Zobrazeno 1 - 8
of 8
pro vyhledávání: '"A. D. J. Scadden"'
Publikováno v:
Nucleic Acids Research
Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up to 50% of adenosine residues may be converted to inosine. However, although numerous RNAs may undergo hyper-editing, the role for inosine-con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10344fdc5da2a8e44773325f8c12dc80
http://europepmc.org/articles/PMC3834823
http://europepmc.org/articles/PMC3834823
Autor:
Robert Young, A. D. J. Scadden, Paul J. McLaughlin, Sam M. Greenwood, Ian R. Adams, Cornelia Vesely, Julia R. Dorin, James Brindle, Liam Keegan, Chris P. Ponting, Marie Öhman, Christoffer Nellåker, Niamh M. Mannion, David Read, Mary A O'Connell, Sarah L. Cox, Michael F. Jantsch
Publikováno v:
Cell Reports
Mannion, N M, Greenwood, S M, Young, R, Cox, S, Brindle, J, Read, D, Nellåker, C, Vesely, C, Ponting, C P, McLaughlin, P J, Jantsch, M F, Dorin, J, Adams, I R, Scadden, A D J, Öhman, M, Keegan, L P & O'Connell, M A 2014, ' The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA ', Cell Reports, vol. 9, no. 4, pp. 1482-1494 . https://doi.org/10.1016/j.celrep.2014.10.041
Cell Reports, Vol 9, Iss 4, Pp 1482-1494 (2014)
Mannion, N M, Greenwood, S M, Young, R, Cox, S, Brindle, J, Read, D, Nellåker, C, Vesely, C, Ponting, C P, McLaughlin, P J, Jantsch, M F, Dorin, J, Adams, I R, Scadden, A D J, Öhman, M, Keegan, L P & O'Connell, M A 2014, ' The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA ', Cell Reports, vol. 9, no. 4, pp. 1482-1494 . https://doi.org/10.1016/j.celrep.2014.10.041
Cell Reports, Vol 9, Iss 4, Pp 1482-1494 (2014)
Summary The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44cd1c0007b8a965262c548ecf260d2
https://ora.ox.ac.uk/objects/uuid:c2cd1727-8af2-4b46-b893-ed7a80d13428
https://ora.ox.ac.uk/objects/uuid:c2cd1727-8af2-4b46-b893-ed7a80d13428
Autor:
Rebekka Weissbach, A. D. J. Scadden
Publikováno v:
RNA. 18:462-471
Hyperediting by adenosine deaminases that acts on RNA (ADARs) may result in numerous Adenosine-to-Inosine (A-to-I) substitutions within long dsRNA. However, while countless RNAs may undergo hyperediting, the role for inosine-containing hyperedited ds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94896a171c0b382c0f224b323c0d208a
https://doi.org/10.1261/rna.027656.111
https://doi.org/10.1261/rna.027656.111
Autor:
Patrice Vitali, A. D. J. Scadden
Publikováno v:
Nature Structural & Molecular Biology. 17:1043-1050
Adenosine deaminases acting on RNA (ADARs) catalyze hyperediting of long double-stranded RNAs (dsRNAs), whereby up to 50% of adenosines are converted to inosine (I). Although hyperedited dsRNAs (IU-dsRNAs) have been implicated in various cellular fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c003e0a15f99f5f0a604a9bb6f3c44cd
https://doi.org/10.1038/nsmb.1864
https://doi.org/10.1038/nsmb.1864
Publikováno v:
EMBO reports. 2:1107-1111
RNA interference (RNAi) and adenosine to inosine conversion are both mechanisms that respond to double-stranded RNA (dsRNA) and have been suggested to have antiviral roles. RNAi involves processing of dsRNA to short interfering RNAs (siRNAs), which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b897cfe2d917cbae15d25f10e60c80de
https://doi.org/10.1093/embo-reports/kve244
https://doi.org/10.1093/embo-reports/kve244
Publikováno v:
The EMBO Journal. 20:4243-4252
Extended double-stranded DNA (dsRNA) duplexes can be hyper-edited by adenosine deaminases that act on RNA (ADARs). Long uninterrupted dsRNA is relatively uncommon in cells, and is frequently associated with infection by DNA or RNA viruses. Moreover,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b5d18f8d689bcb588c3f94ab64f0ca
https://doi.org/10.1093/emboj/20.15.4243
https://doi.org/10.1093/emboj/20.15.4243
Publikováno v:
The EMBO Journal. 16:2140-2149
RNA transcripts in which all guanosine residues are replaced by inosine are degraded at a highly accelerated rate when incubated in extracts from HeLa cells, sheep uterus or pig brain. We report here the partial purification and characterization of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574247584588703444a1c48067fb27d
https://doi.org/10.1093/emboj/16.8.2140
https://doi.org/10.1093/emboj/16.8.2140
Autor:
A. D. J. Scadden, Justine Southby, Clare Gooding, Alexis P Rideau, Robert H. Singer, Stefan Hüttelmaier, Christopher W.J. Smith, Natalia Gromak
Publikováno v:
The EMBO journal. 22(23)
Regulated switching of the mutually exclusive exons 2 and 3 of alpha-tropomyosin (TM) involves repression of exon 3 in smooth muscle cells. Polypyrimidine tract-binding protein (PTB) is necessary but not sufficient for regulation of TM splicing. Rave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437b3262e6e61b1da6a3d2c1e8bcaf0a
http://ora.ox.ac.uk/objects/uuid:b70ebd3f-7d51-4332-93cc-2da2781ac60b
http://ora.ox.ac.uk/objects/uuid:b70ebd3f-7d51-4332-93cc-2da2781ac60b