Zobrazeno 1 - 10
of 599
pro vyhledávání: '"A. E. Mercer"'
Autor:
Hany F. Sobhi, Kelly E. Mercer, Renny S. Lan, Laxmi Yeruva, Gabriella A.M. Ten Have, Nicolaas E.P. Deutz, Brian D. Piccolo, Jean Debédat, Lindsay M. Pack, Sean H. Adams
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 10, Pp 100632- (2024)
Microbe-produced molecules (xenometabolites) found in foods or produced by gut microbiota are increasingly implicated in microbe-microbe and microbe-host communication. Xenolipids, in particular, are a class of metabolites for which the full catalog
Externí odkaz:
https://doaj.org/article/bc7ad95ec7e9473a80bc454a46f14b84
Autor:
Pam Takhar, Marc Geirnaert, Scott Gavura, Jaclyn Beca, Rebecca E. Mercer, Avram Denburg, Caroline Muñoz, Mina Tadrous, Ambica Parmar, Francois Dionne, Darryl Boehm, Carole Chambers, Erica Craig, Maureen Trudeau, Matthew C. Cheung, Joanne Houlihan, Valerie McDonald, Petros Pechlivanoglou, Marianne Taylor, Eric Wasylenko, Wiesława Dominika Wranik, Kelvin K. W. Chan
Publikováno v:
Current Oncology, Vol 31, Iss 4, Pp 1876-1898 (2024)
Multi-criteria decision analysis (MCDA) is a value assessment tool designed to help support complex decision-making by incorporating multiple factors and perspectives in a transparent, structured approach. We developed an MCDA rating tool, consisting
Externí odkaz:
https://doaj.org/article/8cbdb12baeaa4a1eacebc73b853c3a3f
Autor:
Yanling Ma, Hong Cai, Julia Smith, Ching-Hsuen Chu, Stephen E. Mercer, Stephanie Boehm, Ivar Mcdonald, Bradley Zinker, Dong Cheng
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100514- (2024)
Human genetic evidence suggests a protective role of loss-of-function variants in 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) for liver fibrotic diseases. Although there is limited preclinical experimental data on Hsd17b13 antisense oligonucle
Externí odkaz:
https://doaj.org/article/961d2ae3e8bd48ffa4f295bbb6a4f902
Autor:
Brandon Lu, Wei Fang Dai, Ruth Croxford, Wanrudee Isaranuwatchai, Jaclyn Beca, Ines B. Menjak, Teresa M. Petrella, Nicole Mittmann, Craig C. Earle, Scott Gavura, Rebecca E. Mercer, Timothy P. Hanna, Kelvin K. W. Chan
Publikováno v:
Cancer Medicine, Vol 12, Iss 10, Pp 11451-11461 (2023)
Abstract Background The efficacy‐effectiveness gap between randomized trial and real‐world evidence regarding the clinical benefit of ipilimumab for metastatic melanoma (MM) has been well characterized by previous literature, consistent with init
Externí odkaz:
https://doaj.org/article/f0604d85f42d4d3396b6316504533bac
Autor:
Ambica Parmar, Wei Fang Dai, Francois Dionne, Marc Geirnaert, Avram Denburg, Tarry Ahuja, Jaclyn Beca, Sylvie Bouchard, Carole Chambers, Melissa J. Hunt, Don Husereau, Elena Lungu, Valerie McDonald, Rebecca E. Mercer, Gunita Mitera, Caroline Muñoz, Rohini Naipaul, Stuart Peacock, Tanya Potashnik, Mina Tadrous, Pam Takhar, Marianne Taylor, Maureen Trudeau, Danica Wasney, Scott Gavura, Kelvin K. W. Chan
Publikováno v:
Current Oncology, Vol 30, Iss 4, Pp 3776-3786 (2023)
The Canadian Real-world Evidence for Value of Cancer Drugs (CanREValue) collaboration developed an MCDA rating tool to assess and prioritize potential post-market real-world evidence (RWE) questions/uncertainties emerging from public drug funding dec
Externí odkaz:
https://doaj.org/article/4fb575f2c14545e7887f622958f92f21
