Zobrazeno 1 - 10
of 57
pro vyhledávání: '"A. E. Alewijnse"'
Autor:
Petra Keul, Marcel M. G. J. van Borren, Alexander Ghanem, Frank Ulrich Müller, Antonius Baartscheer, Arie O. Verkerk, Frank Stümpel, Jan Sebastian Schulte, Nazha Hamdani, Wolfgang A. Linke, Pieter van Loenen, Marek Matus, Wilhelm Schmitz, Jörg Stypmann, Klaus Tiemann, Jan‐Hindrik Ravesloot, Astrid E. Alewijnse, Sven Hermann, Léon J. A. Spijkers, Karl‐Heinz Hiller, Deron Herr, Gerd Heusch, Michael Schäfers, Stephan L. M. Peters, Jerold Chun, Bodo Levkau
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 5 (2016)
BackgroundSphingosine‐1‐phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia–reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine‐1‐phosphate receptor 1 (S1P1) in vivo is un
Externí odkaz:
https://doaj.org/article/fbf5ff26565e41e1860b0d2d29621773
Autor:
Kathinka W E M van Hooren, Léon J A Spijkers, Dorothee van Breevoort, Mar Fernandez-Borja, Ruben Bierings, Jaap D van Buul, Astrid E Alewijnse, Stephan L M Peters, Jan Voorberg
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91346 (2014)
Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells. S1P promotes endothelial cell barrier function and induces release of endothelia
Externí odkaz:
https://doaj.org/article/ecb94040bd484e56aacf2e23ee062e9c
Autor:
Léon J A Spijkers, Rob F P van den Akker, Ben J A Janssen, Jacques J Debets, Jo G R De Mey, Erik S G Stroes, Bert-Jan H van den Born, Dayanjan S Wijesinghe, Charles E Chalfant, Luke MacAleese, Gert B Eijkel, Ron M A Heeren, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21817 (2011)
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid biology is alte
Externí odkaz:
https://doaj.org/article/7ea95473f792457ab3148a3baa0d7cd5
Autor:
Léon J A Spijkers, Ben J A Janssen, Jelly Nelissen, Merlijn J P M T Meens, Dayanjan Wijesinghe, Charles E Chalfant, Jo G R De Mey, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29222 (2011)
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolate
Externí odkaz:
https://doaj.org/article/46004c2b269246d28a6a3d335037f686
Publikováno v:
British Journal of Pharmacology. 166:1411-1418
BACKGROUND AND PURPOSE FTY720 (Fingolimod) is a recently approved orally administered drug for the treatment of multiple sclerosis. Phase II and III clinical trials have demonstrated that this drug modestly increases BP. We previously showed that inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::368b9f7f1bc04e196fad29cab847c676
https://doi.org/10.1111/j.1476-5381.2012.01865.x
https://doi.org/10.1111/j.1476-5381.2012.01865.x
Autor:
Léon J. A. Spijkers, Matthijs G. Compeer, J. G. R. De Mey, Jelly Nelissen, A. E. Alewijnse, Pieter Lemkens, Nadine J.A. Mattheij, P. B. Van Loenen, Merlijn J. Meens
Publikováno v:
British Journal of Pharmacology. 166:297-308
BACKGROUND AND PURPOSE Calcitonin gene-related peptide (CGRP) has been proposed to relax vascular smooth muscle cells (VSMC) via cAMP and can promote dissociation of endothelin-1 (ET-1) from ETA receptors. The latter is not mimicked by other stimuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768fa03df7be761b71325fa9dd7f885c
https://doi.org/10.1111/j.1476-5381.2011.01774.x
https://doi.org/10.1111/j.1476-5381.2011.01774.x
Autor:
Marco Presta, Stefania Nicoli, Simone Buraschi, Chiara Tobia, Stefania Mitola, Patrizia Dell'Era, Paola Chiodelli, Pieter B. van Loenen, Efrem Foglia, Astrid E. Alewijnse
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, 32(9), E104-E116. Lippincott Williams and Wilkins
Objective— Endothelial sphingosine-1-phosphate (S1P) receptor-1 (S1P 1 ) affects different vascular functions, including blood vessel maturation and permeability. Here, we characterized the role of the zS1P 1 ortholog in vascular development in zeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613620335636c5a34e7a86811acb1f08
https://doi.org/10.1161/atvbaha.112.250035
https://doi.org/10.1161/atvbaha.112.250035
Autor:
Marcel M. G. J. van Borren, Jan G. Zegers, E. E. Verheijck, Jan Bourier, Astrid E. Alewijnse, Hanno L. Tan, Najat Hajji, Jan-Hindrik Ravesloot, Arie O. Verkerk, Stephan L. M. Peters, Ronald Wilders
Publikováno v:
Basic research in cardiology, 105(1), 73-87. D. Steinkopff-Verlag
Basic Research in Cardiology
Basic Research in Cardiology
We investigated the contribution of the intracellular calcium (Ca (i) (2+) ) transient to acetylcholine (ACh)-mediated reduction of pacemaker frequency and cAMP content in rabbit sinoatrial nodal (SAN) cells. Action potentials (whole cell perforated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229114e574aa524ed05ec8092a503450
https://doi.org/10.1007/s00395-009-0048-9
https://doi.org/10.1007/s00395-009-0048-9
Autor:
Stephan L. M. Peters, Martin C. Michel, J. van Unen, Astrid E. Alewijnse, Maikel Jongsma, P. B. Van Loenen
Publikováno v:
British Journal of Pharmacology. 156:1305-1311
Background and purpose: Recently, some ligands targeting the sphingosine-1-phosphate receptor subtype 3 (S1P 3 ) have become available. The characterization of these compounds was mainly based on one functional read-out system, although S1 P 3 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42421f24012226c7317f75d4ccadc9ef
https://doi.org/10.1111/j.1476-5381.2009.00134.x
https://doi.org/10.1111/j.1476-5381.2009.00134.x
Autor:
Mariëlle C. Hendriks-Balk, Najat Hajji, Martin C. Michel, Stephan L. M. Peters, Pieter B. van Loenen, Astrid E. Alewijnse
Publikováno v:
European journal of pharmacology, 600(1-3), 1-9. Elsevier
Sphingosine-1-phosphate (S1P) signalling via G protein-coupled receptors is important for the regulation of cell function and differentiation. Specific Regulators of G protein Signalling (RGS) proteins modulate the function of these receptors in many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e38bbb0b81aec17fbb18453e5260abb
https://doi.org/10.1016/j.ejphar.2008.09.041
https://doi.org/10.1016/j.ejphar.2008.09.041