Zobrazeno 1 - 10
of 184
pro vyhledávání: '"A. E. Roher"'
Autor:
Chera L. Maarouf, Thomas G. Beach, Charles H. Adler, Michael Malek-Ahmadi, Tyler A. Kokjohn, Brittany N. Dugger, Douglas G. Walker, Holly A. Shill, Sandra A. Jacobson, Marwan N. Sabbagh, Alex E. Roher, Arizona Parkinson’s Disease Consortium
Publikováno v:
Biomarker Insights, Vol 2013, Iss 8, Pp 19-28 (2013)
Externí odkaz:
https://doaj.org/article/ba82b901892b43109a92a0ea6c402445
Autor:
Chera L Maarouf, Tyler A Kokjohn, Douglas G Walker, Charisse M Whiteside, Walter M Kalback, Alexis Whetzel, Lucia I Sue, Geidy Serrano, Sandra A Jacobson, Marwan N Sabbagh, Eric M Reiman, Thomas G Beach, Alex E Roher
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105784 (2014)
Defining the biochemical alterations that occur in the brain during "normal" aging is an important part of understanding the pathophysiology of neurodegenerative diseases and of distinguishing pathological conditions from aging-associated changes. Th
Externí odkaz:
https://doaj.org/article/3f4835cd1a07417d822f3b2bc489143a
Autor:
Alex E Roher, David H Cribbs, Ronald C Kim, Chera L Maarouf, Charisse M Whiteside, Tyler A Kokjohn, Ian D Daugs, Elizabeth Head, Carolyn Liebsack, Geidy Serrano, Christine Belden, Marwan N Sabbagh, Thomas G Beach
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59735 (2013)
The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis. Viewing amyloid deposits as the prime instigator of dementia has now led to clinical trials of m
Externí odkaz:
https://doaj.org/article/e1f712923df14ed6badcf2a6efbd1aa7
Autor:
Jesse M Hunter, Jason Kwan, Michael Malek-Ahmadi, Chera L Maarouf, Tyler A Kokjohn, Christine Belden, Marwan N Sabbagh, Thomas G Beach, Alex E Roher
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36893 (2012)
Key pathological hallmarks of Alzheimer's disease (AD), including amyloid plaques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles do not completely account for cognitive impairment, therefore other factors such as cardiovascular and ce
Externí odkaz:
https://doaj.org/article/08c3112e9ddb407289691128ca81b8c9
Autor:
Chera L Maarouf, Ian D Daugs, Tyler A Kokjohn, Douglas G Walker, Jesse M Hunter, Jane C Kruchowsky, Randy Woltjer, Jeffrey Kaye, Eduardo M Castaño, Marwan N Sabbagh, Thomas G Beach, Alex E Roher
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27291 (2011)
The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while e
Externí odkaz:
https://doaj.org/article/67725ef0a8a346f5a8e6df781ffcb964
Autor:
P. Charukeshi Chandrasekera, George Perry, Robin S.B. Williams, Ann Lam, Alex E. Roher, Martha Clare Morris, Thomas Hartung, David Pamies, Ryan Merkley, Francesca Pistollato, Neal D. Barnard, Thomas J. Novak, Mei-Chun Lai, Gillian R. Langley, Elan L. Ohayon, Eugenia Trushina, Stevan Harnad
Publikováno v:
Oncotarget
Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b808a704c1a414db36dce71b0696b3
https://doi.org/10.18632/oncotarget.9175
https://doi.org/10.18632/oncotarget.9175
Publikováno v:
Journal of Alzheimer's Disease. 50:645-658
Studies of presenilin (PSEN) gene mutations producing early onset Alzheimer's disease (AD) have helped elucidate the pathogenic mechanisms of dementia and guided clinical trials of potential therapeutic interventions. Although familial and sporadic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609283e28e1d1b12720c46d08a4d1cd0
https://doi.org/10.3233/jad-150757
https://doi.org/10.3233/jad-150757
Autor:
Alex E. Roher, Thomas G. Beach, Michael J. Pontecorvo, Lucia I. Sue, Abhinay D. Joshi, Chera L. Maarouf, Ming Lu, Geidy E. Serrano, Anthony Intorcia
Publikováno v:
Journal of Alzheimer's disease : JAD. 61(4)
Amyloid imaging demonstrates the in vivo presence of amyloid-β (Aβ) deposits in the aging human brain but it is still unknown which structural forms and modifications of Aβ are detected. In Alzheimer's disease, most amyloid deposits are predominan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dab67fd4cf7f2d56e8eeca9c73f119
https://pubmed.ncbi.nlm.nih.gov/29376867
https://pubmed.ncbi.nlm.nih.gov/29376867
Autor:
Joel Pullen, Jessica Filon, Sarah Scott, Douglas G. Walker, Richard J. Caselli, Geidy E. Serrano, Megan Saxon-LaBelle, John N. Caviness, Charles H. Adler, Thomas G. Beach, Alex C. Birdsill, Joseph G. Hentz, Marwan N. Sabbagh, Sandra Jacobson, Michael Malek-Ahmadi, Lisa D. Gale, Brittany Hoffman, Angelica Garcia, Brittany N. Dugger, Alexander Scroggins, Lih-Fen Lue, Geoffrey L. Ahern, Bryan K. Woodruff, Jiong Shi, Chera L. Maarouf, Anthony Intorcia, Lisa R. Nicholson, Anna D. Burke, Jessica Powell, Kathryn J. Davis, Alex E. Roher, Lucia I. Sue, Eric M. Reiman, Christine Belden, Kathy E. Long, Holly A. Shill, Erika Driver-Dunckley, Steven Z. Rapscak
Publikováno v:
Neuropathology. 35:354-389
The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain-only donations and currently has banked more than 1600 brains. More than 430 whole-body donatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad55f5c5c4b681be1ab2f698268ccd3
https://doi.org/10.1111/neup.12189
https://doi.org/10.1111/neup.12189