Zobrazeno 1 - 10
of 676
pro vyhledávání: '"A. DOUGLAS KINGHORN"'
Autor:
Janet L. Oblinger, Jack Wang, Georgia D. Wetherell, Garima Agarwal, Tyler A. Wilson, Nicole R. Benson, Joelle M. Fenger, James R. Fuchs, A. Douglas Kinghorn, Long-Sheng Chang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Inhibition of translation initiation using eIF4A inhibitors like (−)-didesmethylrocaglamide [(−)-DDR] and (−)-rocaglamide [(−)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers.
Externí odkaz:
https://doaj.org/article/9f51765470304068adff9d89398af258
Autor:
Banaz Jalil, Judith M. Rollinger, Atanas G. Atanasov, Rajeev K. Singla, A. Douglas Kinghorn, Michael Heinrich
Publikováno v:
Frontiers in Natural Products, Vol 3 (2024)
Natural products have long been a cornerstone of drug discovery, providing diverse and biologically relevant chemical scaffolds. This work aims to guide newcomers to natural product research and, specifically, drug discovery by presenting a curated l
Externí odkaz:
https://doaj.org/article/efbbf7a762b047fe8337dd15b5ef43d3
Autor:
Peter J. Blanco Carcache, Ines Y. Castro-Dionicio, Nathan P. Mirtallo Ezzone, Eric D. Salinas-Arrellano, Joshua Bahar, Steven K. Clinton, A. Douglas Kinghorn
Publikováno v:
Molecules, Vol 29, Iss 20, p 4919 (2024)
Currently, clinically available cancer chemopreventive drug options are limited to mostly tamoxifen and its derivatives, such as raloxifene, and approved specifically for breast cancer. Thus, the availability of chemopreventive drug molecules for oth
Externí odkaz:
https://doaj.org/article/8fc3ad2a6b26454587d1fd5af3bf42b2
Autor:
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer
Externí odkaz:
https://doaj.org/article/e4c4de122bed46cdace434fd84397a5c
Autor:
Yulin Ren, Tyler Frank, Gunnar Meyer, Jizhou Lei, Jessica R. Grebenc, Ryan Slaughter, Yu G. Gao, A. Douglas Kinghorn
Publikováno v:
Molecules, Vol 27, Iss 22, p 7823 (2022)
Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show mult
Externí odkaz:
https://doaj.org/article/2a99af01c46643d09093058cbd09e49a
Autor:
Anusha Amaravathi, Janet L. Oblinger, D. Bradley Welling, A. Douglas Kinghorn, Long-Sheng Chang
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The neurofibromatosis syndromes, including NF1, NF2, and schwannomatosis, are tumor suppressor syndromes characterized by multiple nervous system tumors, particularly Schwann cell neoplasms. NF-related tumors are mainly treated by surgery, and some o
Externí odkaz:
https://doaj.org/article/3619a9d037e049dcbaa7938cfc6cce89
Autor:
P. Annécie Benatrehina, Wei-Lun Chen, Austin A. Czarnecki, Steven Kurina, Hee-Byung Chai, Daniel D. Lantvit, Tran N. Ninh, Xiaoli Zhang, Djaja D. Soejarto, Joanna E. Burdette, A. Douglas Kinghorn, L. Harinantenaina Rakotondraibe
Publikováno v:
Natural Products and Bioprospecting, Vol 9, Iss 2, Pp 157-163 (2019)
Abstract Bioactivity-guided phytochemical investigation of Podocarpus neriifolius D. Don. (Podocarpaceae) has led to the isolation of one new (2) and three known (1, 3, and 4) B-type podolactones, along with three totarane-type diterpenes (5-7). Thei
Externí odkaz:
https://doaj.org/article/5f74bd6b2584474a920d998bfad0a41e
Autor:
Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, Jason M. Rohde
Publikováno v:
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
Externí odkaz:
https://doaj.org/article/9f2975f36dd648f0b92b6e0f2b27c087
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 8, Iss 2, Pp 267-277 (2018)
In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected
Externí odkaz:
https://doaj.org/article/02154e1f39aa4207a8af710e69e8b2a8
Publikováno v:
Molecules, Vol 26, Iss 18, p 5675 (2021)
Docking profiles for (+)-strebloside, a cytotoxic cardiac glycoside identified from Streblus asper, and some of its derivatives and Na+/K+-ATPase have been investigated. In addition, binding between (+)-strebloside and its aglycone, strophanthidin, a
Externí odkaz:
https://doaj.org/article/62f52fe9a7ce47869aec3223c161fa8b