Zobrazeno 1 - 10
of 41
pro vyhledávání: '"A. D. Sauerbeck"'
Autor:
A. R. Blissett, B. Deng, P. Wei, K. J. Walsh, B. Ollander, J. Sifford, A. D. Sauerbeck, D. W. McComb, D. M. McTigue, G. Agarwal
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Iron (Fe) is an essential metal involved in a wide spectrum of physiological functions. Sub-cellular characterization of the size, composition, and distribution of ferritin(iron) can provide valuable information on iron storage and transport
Externí odkaz:
https://doaj.org/article/6359350fef4441e7bfe739a45e49aaf9
Autor:
Jit Chatterjee, Joshua P. Koleske, Astoria Chao, Andrew D. Sauerbeck, Ji-Kang Chen, Xuanhe Qi, Megan Ouyang, Lucy G. Boggs, Rujuta Idate, Lara Isabel Marco Y Marquez, Terrence T. Kummer, David H. Gutmann
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Tissue injury and tumorigenesis share many cellular and molecular features, including immune cell (T cells, monocytes) infiltration and inflammatory factor (cytokines, chemokines) elaboration. Their common pathobiology raises the intriguing
Externí odkaz:
https://doaj.org/article/e13718c6e74748998e03e14aae30335c
Autor:
Hsin-Chieh Yang, Raj Swaroop Lavadi, Andrew D. Sauerbeck, Michael Wallendorf, Terrance T. Kummer, Sheng-Kwei Song, Tsen-Hsuan Lin
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionTraumatic optic neuropathy (TON) is the optic nerve injury secondary to brain trauma leading to visual impairment and vision loss. Current clinical visual function assessments often fail to detect TON due to slow disease progression and c
Externí odkaz:
https://doaj.org/article/1d481866b3074b6487f1f9dd1888781e
Autor:
Sidney B. Williams, Andrew D. Sauerbeck, Christopher R. Trousdale, Min-Yu Sun, Alexis N. Harris, Joseph D. Dougherty, Elliot C. Nelson, Jose A. Morón, Hannah E. Frye, Yukitoshi Izumi, Terrance T. Kummer, Steven Mennerick, Charles F. Zorumski
Publikováno v:
Biological Psychiatry. 90:766-780
Background CNIH3 is an AMPA receptor (AMPAR) auxiliary protein prominently expressed in the dorsal hippocampus (dHPC), a region that plays a critical role in spatial memory and synaptic plasticity. However, the effects of CNIH3 on AMPAR-dependent syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc70e564f53c68c09a6c1a100a6bce7
https://doi.org/10.1016/j.biopsych.2021.07.014
https://doi.org/10.1016/j.biopsych.2021.07.014
Autor:
Anthony N. Alfredo, Evan Z. Goldstein, Andrew D. Sauerbeck, Dana M. McTigue, Alexander Marcillo, Michael D. Norenberg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Synucleinopathies are neurodegenerative diseases in which α-synuclein protein accumulates in neurons and glia. In these diseases, α-synuclein forms dense intracellular aggregates that are disease hallmarks and actively contribute to tissue patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d653ac6fe2633a5e9b805e372a1d793
https://doaj.org/article/9a2dff3f6e0e49ada4d12e2e9197b909
https://doaj.org/article/9a2dff3f6e0e49ada4d12e2e9197b909
Autor:
Marie-Ève Tremblay, Cheryl E. G. Leyns, Jason D. Ulrich, Terrance T. Kummer, Marco Colonna, Monica Xiong, Andrew D. Sauerbeck, Nayeon Kim, Marie-Kim St-Pierre, Javier Remolina Serrano, David M. Holtzman, Maud Gratuze
Publikováno v:
J Clin Invest
Alzheimer’s disease (AD) is characterized by plaques containing amyloid-β (Aβ) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau and Aβ, evidence suggests that microglia play an important role in AD pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52e7e54cc21f9243a85c9a13ef81f5c
https://doi.org/10.1172/jci138179
https://doi.org/10.1172/jci138179
Publikováno v:
Curr Protoc
Immunofluorescence labeling and microscopy offer a highly specific means to visualize proteins or other molecular species in a sample by labeling target antigens with fluorescent probes. These fluorescent probes can then be visualized using a fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccb5d115f18dd674efb9af551559321
https://pubmed.ncbi.nlm.nih.gov/34387945
https://pubmed.ncbi.nlm.nih.gov/34387945
Autor:
Chiseko Ikenaga, Jiang Zhu, Abdallah M. Eteleeb, Rolf Schröder, Andrew D. Sauerbeck, Carla M. Yuede, Jason D. Ulrich, Sara K. Pittman, Conrad C. Weihl, Khalid Arhzaouy, Feng Wang, Sydney J. Reitz, Oscar Harari, Terrance T. Kummer, Christoph S. Clemen, Abubakar Wani, Shan Li, Bruno A. Benitez, Carlos Cruchaga, Tsui-Fen Chou
Publikováno v:
Cell reports
SUMMARY The pathogenic mechanism by which dominant mutations in VCP cause multisystem proteinopathy (MSP), a rare neurodegenerative disease that presents as fronto-temporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), remains unclear. To exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16965f9cc536d611d8be1b4d52b3c971
https://resolver.caltech.edu/CaltechAUTHORS:20210811-212815828
https://resolver.caltech.edu/CaltechAUTHORS:20210811-212815828
Autor:
Kathleen M, Schoch, Lubov A, Ezerskiy, Michaela M, Morhaus, Riley N, Bannon, Andrew D, Sauerbeck, Mark, Shabsovich, Paymaan, Jafar-Nejad, Frank, Rigo, Timothy M, Miller
Publikováno v:
Proc Natl Acad Sci U S A
Heterozygous genetic variants within the TREM2 gene show a strong association with increased Alzheimer’s disease (AD) risk. Amyloid beta–depositing mouse models haploinsufficient or null for Trem2 have identified important relationships among TRE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0184e0d545ba34557416ee0311389acd
https://pubmed.ncbi.nlm.nih.gov/34187891
https://pubmed.ncbi.nlm.nih.gov/34187891
Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice
Autor:
Timothy M. Miller, Michaela M Morhaus, Mark Shabsovich, Paymaan Jafar-Nejad, Frank Rigo, Lubov Ezerskiy, Kathleen M. Schoch, Riley N Bannon, Andrew D. Sauerbeck
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Heterozygous genetic variants within the TREM2 gene show a strong association with increased Alzheimer's disease (AD) risk. Amyloid beta-depositing mouse models haploinsufficient or null for Trem2 have identified important relationships among TREM2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9997bcd52a8070b003b9cfcd56eeeefe
https://doi.org/10.1073/pnas.2100356118
https://doi.org/10.1073/pnas.2100356118