Zobrazeno 1 - 10
of 550
pro vyhledávání: '"A. D. Roses"'
Autor:
Lei Yu, Michael W Lutz, Robert S Wilson, Daniel K Burns, Allen D Roses, Ann M Saunders, Jingyun Yang, Chris Gaiteri, Philip L De Jager, Lisa L Barnes, David A Bennett
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180356 (2017)
Patterns of linkage between the ε4 allele of Apolipoprotein E (APOE) and '523 poly-T alleles in the adjacent gene, TOMM40, differ between Caucasian and African Americans. The extent to which this difference affects the risk of Alzheimer's disease (A
Externí odkaz:
https://doaj.org/article/9346f1093cb546f99d3b8a84822231a2
Autor:
Donna G Crenshaw, Karen Asin, William K Gottschalk, Zhifeng Liang, Nanyin Zhang, Allen D Roses
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117973 (2015)
Pioglitazone (PIO) is a peroxisome proliferator-activated receptor-γ (PPARγ) agonist in clinical use for treatment of type 2 diabetes (T2DM). Accumulating evidence suggests PPARγ agonists may be useful for treating or delaying the onset of Alzheim
Externí odkaz:
https://doaj.org/article/9aaf4b2f7c714db48c6f20e660bb490a
Publikováno v:
Neurobiology of Disease, Vol 13, Iss 3, Pp 273-282 (2003)
Alzheimer’s disease (AD) is associated with genetic risk factors, of which the allele E4 of apolipoprotein E (apoE4) is the most prevalent, and is affected by environmental factors that include education early in life and socioeconomic background.
Externí odkaz:
https://doaj.org/article/ed56fc2b571441d7904ea938e9a51de9
Autor:
Pu-Ting Xu, Donald Schmechel, Hui-Ling Qiu, Michael Herbstreith, Tracie Rothrock-Christian, Michele Eyster, Allen D. Roses, John R. Gilbert
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 1, Pp 63-75 (1999)
Mice transgenic for human APOE2, E3, and E4 alleles express native 34-kDa human apoE and two sialylated apoE isoproteins with approximate molecular weights of 37 kDa (apoEs) and 39 kDa (apoEs2) in brain. These multiple apoE/apoEs/apoEs2band patterns
Externí odkaz:
https://doaj.org/article/720c48fe221140a1b1a7c8646293ffab
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 4, Pp 271-279 (1998)
Apolipoprotein E (apoE) has been confirmed as a risk factor for late-onset Alzheimer's disease (AD) and is associated with neurofibrillary tangles and senile plaques, the microscopic pathological characteristics of AD. There has been no direct eviden
Externí odkaz:
https://doaj.org/article/1f7e09a23ea44a2da71a8936ba4be5c1
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 1, Pp 58-67 (1997)
Apolipoprotein E has been shown to be a risk factor for late-onset Alzheimer's disease, with the apolipoprotein ϵ4 allele conferring the risk. Apolipoprotein E is found in neurofibrillary tangles and senile plaques, the pathological characteristics
Externí odkaz:
https://doaj.org/article/05bb47afffaa46d38653568922122083
Autor:
Allen D. Roses
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 3, Pp 170-185 (1997)
Age-dependent neurodegeneration in Alzheimer disease (AD) may be viewed as a complex interaction among: (i) susceptibility polymorphisms, (ii) somatic mutations or alterations that occur over extended periods of time, and (iii) environmental interact
Externí odkaz:
https://doaj.org/article/ee0c9a80d9d146f79ec7e59841e8aaa8
Autor:
Donald M Lyall, Natalie A Royle, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria C del Valdés Hernández, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Deary
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80513 (2013)
The APOE ε and TOMM40 rs10524523 ('523') variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer's disease (AD) related phenotypes such as age of clinical onset. Hippocampal atrophy has been signif
Externí odkaz:
https://doaj.org/article/4b656b486d5a421890436bac0f1814b1
Autor:
Julia, Pytte, Loren L, Flynn, Ryan S, Anderton, Frank L, Mastaglia, Frances, Theunissen, Ian, James, Abigail, Pfaff, Sulev, Koks, Ann M, Saunders, Richard, Bedlack, Daniel K, Burns, Michael W, Lutz, Nailah, Siddique, Teepu, Siddique, Allen D, Roses, P Anthony, Akkari
Publikováno v:
Neurology: Genetics
Objective To test the hypothesis that rs573116164 will have disease-modifying effects in patients with superoxide dismutase 1 (SOD1) familial amyotrophic lateral sclerosis (fALS), we characterized rs573116164 within a cohort of 190 patients with fALS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6245882d6421c1f92beca146f2c882ab
https://pubmed.ncbi.nlm.nih.gov/32754644
https://pubmed.ncbi.nlm.nih.gov/32754644
Publikováno v:
Proceedings - ettc2020.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59c88d4cda5020087e118ef5c97faad
https://doi.org/10.5162/ettc2020/6.7
https://doi.org/10.5162/ettc2020/6.7