Zobrazeno 1 - 10
of 4 623
pro vyhledávání: '"A. Dinarello"'
Autor:
N. Facchinello, T. Skobo, G. Meneghetti, E. Colletti, A. Dinarello, N. Tiso, R. Costa, G. Gioacchini, O. Carnevali, F. Argenton, L. Colombo, L. Dalla Valle
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and com
Externí odkaz:
https://doaj.org/article/5fc0ac8c9079415a80ca8b2300792049
Autor:
Martin Jaeger, Axel Dietschmann, Sophie Austermeier, Sude Dinçer, Pauline Porschitz, Larsen Vornholz, Ralph J.A. Maas, Evelien G.G. Sprenkeler, Jürgen Ruland, Stefan Wirtz, Tania Azam, Leo A.B. Joosten, Bernhard Hube, Mihai G. Netea, Charles A. Dinarello, Mark S. Gresnigt
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
ABSTRACTOur immune system possesses sophisticated mechanisms to cope with invading microorganisms, while pathogens evolve strategies to deal with threats imposed by host immunity. Human plasma protein α1-antitrypsin (AAT) exhibits pleiotropic immune
Externí odkaz:
https://doaj.org/article/69c249b8532c4a85b4278d546bfe2770
Autor:
Raquel Brañas Casas, Alessandro Zuppardo, Giovanni Risato, Alberto Dinarello, Rudy Celeghin, Camilla Fontana, Eleonora Grelloni, Alexandru Ionut Gilea, Carlo Viscomi, Andrea Rasola, Luisa Dalla Valle, Tiziana Lodi, Enrico Baruffini, Nicola Facchinello, Francesco Argenton, Natascia Tiso
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-12 (2024)
Abstract The human mitochondrial DNA polymerase gamma is a holoenzyme, involved in mitochondrial DNA (mtDNA) replication and maintenance, composed of a catalytic subunit (POLG) and a dimeric accessory subunit (POLG2) conferring processivity. Mutation
Externí odkaz:
https://doaj.org/article/58a56ab3a25547089b9f2b151454fd8b
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Decades of evidence positioned IL-1β as a master regulatory cytokine in acute and chronic inflammatory diseases. Approved biologics aimed at inhibiting IL-1 signaling have shown efficacy but variable safety. More recently, targeting NLRP3 activation
Externí odkaz:
https://doaj.org/article/efa6c2d534e9490f99a32ee57d8cbe70
Autor:
Liqiong Jiang, Lars P. Lunding, William S. Webber, Karsten Beckmann, Tania Azam, Jesper Falkesgaard Højen, Jesus Amo-Aparicio, Alberto Dinarello, Tom T. Nguyen, Ulrich Pessara, Daniel Parera, David J. Orlicky, Stephan Fischer, Michael Wegmann, Charles A. Dinarello, Suzhao Li
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MA
Externí odkaz:
https://doaj.org/article/043b9fc676264481860d024fe524374a
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 10, Pp 2189-2201 (2024)
Metabolism is a fundamental process by which biochemicals are broken down to produce energy (catabolism) or used to build macromolecules (anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate mult
Externí odkaz:
https://doaj.org/article/3d4cac3cd72b4c4c9dff25d542cb7faf
Autor:
Alberto Dinarello, Riccardo Massimiliano Betto, Linda Diamante, Annachiara Tesoriere, Rachele Ghirardo, Chiara Cioccarelli, Giacomo Meneghetti, Margherita Peron, Claudio Laquatra, Natascia Tiso, Graziano Martello, Francesco Argenton
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract STAT3 and HIF1α are two fundamental transcription factors involved in many merging processes, like angiogenesis, metabolism, and cell differentiation. Notably, under pathological conditions, the two factors have been shown to interact genet
Externí odkaz:
https://doaj.org/article/80918e40eb454fe8b3e60f3d5b9e7c75
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Parkinson’s disease (PD) is characterized by a progressive degeneration of dopaminergic neurons, which leads to irreversible loss of peripheral motor functions. Death of dopaminergic neurons induces an inflammatory response in m
Externí odkaz:
https://doaj.org/article/9e771736560b44e886618201a2fdbb1f