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Akademický článek

Attenuation of skin injury by a MARCO targeting PLGA nanoparticle

Autor: Ummiye V. Onay, Dan Xu, Dauren Biyashev, Spencer T. Evans, Michael M. Demczuk, Tobias Neef, Joseph R. Podojil, Sara Beddow, Nathan C. Gianneschi, I. Caroline Le Poole, Stephen D. Miller, Kurt Q. Lu

Publikováno v: npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-11 (2024)

Abstract Cutaneous exposure to the DNA alkylating class of chemotherapeutic agents including nitrogen mustard (NM) leads to both skin injury and systemic inflammation. Circulating myeloid subsets recruited to the skin act to further exacerbate local

Externí odkaz: https://doaj.org/article/ee72089f6b5b4526b932dafa4b2f485a

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Akademický článek

Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen allergy. However, the molecular switches leading to successful durable tolerance re

Externí odkaz: https://doaj.org/article/4241e882ff6348d9b88a6e9c30ce2b6f

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Akademický článek

Influence of the functional intervention on the development of essential social skills in children with life-limiting conditions

Autor: Agnieszka Ptak, Małgorzata Stefańska, Ewa Demczuk-Włodarczyk

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)

Abstract Life-limiting conditions often cause children to be overlooked as participants in everyday activities. For parents child development should lead to independence in daily living activity. For parents of children who are disabled, independence

Externí odkaz: https://doaj.org/article/f91de2aaec1f432abaf7e0b5ce0df818

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Akademický článek

Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

Autor: Ibrahim Hawwari, Lukas Rossnagel, Nathalia Rosero, Salie Maasewerd, Matilde B Vasconcelos, Marius Jentzsch, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Lucas S Ribeiro, Sebastian Kallabis, Felix Meissner, Moshe Arditi, Asli E Atici, Magali Noval Rivas, Bernardo S Franklin

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1901-1929 (2024)

Abstract In humans, blood Classical CD14+ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monoc

Externí odkaz: https://doaj.org/article/3f0b496722be4a4a8de3b39c4dca46e8

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Akademický článek

Concurrent BCR‐ABL1 and core binding factor beta rearrangement in de novo acute myeloid leukemia: A case report and review of literature

Autor: Brittany Salter, Sarah Ge, Amy Tam, Suzanne Demczuk, Darci Butcher, Elizabeth McCready, Dina Khalaf

Publikováno v: eJHaem, Vol 5, Iss 3, Pp 607-615 (2024)

Abstract A distinct subset of acute myeloid leukemia (AML) is characterized by the presence of the Philadelphia chromosome (Ph+), due to reciprocal translocation t(9;22)(q34;q11.2). This chromosomal rearrangement leads to the fusion of the breakpoint

Externí odkaz: https://doaj.org/article/6fee930a1c4043ce95ffd04f307d1342

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Akademický článek

Waste from the food industry: Innovations in biorefineries for sustainable use of resources and generation of value

Autor: Volpato Maroldi, Wédisley, de Andrade Arruda Fernandes, Isabela, Demczuk Junior, Bogdan, Cristina Pedro, Alessandra, Maria Maciel, Giselle, Windson Isidoro Haminiuk, Charles

Publikováno v: In Bioresource Technology December 2024 413

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Akademický článek

Topical application of synthetic melanin promotes tissue repair

Autor: Dauren Biyashev, Zofia E. Siwicka, Ummiye V. Onay, Michael Demczuk, Dan Xu, Madison K. Ernst, Spencer T. Evans, Cuong V. Nguyen, Florencia A. Son, Navjit K. Paul, Naneki C. McCallum, Omar K. Farha, Stephen D. Miller, Nathan C. Gianneschi, Kurt Q. Lu

Publikováno v: npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-14 (2023)

Abstract In acute skin injury, healing is impaired by the excessive release of reactive oxygen species (ROS). Melanin, an efficient scavenger of radical species in the skin, performs a key role in ROS scavenging in response to UV radiation and is upr

Externí odkaz: https://doaj.org/article/580d14f3b7184afc91ae92d714c186b8

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