitaliy Ovod, Akinori Nakamura, Leslie M. Shaw, Henrik Zetterberg, Oskar Hansson, Randall J. Bateman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer’s disease (AD). Detection of Aβ pathology is essential for AD diagnosis and for identifying and recruiting research participants for clinical
Externí odkaz:
https://doaj.org/article/8c259ae810b94ba58cff71f6b550e1ac
Autor:
Andrew J. Aschenbrenner, Yan Li, Rachel L. Henson, Katherine Volluz, Jason Hassenstab, Philip Verghese, Tim West, Matthew R. Meyer, Kristopher M. Kirmess, Anne M. Fagan, Chengjie Xiong, David Holtzman, John C. Morris, Randall J. Bateman, Suzanne E. Schindler
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 11, Pp 1739-1751 (2022)
Abstract Objectives Concentrations of amyloid‐β peptides (Aβ42/Aβ40) and neurofilament light (NfL) can be measured in plasma or cerebrospinal fluid (CSF) and are associated with Alzheimer’s disease brain pathology and cognitive impairment. Thi
Externí odkaz:
https://doaj.org/article/8f7c8d145d2b4e17b9754fd515d4d64c