Zobrazeno 1 - 10
of 538
pro vyhledávání: '"A. David Weaver"'
Autor:
Amy N Shore, Keyong Li, Mona Safari, Alshaima'a M Qunies, Brittany D Spitznagel, C David Weaver, Kyle Emmitte, Wayne Frankel, Matthew C Weston
Publikováno v:
eLife, Vol 13 (2024)
More than 20 recurrent missense gain-of-function (GOF) mutations have been identified in the sodium-activated potassium (KNa) channel gene KCNT1 in patients with severe developmental and epileptic encephalopathies (DEEs), most of which are resistant
Externí odkaz:
https://doaj.org/article/c400c6aeddf44a7fa69400b6b4b9e3a2
Autor:
Nigam M. Mishra, Brittany D. Spitznagel, Yu Du, Yasmeen K. Mohamed, Ying Qin, C. David Weaver, Kyle A. Emmitte
Publikováno v:
Molecules, Vol 29, Iss 23, p 5494 (2024)
Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the KCNT1 gene. KCNT1 encodes the sodium-activated potassium channel known as SLACK,
Externí odkaz:
https://doaj.org/article/97ec9fb835ab49e79c485155658686c3
Publikováno v:
Contact, Vol 7 (2024)
Calcium signal propagation from endoplasmic reticulum (ER) to mitochondria regulates a multitude of mitochondrial and cell functions, including oxidative ATP production and cell fate decisions. Ca 2+ transfer is optimal at the ER-mitochondrial contac
Externí odkaz:
https://doaj.org/article/06c04454411f40e5b415f1a68288aa74
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 November 2023 95
Autor:
Alshaima’a M. Qunies, Brittany D. Spitznagel, Yu Du, Paul K. Peprah, Yasmeen K. Mohamed, C. David Weaver, Kyle A. Emmitte
Publikováno v:
Molecules, Vol 29, Iss 11, p 2437 (2024)
Gain-of-function mutations in the KCNT1 gene, which encodes the sodium-activated potassium channel known as SLACK, are associated with the rare but devastating developmental and epileptic encephalopathy known as epilepsy of infancy with migrating foc
Externí odkaz:
https://doaj.org/article/0f2c5566b05b4d4bb6e0881d09280aae
Autor:
Máté Katona, Ádám Bartók, Zuzana Nichtova, György Csordás, Elena Berezhnaya, David Weaver, Arijita Ghosh, Péter Várnai, David I. Yule, György Hajnóczky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The formation and dissolution of ER-Mitochondria contacts is unclear. Here, authors show that the IP3 receptor traffics in and out of the contacts and, when trapped, improves calcium signaling to stimulate energy metabolism.
Externí odkaz:
https://doaj.org/article/89e82e0994884eee859938e0f2c594f8
Autor:
Aniko Gal, Peter Balicza, David Weaver, Shamim Naghdi, Suresh K Joseph, Péter Várnai, Tibor Gyuris, Attila Horváth, Laszlo Nagy, Erin L Seifert, Maria Judit Molnar, György Hajnóczky
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-2 (2023)
Graphical Abstract
Externí odkaz:
https://doaj.org/article/05870890e3114cd0a1ae734c6b71f1e0
Autor:
Simon Timbrell, Hosam Aglan, Angela Cramer, Phil Foden, David Weaver, Jonathan Pachter, Aoife Kilgallon, Robert B. Clarke, Gillian Farnie, Nigel J. Bundred
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Cancer stem-like cells (CSC) contribute to therapy resistance and recurrence. Focal adhesion kinase (FAK) has a role in CSC regulation. We determined the effect of FAK inhibition on breast CSC activity alone and in combination with adjuvant
Externí odkaz:
https://doaj.org/article/0042b7fcefc749e8a9c051f9adcd6bb2
Autor:
Francis J. Prael III, Kwangho Kim, Yu Du, Brittany D. Spitznagel, Gary A. Sulikowski, Eric Delpire, C. David Weaver
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, a
Externí odkaz:
https://doaj.org/article/494279392eab412885fe7d235f350b87
Autor:
Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, György Hajnóczky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural
Externí odkaz:
https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b