Zobrazeno 1 - 10
of 218
pro vyhledávání: '"A. E. Firth"'
Autor:
Jake R. Thomas, Nagisa Yoshida, Matthew P. Brember, Anna Appios, James R. Edgar, Irving L.M.H. Aye, Betty Y.W. Chung, Andrew E. Firth, Hazel Stewart, Naomi McGovern
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background Infection during pregnancy with SARS-CoV-2 can have a serious impact on both maternal and foetal health. Clinical studies have shown that SARS-CoV-2 transmission from the mother to the foetus typically does not occur. However, there is evi
Externí odkaz:
https://doaj.org/article/1ae60cc75263461b8d062a320469e445
Autor:
A. E. Firth, B. W. Jagger, H. M. Wise, C. C. Nelson, K. Parsawar, N. M. Wills, S. Napthine, J. K. Taubenberger, P. Digard, J. F. Atkins
Publikováno v:
Open Biology, Vol 2, Iss 10 (2012)
Programmed ribosomal frameshifting is used in the expression of many virus genes and some cellular genes. In eukaryotic systems, the most well-characterized mechanism involves –1 tandem tRNA slippage on an X_XXY_YYZ motif. By contrast, the mechanis
Externí odkaz:
https://doaj.org/article/1012ec0bdaff4c22823ce4a2101b064a
Autor:
Hazel Stewart, Yongxu Lu, Sarah O’Keefe, Anusha Valpadashi, Luis Daniel Cruz-Zaragoza, Hendrik A. Michel, Samantha K. Nguyen, George W. Carnell, Nina Lukhovitskaya, Rachel Milligan, Yasmin Adewusi, Irwin Jungreis, Valeria Lulla, David A. Matthews, Stephen High, Peter Rehling, Edward Emmott, Jonathan L. Heeney, Andrew D. Davidson, James R. Edgar, Geoffrey L. Smith, Andrew E. Firth
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108080- (2023)
Summary: The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has
Externí odkaz:
https://doaj.org/article/0eb2381740c24412b7c9b4e912187e2a
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 35, Iss 9, Pp 835-844 (2022)
Potyviruses comprise the largest and most important group of plant positive-strand RNA viruses. The potyviral cell-to-cell movement protein P3N-PIPO is expressed via transcriptional slippage at a conserved GAAAAAA sequence, leading to insertion of an
Externí odkaz:
https://doaj.org/article/235f3a2feb284c94ba827a4a6beefece
Autor:
Matthew D. Parker, Hazel Stewart, Ola M. Shehata, Benjamin B. Lindsey, Dhruv R. Shah, Sharon Hsu, Alexander J. Keeley, David G. Partridge, Shay Leary, Alison Cope, Amy State, Katie Johnson, Nasar Ali, Rasha Raghei, Joe Heffer, Nikki Smith, Peijun Zhang, Marta Gallis, Stavroula F. Louka, Hailey R. Hornsby, Hatoon Alamri, Max Whiteley, Benjamin H. Foulkes, Stella Christou, Paige Wolverson, Manoj Pohare, Samantha E. Hansford, Luke R. Green, Cariad Evans, Mohammad Raza, Dennis Wang, Andrew E. Firth, James R. Edgar, Silvana Gaudieri, Simon Mallal, The COVID-19 Genomics UK (COG-UK) consortium, Mark O. Collins, Andrew A. Peden, Thushan I. de Silva
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Matthew Parker et al. use the ARTIC network tiled amplicon PCR and Oxford Nanopore sequencing of thousands of SARS-CoV-2 samples to detect subgenomic RNA changes in the B.1.1.7 lineage endemic in the UK in late 2020/early 2021. They discovered higher
Externí odkaz:
https://doaj.org/article/a4136fc5fe3f462ca4c6714d58abfce9
Autor:
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan J. Warren, Michal Minczuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Rebelo-Guiomar et al. unveil late stage assembly intermediates of the human mitochondrial ribosome by inactivating the methyltransferase MRM2 in cells. Absence of MRM2 impairs organismal homeostasis, while its catalytic activity is dispensable for mi
Externí odkaz:
https://doaj.org/article/b26a6648dba14e5181a35583967acaa7
Autor:
Chris H. Hill, Lukas Pekarek, Sawsan Napthine, Anuja Kibe, Andrew E. Firth, Stephen C. Graham, Neva Caliskan, Ian Brierley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Many RNA viruses employ programmed –1 ribosomal frameshifting (PRF) to expand their coding capacity and optimize production of viral proteins. Here, the authors report structural and biophysical analysis of protein 2A from a cardiovirus, with insig
Externí odkaz:
https://doaj.org/article/4b234d9264ef4780bb30f06b7dbc26de
Autor:
Valeria Lulla, Andrew E. Firth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Astroviruses are common human pathogens and their genomes contain three known protein-coding genes. Here, Lulla et al. report a fourth, previously overlooked gene encoding protein XP which has a viroporin-like activity that is important for efficient
Externí odkaz:
https://doaj.org/article/b52d01832d8e493da92213e3f81e0b32
Autor:
Georgia M Cook, Katherine Brown, Pengcheng Shang, Yanhua Li, Lior Soday, Adam M Dinan, Charlotte Tumescheit, AP Adrian Mockett, Ying Fang, Andrew E Firth, Ian Brierley
Publikováno v:
eLife, Vol 11 (2022)
The arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the swine industry worldwide. Here we apply ribosome profiling (RiboSeq) and parallel RNA sequencing (RNASeq) to characterise the transc
Externí odkaz:
https://doaj.org/article/5662d085bcc841788dfe368361631968
Autor:
Tomasz H Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A Stoll, Owen S Tutt, Stanislava Svobodova, Dmitri I Svergun, Neil A Bryant, Janet E Deane, Andrew E Firth, Cy M Jeffries, Colin M Crump, Stephen C Graham
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010225 (2022)
[This corrects the article DOI: 10.1371/journal.ppat.1009824.].
Externí odkaz:
https://doaj.org/article/8c201b0792ce4d5f96823b0806ce40e6