GNSS Radio Occultation Data in the AWS Cloud

Autor: S. S. Leroy, A. E. McVey, S. M. Leidner, H. Zhang, H. Gleisner

Publikováno v: Earth and Space Science, Vol 11, Iss 2, Pp n/a-n/a (2024)

Abstract Radio occultation (RO) by the Earth's atmosphere of the transmitted signals of the Global Navigation Satellite Systems' satellites has improved numerical weather prediction, has benefited atmospheric process studies, and benchmarked climate

Externí odkaz: https://doaj.org/article/f6c12fda374f49db838f7c9c2dbef17f

MLL1 is regulated by KSHV LANA and is important for virus latency

Autor: Bing Liu, Ángel L Álvarez, Qiming Sun, J. Pedro Simas, Min Tan, Franceline Juillard, Rute Chitas, Han Xue, Agnieszka Szymula, Colin E. McVey, Shijun Li, Tânia F Custódio, Kenneth M. Kaye, Jing Huang, She Chen

Publikováno v: Nucleic Acids Research
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
'Nucleic Acids Research ', vol: 49, pages: 12895-12911 (2021)

Mixed lineage leukemia 1 (MLL1) is a histone methyltransferase. Kaposi's sarcoma-associated herpesvirus (KSHV) is a leading cause of malignancy in AIDS. KSHV latently infects tumor cells and its genome is decorated with epigenetic marks. Here, we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a39c13d981db8b2599fb8c50312893c
http://europepmc.org/articles/PMC8682764

Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.

Autor: Bruno Correia, Sofia A Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, Lénia Rodrigues, Thomas R Schneider, Maria A Carrondo, Kenneth M Kaye, J Pedro Simas, Colin E McVey

Publikováno v: PLoS Pathogens, Vol 9, Iss 10, p e1003673 (2013)

Latency-associated nuclear antigen (LANA) mediates γ2-herpesvirus genome persistence and regulates transcription. We describe the crystal structure of the murine gammaherpesvirus-68 LANA C-terminal domain at 2.2 Å resolution. The structure reveals

Externí odkaz: https://doaj.org/article/e9ab2330f422454c8330e6d4aa52cb19

In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4

Autor: J. Pedro Simas, Marta Pires de Miranda, Colin E. McVey, Kenneth M. Kaye, Ana Patrícia Quendera

Publikováno v: Journal of Virology

KSHV is a human oncogenic virus for which there is no tractable, immunocompetent animal model of infection. MuHV-4, a related rodent gammaherpesvirus, enables pathogenesis studies in mice. In latency, both viruses persist as extrachromosomal, circula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d8347912289606b860d1bf746f4e0
http://europepmc.org/articles/PMC6189500

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autor: Maria Arménia Carrondo, Tania F. Custodio, J. Pedro Simas, Bruno Correia, Colin E. McVey, Maxim V. Petoukhov, Kenneth M. Kaye, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Dmitri I. Svergun, Marta Pires de Miranda

Publikováno v: Nucleic Acids Research
'Nucleic Acids Research ', vol: 43, pages: 10039-10054 (2015)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nucleic acids symposium series 43(20), 10039 (2015). doi:10.1093/nar/gkv987

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/), whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ba6de49b8066ed5145848304a11cac
http://europepmc.org/articles/PMC4787769