Zobrazeno 1 - 10
of 1 687
pro vyhledávání: '"A. E. Fraser"'
Publikováno v:
The Astrophysical Journal, Vol 966, Iss 2, p 195 (2024)
Differentially rotating stars and planets transport angular momentum (AM) internally due to turbulence at rates that have long been a challenge to predict reliably. We develop a self-consistent saturation theory, using a statistical closure approxima
Externí odkaz:
https://doaj.org/article/aa0af534d147483da7b2c848a68cf1bc
Autor:
Tong Xu, Jason A. Junge, Alireza Delfarah, Yi-Tsung Lu, Cosimo Arnesano, Maheen Iqbal, Kevin Delijani, Tien-Chan Hsieh, Emmanuelle Hodara, Hemal H. Mehta, Pinchas Cohen, Nicholas A. Graham, Scott E. Fraser, Amir Goldkorn
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Genetic mutations have long been recognized as drivers of cancer drug resistance, but recent work has defined additional non-genetic mechanisms of plasticity, wherein cancer cells assume a drug resistant phenotype marked by altered epigeneti
Externí odkaz:
https://doaj.org/article/61124d6369024ac5a8162156b065d51c
Autor:
Jose V. Torres-Pérez, Sofia Anagianni, Aleksandra M. Mech, William Havelange, Judit García-González, Scott E. Fraser, Giorgio Vallortigara, Caroline H. Brennan
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105704- (2023)
Summary: BAZ1B is a ubiquitously expressed nuclear protein with roles in chromatin remodeling, DNA replication and repair, and transcription. Reduced BAZ1B expression disrupts neuronal and neural crest development. Variation in the activity of BAZ1B
Externí odkaz:
https://doaj.org/article/a506e2d7cf1d4d6c9c65762018cca7e3
Autor:
Patrick E Gelbach, Dongqing Zheng, Scott E Fraser, Kate L White, Nicholas A Graham, Stacey D Finley
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010555 (2022)
Pancreatic β-cells respond to increased extracellular glucose levels by initiating a metabolic shift. That change in metabolism is part of the process of glucose-stimulated insulin secretion and is of particular interest in the context of diabetes.
Externí odkaz:
https://doaj.org/article/fe77bacb0dce4ad5b98c883832f02538
Autor:
Andrea Messina, Davide Potrich, Matilde Perrino, Eva Sheardown, Maria Elena Miletto Petrazzini, Peter Luu, Anna Nadtochiy, Thai V. Truong, Valeria Anna Sovrano, Scott E. Fraser, Caroline H. Brennan, Giorgio Vallortigara
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2022)
An ability to estimate quantities, such as the number of conspecifics or the size of a predator, has been reported in vertebrates. Fish, in particular zebrafish, may be instrumental in advancing the understanding of magnitude cognition. We review her
Externí odkaz:
https://doaj.org/article/b353ca8180184b2faba3222c5bd69fee
Autor:
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the br
Externí odkaz:
https://doaj.org/article/311ee78e40194926b8b50a33d61a9ceb
Autor:
Zhongying Wang, Tatyana Gurlo, Aleksey V. Matveyenko, David Elashoff, Peiyu Wang, Madeline Rosenberger, Jason A. Junge, Raymond C. Stevens, Kate L. White, Scott E. Fraser, Peter C. Butler
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Using phasor-FLIM (Fluorescence Lifetime Imaging Microscopy), Wang et al. reveal differential usages of oxidative phosphorylation and glycolysis in living islet cells following glucose stimulation. This study suggests the applicability of FLIM as a d
Externí odkaz:
https://doaj.org/article/16706c9faa644994ba8974540e742fe0
Autor:
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E. Fraser, María-Rosario Luquin
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Protein misfolding diseases refer to a variety of disorders that develop as a consequence of the misfolding of proteins in various organs. The etiologies of Parkinson’s and Alzheimer’s disease remain unclear, but it seems that type two d
Externí odkaz:
https://doaj.org/article/7a977155641c4478bcefd6b211a7b1b5
Autor:
Natalia M. Lyra e Silva, Rafaella A. Gonçalves, Tharick A. Pascoal, Ricardo A. S. Lima-Filho, Elisa de Paula França Resende, Erica L. M. Vieira, Antonio L. Teixeira, Leonardo C. de Souza, Julyanna A. Peny, Juliana T. S. Fortuna, Isadora C. Furigo, Debora Hashiguchi, Vivian S. Miya-Coreixas, Julia R. Clarke, Jose F. Abisambra, Beatriz M. Longo, Jose Donato, Paul E. Fraser, Pedro Rosa-Neto, Paulo Caramelli, Sergio T. Ferreira, Fernanda G. De Felice
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of
Externí odkaz:
https://doaj.org/article/17556201da0949e79e2b1a92c14e9d0c
Autor:
Wen Shi, Daniel E. S. Koo, Masahiro Kitano, Hsiao J. Chiang, Le A. Trinh, Gianluca Turcatel, Benjamin Steventon, Cosimo Arnesano, David Warburton, Scott E. Fraser, Francesco Cutrale
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Spectral phasor analysis allows unmixing fluorescence microscopy images, but it requires user involvement and has a limited number of labels that can be analyzed and displayed. Here the authors present a semi-automated solution to visualise multiple
Externí odkaz:
https://doaj.org/article/f2fd3e48a18b4f268ef5c9595066fca4