Zobrazeno 1 - 10
of 15
pro vyhledávání: '"A. D. Piekarz"'
Publikováno v:
Tribologia. 282:11-15
The article presents the results of friction coefficient measurements of selected polymer materials applied for elements of winter sports equipmentsliding against ice. After testing, one of thematerials, polyethylene, which is the most commonly used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c49556b815d6b057a554aa6a511592c
https://doi.org/10.5604/01.3001.0012.8412
https://doi.org/10.5604/01.3001.0012.8412
Autor:
Andrew D. Piekarz, Daniel Ursu, Antoine Fouillet, Xiaofang Huang, Jake F. Watson, Baolin Li, Birgit T. Priest, Eric S. Nisenbaum, Emanuele Sher
Publikováno v:
Molecular Pain
Background The Nav1.7 subtype of voltage-gated sodium channels is specifically expressed in sensory and sympathetic ganglia neurons where it plays an important role in the generation and transmission of information related to pain sensation. Human lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2ce0228231c1774da43eecd46b91a6
https://pubmed.ncbi.nlm.nih.gov/29166836
https://pubmed.ncbi.nlm.nih.gov/29166836
Autor:
Q. Xu, Tony L. Yaksh, William A. Eckert, Michael J. Hunter, Rebecca Hagan, J. Freedman, M. Zhou, A. D. Piekarz, Ross Fellows, Rachelle Bonesteel, Kelly A. Eddinger, Michael W. Pennington, Alan Gibbs, Yanfang Liu, Alan D. Wickenden, Ronald V. Swanson, Robert A. Neff, Mack Flinspach
Publikováno v:
Scientific Reports
Scientific reports, vol 7, iss 1
Scientific reports, vol 7, iss 1
Pain places a devastating burden on patients and society and current pain therapeutics exhibit limitations in efficacy, unwanted side effects and the potential for drug abuse and diversion. Although genetic evidence has clearly demonstrated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d007efa4fb9267ccd4fec38368d0f7cc
https://doi.org/10.1038/srep39662
https://doi.org/10.1038/srep39662
Autor:
Hanying Chen, Peilin Ma, Andy Hudmon, Andrew D. Piekarz, Weihua Song, Nicole M. Ashpole, Theodore R. Cummins, Yucheng Xiao, Weinian Shou
Publikováno v:
The Journal of Physiology. 590:5123-5139
Key points • We investigated how the F1486 deletion LQT3 mutation impairs the functional properties of the human cardiac voltage-gated sodium channel (hNav1.5) and alters action potential firing. • Voltage-clamp recordings from HEK 293 cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b284d79f71117dd64dfc02257512471
https://doi.org/10.1113/jphysiol.2012.235374
https://doi.org/10.1113/jphysiol.2012.235374
Autor:
May Khanna, Rajesh Khanna, Sarah M. Wilson, Matthew S. Ripsch, Nathan M. Hammes, Brian C Samuels, Joyce H. Hurley, Fletcher A. White, Carrie J. Ballard, Theodore R. Cummins, Joel M. Brittain, Andrew D. Piekarz
Publikováno v:
Channels. 5:449-456
The N-type voltage-gated calcium channel (Cav 2.2) has gained immense prominence in the treatment of chronic pain. While decreased channel function is ultimately anti-nociceptive, directly targeting the channel can lead to multiple adverse side effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b81cf39c58ac4afd7a5575bbcd87f78
https://doi.org/10.4161/chan.5.5.17363
https://doi.org/10.4161/chan.5.5.17363
Publikováno v:
The Journal of Physiology. 589:597-608
Abnormal pain sensitivity associated with inherited and acquired pain disorders occurs through increased excitability of peripheral sensory neurons in part due to changes in the properties of voltage-gated sodium channels (Navs). Resurgent sodium cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b66118eaf61445e89ca2fbee66d42f6
https://doi.org/10.1113/jphysiol.2010.200915
https://doi.org/10.1113/jphysiol.2010.200915
Publikováno v:
Journal of Clinical Investigation. 120:369-378
Inherited mutations in voltage-gated sodium channels (VGSCs; or Nav) cause many disorders of excitability, including epilepsy, chronic pain, myotonia, and cardiac arrhythmias. Understanding the functional consequences of the disease-causing mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f222e15c2c1f7ad5321e04d623ea2858
https://doi.org/10.1172/jci40801
https://doi.org/10.1172/jci40801
Autor:
Theodore R. Cummins, Birgit T. Priest, Jeff S. McDermott, Eric S. Nisenbaum, Jeffrey L. Krajewski, Kelly L. Knopp, Andrew D. Piekarz, Zhi Yong Tan
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(21)
Resurgent sodium currents contribute to the regeneration of action potentials and enhanced neuronal excitability. Tetrodotoxin-sensitive (TTX-S) resurgent currents have been described in many different neuron populations, including cerebellar and dor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9205a6ddc4bc23d7d3395ca6386583
https://pubmed.ncbi.nlm.nih.gov/24849353
https://pubmed.ncbi.nlm.nih.gov/24849353
Autor:
Xiao Fang Yang, Yuying Wang, Christophe Salomé, Erik T. Dustrude, Cindy Barbosa, Harold Kohn, Sarah M. Wilson, Fletcher A. White, Michael R. Due, Rajesh Khanna, Andrew D. Piekarz, Theodore R. Cummins, Amber M. King
Publikováno v:
ACS chemical neuroscience. 3(12)
Four compounds that contained the N-benzyl 2-amino-3-methoxypropionamide unit were evaluated for their ability to modulate Na(+) currents in catecholamine A differentiated CAD neuronal cells. The compounds differed by the absence or presence of eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d34805321bdd480b386fb72368cbf
https://pubmed.ncbi.nlm.nih.gov/23259039
https://pubmed.ncbi.nlm.nih.gov/23259039
Publikováno v:
The Journal of physiology. 589(Pt 3)
Abnormal pain sensitivity associated with inherited and acquired pain disorders occurs through increased excitability of peripheral sensory neurons in part due to changes in the properties of voltage-gated sodium channels (Navs). Resurgent sodium cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::605fad66c27b461b5fe7d767a065c7a0
https://pubmed.ncbi.nlm.nih.gov/21486843
https://pubmed.ncbi.nlm.nih.gov/21486843