Autor:
Amy Easton, Marianne L. Jensen, Congwei Wang, Peter H. Hagedorn, Yuwen Li, Michael Weed, Jere E. Meredith, Valerie Guss, Kelli Jones, Martin Gill, Carol Krause, Jeffrey M. Brown, Lisa Hunihan, Joanne Natale, Alda Fernandes, Yifeng Lu, Joe Polino, Mark Bookbinder, Greg Cadelina, Yulia Benitex, Ramola Sane, John Morrison, Dieter Drexler, Stephen E. Mercer, Charlotte Bon, Nikhil J. Pandya, Ravi Jagasia, Tai-Hsien Ou Yang, Tania Distler, Fiona Grüninger, Michael Meldgaard, Marco Terrigno, John E. Macor, Charles F. Albright, James Loy, Anja M. Hoeg, Richard E. Olson, Angela M. Cacace
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 625-642 (2022)
Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of hyperphosphorylated, aggregated tau. Because tau pathology can be distinct a
Externí odkaz:
https://doaj.org/article/b93757f19dfa46c987c592a3e606bdbe
Autor:
Sk Imran Hossain, Sudipta Singha Roy, Jocelyn De Goër De Herve, Robert E. Mercer, Engelbert Mephu Nguifo
Publikováno v:
Data in Brief, Vol 48, Iss , Pp 109249- (2023)
Occlusion of skin lesions in dermoscopic images due to hair affects the performance of computer-assisted lesion analysis algorithms. Lesion analysis can benefit from digital hair removal or realistic hair simulation techniques. To assist in that proc
Externí odkaz:
https://doaj.org/article/46bdae9281154f449aa32f06f14388f4
Publikováno v:
Environmental Challenges, Vol 11, Iss , Pp 100717- (2023)
Sanitation systems involving onsite storage of faecal matter cause excreta to undergo transformation and primary treatment in-situ. However, little is known about the transformation pathway followed by fresh faeces while contained in situ. The curren
Externí odkaz:
https://doaj.org/article/75e6cce9120e4ad98dab101bae90cfbf
Autor:
Wei Fang Dai, Claire de Oliveira, Scott Blommaert, Reka E. Pataky, David Tran, Zeb Aurangzeb, Cynthia Kendell, Chris Folkins, Chandy Somayaji, Jeff Dowden, Winson Cheung, Erin Strumpf, Jaclyn M. Beca, Carol McClure, Robin Urquhart, James Ted McDonald, Riaz Alvi, Donna Turner, Stuart Peacock, Avram Denburg, Rebecca E. Mercer, Caroline Muñoz, Ambica Parmar, Mina Tadrous, Pam Takhar, Kelvin K. W. Chan, on behalf of the CanREValue Collaboration
Publikováno v:
Current Oncology, Vol 29, Iss 3, Pp 2046-2063 (2022)
Canadian provinces routinely collect patient-level data for administrative purposes. These real-world data (RWD) can be used to generate real-world evidence (RWE) to inform clinical care and healthcare policy. The CanREValue Collaboration is developi
Externí odkaz:
https://doaj.org/article/b4db62942dc7480d850936adb09a42d1
Autor:
Wei Fang Dai, Erica Craig, Brent Fraser, Alex Chambers, Helen Mai, M. Bryson Brown, Craig C. Earle, William K. Evans, Marc Geirnaert, Marianne Taylor, Maureen Trudeau, Daniel Sperber, Jaclyn M. Beca, Avram Denburg, Rebecca E. Mercer, Ambica Parmar, Mina Tadrous, Pam Takhar, Kelvin K. W. Chan, on behalf of the CanREValue Collaboration
Publikováno v:
Current Oncology, Vol 28, Iss 6, Pp 4645-4654 (2021)
The CanREValue Collaboration established the Reassessment & Uptake Working Group to develop a preliminary process to reassess funded cancer drugs in Canada. A simulated exercise was conducted to evaluate the proposed reassessment process using a real
Externí odkaz:
https://doaj.org/article/524acb9fb32b4ff39d6c84874e0c7e30