Zobrazeno 1 - 10
of 140
pro vyhledávání: '"A. E. Moor"'
Autor:
Kristina Handler, Karsten Bach, Costanza Borrelli, Salvatore Piscuoglio, Xenia Ficht, Ilhan E. Acar, Andreas E. Moor
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cells collectively determine biological functions by communicating with each other—both through direct physical contact and secreted factors. Consequently, the local microenvironment of a cell influences its behavior, gene expression, and
Externí odkaz:
https://doaj.org/article/18203f2954534ac1a9e9ce527ec8635f
Autor:
Anamaria Balic, Dilara Perver, Pierfrancesco Pagella, Hubert Rehrauer, Bernd Stadlinger, Andreas E. Moor, Viola Vogel, Thimios A. Mitsiadis
Publikováno v:
International Journal of Oral Science, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Carious lesions are bacteria-caused destructions of the mineralised dental tissues, marked by the simultaneous activation of immune responses and regenerative events within the soft dental pulp tissue. While major molecular players in tooth
Externí odkaz:
https://doaj.org/article/67124b26f1804da2806dfb211a557197
Autor:
Pierfrancesco Pagella, Laura deVargas Roditi, Bernd Stadlinger, Andreas E. Moor, Thimios A. Mitsiadis
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 10, Pp 1433-1445 (2021)
Abstract The Notch signaling pathway is a fundamental regulator of cell fate determination in homeostasis and regeneration. In this work, we aimed to determine how Notch signaling mediates the interactions between perivascular stem cells and their ni
Externí odkaz:
https://doaj.org/article/5f7843a74d9c4f86a5b1e0aa634ca8c0
Autor:
Costanza Borrelli, Tomas Valenta, Kristina Handler, Karelia Vélez, Alessandra Gurtner, Giulia Moro, Atefeh Lafzi, Laura de Vargas Roditi, George Hausmann, Isabelle C. Arnold, Andreas E. Moor, Konrad Basler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
How downstream regulators of Wnt/β-catenin signalling control the fate of intestinal epithelial stem cells (IESCs) is unclear. Here, the authors show that the transcriptional co-factors interacting with the N- and C-terminal domains of β-catenin di
Externí odkaz:
https://doaj.org/article/b000084e9fe54599bffafb79714d42b4
Autor:
Hassan Massalha, Keren Bahar Halpern, Samir Abu‐Gazala, Tamar Jana, Efi E Massasa, Andreas E Moor, Lisa Buchauer, Milena Rozenberg, Eli Pikarsky, Ido Amit, Gideon Zamir, Shalev Itzkovitz
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp 1-18 (2020)
Abstract Malignant cell growth is fueled by interactions between tumor cells and the stromal cells composing the tumor microenvironment. The human liver is a major site of tumors and metastases, but molecular identities and intercellular interactions
Externí odkaz:
https://doaj.org/article/c1d13de27e154463b8e3601a5983c967
Autor:
Keren Bahar Halpern, Hassan Massalha, Rachel K. Zwick, Andreas E. Moor, David Castillo-Azofeifa, Milena Rozenberg, Lydia Farack, Adi Egozi, Dan R. Miller, Inna Averbukh, Yotam Harnik, Noa Weinberg-Corem, Frederic J. de Sauvage, Ido Amit, Ophir D. Klein, Michal Shoshkes-Carmel, Shalev Itzkovitz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Epithelial gene expression has been shown to be zonated along the crypt-villus axis, but mechanisms shaping this spatial variability were unknown. Here, Bahar Halpern et al. uncover zonation of mesenchymal cells, including Lgr5+ telocytes, which regu
Externí odkaz:
https://doaj.org/article/06a4059134d14359ba2c09cd1b2ad006
Autor:
Bahar Degirmenci, Cansu Dincer, Habibe Cansu Demirel, Linda Berkova, Andreas E. Moor, Abdullah Kahraman, George Hausmann, Michel Aguet, Nurcan Tuncbag, Tomas Valenta, Konrad Basler
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103369- (2021)
Summary: Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells
Externí odkaz:
https://doaj.org/article/7d5fcf03a27a4c14bb1db2d84c671f91
Autor:
Pierfrancesco Pagella, Laura de Vargas Roditi, Bernd Stadlinger, Andreas E. Moor, Thimios A. Mitsiadis
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102405- (2021)
Summary: Teeth exert fundamental functions related to mastication and speech. Despite their great biomedical importance, an overall picture of their cellular and molecular composition is still missing. In this study, we have mapped the transcriptiona
Externí odkaz:
https://doaj.org/article/f87fbda8b7ac4d2999c72f9b5ce35784
Autor:
Dario Zimmerli, Costanza Borrelli, Amaia Jauregi-Miguel, Simon Söderholm, Salome Brütsch, Nikolaos Doumpas, Jan Reichmuth, Fabienne Murphy-Seiler, MIchel Aguet, Konrad Basler, Andreas E Moor, Claudio Cantù
Publikováno v:
eLife, Vol 9 (2020)
BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes. They have been proposed as therapeutic targets to diminish Wnt signaling output in intestinal malignancies. Here we find that, in colorectal cancer cells and i
Externí odkaz:
https://doaj.org/article/0517c11da9ad45b3956adb42bdc3b2d1
Autor:
Sarah E Moor, MSc, Andrew K Tusubira, MPH, Ann R Akiteng, MPH, Evelyn Hsieh, MD, Christine Ngaruiya, MD, Tracy L Rabin, MD, Nicola L Hawley, PhD, Kasia J Lipska, MD, Mari Armstrong-Hough, PhD, Christine K Nalwadda, PhD, Rachel Nugent, PhD, Robert Kalyesubula, MMed, Isaac Ssinabulya, MMed, Jeremy I Schwartz, MD
Publikováno v:
The Lancet Global Health, Vol 8, Iss , Pp S22- (2020)
Background: In 2020, non-communicable diseases (NCDs) currently account for 40% of deaths in east Africa and are expected to surpass communicable diseases as the leading causes of death in sub-Saharan Africa by 2030. However, there remain many gaps i
Externí odkaz:
https://doaj.org/article/69955f0caae14864b92ab836bdbc65b5