Zobrazeno 1 - 10
of 505
pro vyhledávání: '"A. E. Cowen"'
Autor:
Jessica Knox, Andrew R. Burns, Brittany Cooke, Savina R. Cammalleri, Megan Kitner, Justin Ching, Jack M. P. Castelli, Emily Puumala, Jamie Snider, Emily Koury, J. B. Collins, Salma Geissah, James J. Dowling, Erik C. Andersen, Igor Stagljar, Leah E. Cowen, Mark Lautens, Inga Zasada, Peter J. Roy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Left unchecked, plant-parasitic nematodes have the potential to devastate crops globally. Highly effective but non-selective nematicides are justifiably being phased-out, leaving farmers with limited options for managing nematode infestation
Externí odkaz:
https://doaj.org/article/609af50dc9664af39474ef0017566555
Autor:
Patricia P Peterson, Jin-Tae Choi, Ci Fu, Leah E Cowen, Sheng Sun, Yong-Sun Bahn, Joseph Heitman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 11, p e1012735 (2024)
The eukaryotic serine/threonine protein phosphatase PP2A is a heterotrimeric enzyme composed of a scaffold A subunit, a regulatory B subunit, and a catalytic C subunit. Of the four known B subunits, the B"' subunit (known as striatin) interacts with
Externí odkaz:
https://doaj.org/article/76ce23628ed84ac584bb513c642f1f2b
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103245- (2024)
Summary: Translation inhibitors have therapeutic potential against Candida species. Here, we present a protocol to measure translation inhibition in Candida spp. We describe steps for employing an alkynylated methionine analog, L-homopropargylglycine
Externí odkaz:
https://doaj.org/article/7926e69cba4c4c97b207d300ad72998c
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT At human body temperature, the fungal pathogen Candida albicans can transition from yeast to filamentous morphologies in response to host-relevant cues. Additionally, elevated temperatures encountered during febrile episodes can independentl
Externí odkaz:
https://doaj.org/article/747be2b79c0f4e14b1587775256cbb4a
Autor:
Emily H. Xiong, Xiang Zhang, Huijuan Yan, Henry N. Ward, Zhen-Yuan Lin, Cassandra J. Wong, Ci Fu, Anne-Claude Gingras, Suzanne M. Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114601- (2024)
Summary: Fungal pathogens such as Candida albicans pose a significant threat to human health with limited treatment options available. One strategy to expand the therapeutic target space is to identify genes important for pathogen growth in host-rele
Externí odkaz:
https://doaj.org/article/7a90d14f55eb4540a12239260d52e408
Publikováno v:
Ecological Solutions and Evidence, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract A key area of research in ecological statistics involves combining data sources from multiple streams to improve population estimates. One such model attempts to integrate capture–recapture and presence–absence data to estimate the popul
Externí odkaz:
https://doaj.org/article/f04f7118b96842ad8a4b1ca9edaf97bb
Autor:
Jessie MacAlpine, Martin Daniel-Ivad, Daniela Atere, Bradley Laflamme, Nicole Robbins, William W. Navarre, Justin Nodwell, Luke Whitesell, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/6367050b2ccd49b4b0437df130a6aac3
Autor:
Sara Fallah, Dustin Duncan, Kyle D. Reichl, Michael J. Smith, Wenyu Wang, John A. Porco, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTCandida albicans, one of the most prevalent human fungal pathogens, causes diverse diseases extending from superficial infections to deadly systemic mycoses. Currently, only three major classes of antifungal drugs are available to treat syste
Externí odkaz:
https://doaj.org/article/0310e0d547f54976a2f68da74ed7b338
Autor:
Jessie MacAlpine, Martin Daniel-Ivad, Zhongle Liu, Junko Yano, Nicole M. Revie, Robert T. Todd, Peter J. Stogios, Hiram Sanchez, Teresa R. O’Meara, Thomas A. Tompkins, Alexei Savchenko, Anna Selmecki, Amanda O. Veri, David R. Andes, Paul L. Fidel, Nicole Robbins, Justin Nodwell, Luke Whitesell, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/1edd977e074749009192e38dcc7e589d
Autor:
Zhongle Liu, Pauline Basso, Saif Hossain, Sean D. Liston, Nicole Robbins, Luke Whitesell, Suzanne M. Noble, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Metabolic flexibility enables fungi to invade challenging host environments. In Candida albicans, a common cause of life-threatening infections in humans, an important contributor to flexibility is alternative oxidase (Aox) activity. Dramati
Externí odkaz:
https://doaj.org/article/77916211e1fb435cbbda60aadd78443d