Výsledky vyhledávání - "A. E. M. Mayen"

Successful short-term ex vivo expansion of NOD/SCID repopulating ability and CAFC week 6 from umbilical cord blood

Autor: Robert Ploemacher, Angelique E. M. Mayen, P. L. Van Soest, Nuray Kusadasi, J. L. M. Koevoet

Publikováno v: Leukemia, 14, 1944-1953. Nature Publishing Group

In view of the limited potential for rapid hematological recovery after transplantation of umbilical cord blood cells (UCB) in adults, we have attempted to expand CD34+ selected hemopoietic stem cells (HSC) and progenitors in 2-week cultures of whole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c726b2508711ac12c006af6f7a40534d
https://doi.org/10.1038/sj.leu.2401917

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Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells

Autor: Rob E. Ploemacher, Angelique E. M. Mayen, Jose A. Cancelas, Alexandra E. de Koning, Wendy Koevoet, Elwin J. C. Rombouts

Publikováno v: Blood. 96:498-505

Gap junctions (GJs) provide for a unique system of intercellular communication (IC) allowing rapid transport of small molecules from cell to cell. GJs are formed by a large family of proteins named connexins (Cxs). Cx43 has been considered as the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef6ef61dc365e2db10dc4ecfbb6649b
https://doi.org/10.1182/blood.v96.2.498

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Gap Junction Intercellular Communication is Likely to be Involved in Regulation of Stroma-dependent Proliferation of Hemopoietic Stem Cells

Autor: Tibor Krenacs, Rob E. Ploemacher, Martin Rosendaal, Angelique E. M. Mayen, Alexandra E. de Koning

Publikováno v: Hematology. 5:133-147

The 80-100 fold increased immunohistological expression of the Gap Junction (GJ) protein Connexin-43 in murine bone marrow during the neonatal period and directly following cytoreductive treatment of adult mice suggests that the regulation of stem ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15916f3d6e535a3e2b5a5dda59e65015
https://doi.org/10.1080/10245332.2000.11746498

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Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia–derived Mutation in the G-CSF Receptor Gene

Autor: Angelique E. M. Mayen, Alister C. Ward, Ivo P. Touw, Rob E. Ploemacher, Claudia Antonissen, Mirjam H. A. Hermans

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, 189(4), 683-691. Rockefeller University Press

In approximately 20% of cases of severe congenital neutropenia (SCN), mutations are found in the gene encoding the granulocyte colony-stimulating factor receptor (G-CSF–R). These mutations introduce premature stop codons, which result in truncation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8636b17b10e871386d2f3f8d4e8685b2
https://doi.org/10.1084/jem.189.4.683

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Stroma-Contact Prevents Loss of Hematopoietic Stem Cell Quality During Ex Vivo Expansion of CD34+ Mobilized Peripheral Blood Stem Cells

Autor: D. A. Breems, Karen E. Siebel, Angelique E. M. Mayen, Ellen A.W. Blokland, Rob E. Ploemacher, Lilian J.A. Engels

Publikováno v: Blood. 91:111-117

Stroma-supported long-term cultures (LTC) allow estimation of stem cell quality by simultaneous enumeration of hematopoietic stem cell (HSC) frequencies in a graft using the cobblestone area forming cell (CAFC) assay, and the ability of the graft to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f7ca37003d11a657ad6bc4f5511251
https://doi.org/10.1182/blood.v91.1.111.111_111_117

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Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells

Autor: Angelique E. M. Mayen, Shanta Mancham, Samantha Hol, Bob Löwenberg, Rob E. Ploemacher, Ruud Delwel, Yolanda Vankan, Peter J. M. Valk, Sandra E. Verbakel

Publikováno v: Blood. 90:1448-1457

We recently demonstrated that the gene encoding the peripheral cannabinoid receptor (Cb2) may be a proto-oncogene involved in murine myeloid leukemias. We show here that Cb2 may have a role in hematopoietic development. RNAse protection analysis show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fab285cfb2d20c9114352598e677d374
https://doi.org/10.1182/blood.v90.4.1448

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Does transmembrane communication through gap junctions enable stem cells to overcome stromal inhibition?

Autor: T Dunina-Barkovskaya, Angelique E. M. Mayen, Robert Ploemacher, Tibor Krenacs, A de Koning, Martin Rosendaal

Publikováno v: Leukemia, 1281-1289. Nature Publishing Group
ISSUE=11;STARTPAGE=1281;ENDPAGE=1289;ISSN=0887-6924;TITLE=Leukemia

When long-term bone marrow cultures are treated with Amphotericin B (AB) their haemopoietic stem cells (HSC) cease growing. This is not a toxic effect of the drug because once that is removed, HSC resume clonal growth and, given sufficient time, form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0971202176a2b3e9fd6a8e1aa478b4
https://doi.org/10.1038/sj.leu.2400744

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High-level expression of the ER-MP58 antigen on mouse bone marrow hematopoietic progenitor cells marks commitment to the myeloid lineage

Autor: W. Van Ewijk, Walentina A. T. Slieker, A. E. M. Mayen, Rob E. Ploemacher, Pieter J. M. Leenen, Jane S. A. Voerman, M. F. T. R. De Bruijn

Publikováno v: European Journal of Immunology, 26(12), 2850-2858. Wiley-VCH

Studies on the early events in the differentiation of the nonspecific immune system require the identification and isolation of myeloid-committed progenitor cells. Using the monoclonal antibodies (mAb) ER-MP12 and ER-MP20, generated against immortali

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https://doi.org/10.1002/eji.1830261208

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T cells and macrophages in Trypanosoma brucei-related glomerulopathy

Autor: Gert Jan Fleuren, Jan A. Bruijn, A. E. M. Mayen, N van Rooijen, E. de Heer, M L van Velthuysen

Publikováno v: Infection and Immunity. 62:3230-3235

In a previous study, susceptibility for Trypanosoma brucei-related glomerulopathy in mice was shown to be dependent on non-major histocompatibility complex genes. Glomerular disease in this model could not be explained by the production of autoantibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66d6377ec84c0c2049150ae3aa4b1f3
https://doi.org/10.1128/iai.62.8.3230-3235.1994

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Phagocytosis by glomerular endothelial cells in infection-related glomerulopathy

Autor: Gert Jan Fleuren, A. E. M. Mayen, M-L. F. van Velthuysen, Jan A. Bruijn, Frans A. Prins, E. de Heer

Publikováno v: Nephrology Dialysis Transplantation. 9:1077-1083

Glomerulonephritis in BALB/c mice following infection with Trypanosoma brucei is characterized by albuminuria and glomerular deposition of immunoglobulins. Electron-dense deposits are present in the mesangium, as well as subendothelially and subepith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fec7f9dcbf4aa4ba381193f53e6032
https://doi.org/10.1093/ndt/9.8.1077

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