Zobrazeno 1 - 10
of 206
pro vyhledávání: '"A. E. McKinnon"'
Autor:
John E. McKinnon, Joel Santiaguel, Claudia Murta de Oliveira, Dongzi Yu, Mukhy Khursheed, Flavie Moreau, Lena Klopp‐Schulze, Jamie Shaw, Sanjeev Roy, Amy H. Kao, the ANEMONE Study Team
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2640-2653 (2023)
Abstract Enpatoran is a selective inhibitor of toll‐like receptors 7 and 8 (TLR7/8) that potentially targets pro‐inflammatory pathways induced by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). A phase II study conducted in Braz
Externí odkaz:
https://doaj.org/article/dac7d19bf3f140e78fae2fdc00bbf872
A Small Device May Deliver King-Sized Solutions for Patients With an Exacerbation of Cystic Fibrosis
Publikováno v:
International Journal of Pediatrics, Vol 2024 (2024)
Conclusion:Results from the study suggest that children hospitalised for exacerbations of CF are more active if they receive antibiotics via a spring-infusor device compared with a SIP, and have reduced hospital stay that results in cost saving to th
Externí odkaz:
https://doaj.org/article/5b7d36ad884745e2b201e058ea0e0f89
Autor:
Xiaoyu Fu, Da Cheng, Zhenwu Luo, Sonya L. Heath, Ruth Adekunle, John E McKinnon, Lisa Martin, Zizhang Sheng, Enrique Espinosa, Wei Jiang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background . Up to 20% of people with HIV (PWH) who undergo virologically suppressed antiretroviral therapy (ART) fail to experience complete immune restoration. We recently reported that plasma anti-CD4 IgG (antiCD4IgG) autoantibodies from
Externí odkaz:
https://doaj.org/article/00b2ab0e983f40cf815a445cc05446ab
Autor:
Adrian F Hernandez, David R Boulware, Radha Rajasingham, Christopher W Woods, Kevin J Anstrom, Ravi Amaravadi, Benjamin S Abella, Hwanhee Hong, Anne Friedland, Mengyi Hu, Susan Halabi, John E McKinnon, Jorge Rojas-Serrano, Angélica Margarita Portillo-Vázquez, Susanna Naggie
Publikováno v:
BMJ Open, Vol 13, Iss 6 (2023)
Objective We studied the safety and efficacy of hydroxychloroquine (HCQ) as pre-exposure prophylaxis for COVID-19 in healthcare workers (HCWs), using a meta-analysis of randomised controlled trials (RCTs).Data sources PubMed and EMBASE databases were
Externí odkaz:
https://doaj.org/article/10d79c6e96d6445e963962280b7084b7
Autor:
John E. McKinnon, Dee Dee Wang, Marcus Zervos, Matt Saval, Laurie Marshall-Nightengale, Paul Kilgore, Pardeep Pabla, Ed Szandzik, Kathleen Maksimowicz-McKinnon, William W. O'Neill
Publikováno v:
International Journal of Infectious Diseases, Vol 116, Iss , Pp 167-173 (2022)
Background: Health care workers (HCW) are among the highest risk groups for acquisition of COVID-19 because of occupational exposures. The WHIP COVID-19 Study aimed to evaluate the safety and efficacy of hydroxychloroquine (HCQ) as chemoprophylaxis f
Externí odkaz:
https://doaj.org/article/87534f802e834e48aad028e376fb1c46
Autor:
Justin D. Finkle, Hala Boulos, Terri M. Driessen, Christine Lo, Richard A. Blidner, Ashraf Hafez, Aly A. Khan, Ariane Lozac’hmeur, Kelly E. McKinnon, Jason Perera, Wei Zhu, Afshin Dowlati, Kevin P. White, Robert Tell, Nike Beaubier
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-12 (2021)
Abstract Liquid biopsy is a valuable precision oncology tool that is increasingly used as a non-invasive approach to identify biomarkers, detect resistance mutations, monitor disease burden, and identify early recurrence. The Tempus xF liquid biopsy
Externí odkaz:
https://doaj.org/article/439e514d758c4462a85579f192a11c43
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-6 (2021)
Abstract BRCA-mutant cancers often develop therapeutic resistance through several mechanisms. Here, we report a case of pathogenic germline BRCA2-driven breast cancer monitored for disease progression and acquired resistance using longitudinal multi-
Externí odkaz:
https://doaj.org/article/36355c8205f84120b0841747327b4cc3
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 21, Iss 4, Pp 517-530 (2020)
The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine stor
Externí odkaz:
https://doaj.org/article/55365a581aca443eaca2bf710a0a06f8
Autor:
Samia Arshad, Paul Kilgore, Zohra S. Chaudhry, Gordon Jacobsen, Dee Dee Wang, Kylie Huitsing, Indira Brar, George J. Alangaden, Mayur S. Ramesh, John E. McKinnon, William O’Neill, Marcus Zervos, Varidhi Nauriyal, Asif Abdul Hamed, Owais Nadeem, Jennifer Swiderek, Amanda Godfrey, Jeffrey Jennings, Jayna Gardner-Gray, Adam M. Ackerman, Jonathan Lezotte, Joseph Ruhala, Raef Fadel, Amit Vahia, Smitha Gudipati, Tommy Parraga, Anita Shallal, Gina Maki, Zain Tariq, Geehan Suleyman, Nicholas Yared, Erica Herc, Johnathan Williams, Odaliz Abreu Lanfranco, Pallavi Bhargava, Katherine Reyes
Publikováno v:
International Journal of Infectious Diseases, Vol 97, Iss , Pp 396-403 (2020)
Significance: The United States is in an acceleration phase of the COVID-19 pandemic. Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies. Objective: The pu
Externí odkaz:
https://doaj.org/article/f63e94b59bf1451cb9ceace2ebd92ec1
Autor:
Brian M. Larsen, Madhavi Kannan, Lee F. Langer, Benjamin D. Leibowitz, Aicha Bentaieb, Andrea Cancino, Igor Dolgalev, Bridgette E. Drummond, Jonathan R. Dry, Chi-Sing Ho, Gaurav Khullar, Benjamin A. Krantz, Brandon Mapes, Kelly E. McKinnon, Jessica Metti, Jason F. Perera, Tim A. Rand, Veronica Sanchez-Freire, Jenna M. Shaxted, Michelle M. Stein, Michael A. Streit, Yi-Hung Carol Tan, Yilin Zhang, Ende Zhao, Jagadish Venkataraman, Martin C. Stumpe, Jeffrey A. Borgia, Ashiq Masood, Daniel V.T. Catenacci, Jeremy V. Mathews, Demirkan B. Gursel, Jian-Jun Wei, Theodore H. Welling, Diane M. Simeone, Kevin P. White, Aly A. Khan, Catherine Igartua, Ameen A. Salahudeen
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109429- (2021)
Summary: Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer biology and develop novel precision medicine therapeutics. However, utilizing TOs for systems-biology-based approaches has been limited by a lack of s
Externí odkaz:
https://doaj.org/article/9e05120e2cf8481abf4978520140395c