Zobrazeno 1 - 10
of 1 835
pro vyhledávání: '"A. D. Costa"'
Autor:
Dharmender K. Gahlot, Jonasz B. Patkowski, Jaime Fernández de Santaella, Luke P. Allsopp, Zhiqiao Pan, Alain Filloux, Gerald Larrouy-Maumus, Matthew S. Francis, Tiago R. D. Costa
Publikováno v:
npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-13 (2024)
Abstract Antibiotic resistance is a global healthcare crisis. Bacteria are highly adaptable and can rapidly acquire mechanisms of resistance towards conventional antibiotics. The permeability barrier conferred by the Gram-negative bacteria cell envel
Externí odkaz:
https://doaj.org/article/f0b61af3446e4035a64931c15aebcdd5
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Modulation of the Nrf2 pathway, a master regulator of the antioxidant response and cellular metabolism, has been suggested as a promising therapeutic strategy in tauopathies, a heterogeneous group of neurodegenerative disorders characterized
Externí odkaz:
https://doaj.org/article/8b9f4e374bc34b5c96693057c8ff5a17
Autor:
Lingchen He, Laura Miguel-Romero, Jonasz B. Patkowski, Nasser Alqurainy, Eduardo P. C. Rocha, Tiago R. D. Costa, Alfred Fillol-Salom, José R. Penadés
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Many bacterial immune systems recognize phage structural components to activate antiviral responses, without inhibiting the function of the phage component. These systems can be encoded in specific chromosomal loci, known as defense islands,
Externí odkaz:
https://doaj.org/article/b98ef47ae13041da90e6cd058eed4d51
Autor:
Reza Aghavali, Erin G. Roberts, Yosuke K. Kurokawa, Erica Mak, Martin Y.C. Chan, Andy O.T. Wong, Ronald A. Li, Kevin D. Costa
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107459- (2024)
Cardiac screening of newly discovered drugs remains a longstanding challenge for the pharmaceutical industry. While therapeutic efficacy and cardiotoxicity are evaluated through preclinical biochemical and animal testing, 90 % of lead compounds fail
Externí odkaz:
https://doaj.org/article/7fb2a039a28d455ab39a5bb2f8faee3b
Publikováno v:
Hydrology and Earth System Sciences, Vol 28, Pp 2785-2807 (2024)
Systematic tile drainage is used extensively in poorly drained agricultural lands to remove excess water and improve crop growth; however, tiles can also transfer nutrients from farmlands to downstream surface water bodies, leading to water quality p
Externí odkaz:
https://doaj.org/article/5f22a8fec2bd4507972b59c5289589e1
Autor:
Selina Fecht, Patricia Paracuellos, Sujatha Subramoni, Casandra Ai Zhu Tan, Aravindan Ilangovan, Tiago R. D. Costa, Alain Filloux
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The genome of Pseudomonas aeruginosa encodes three type VI secretion systems, each comprising a dozen distinct proteins, which deliver toxins upon T6SS sheath contraction. The least conserved T6SS component, TssA, has variations in size whic
Externí odkaz:
https://doaj.org/article/3abfa31a14b442cfb7b894626719e8d1
Autor:
Danielle N. D’Erminio, Kaya A. Adelzadeh, Ashley M. Rosenberg, Robert J. Wiener, Olivia M. Torre, Emily D. Ferreri, Philip Nasser, Kevin D. Costa, Woojin M. Han, Alice H. Huang, James C. Iatridis
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110883- (2024)
Summary: Intervertebral disc (IVD) defects heal poorly and can cause back pain and disability. We identified that IVD herniation injury heals regeneratively in neonatal mice until postnatal day 14 (p14) and shifts to fibrotic healing by p28. This age
Externí odkaz:
https://doaj.org/article/ee8939875d934d66b1c0389ff1beea90
Autor:
Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of 24-month-old mice rejuvenates cardiac function and substantially
Externí odkaz:
https://doaj.org/article/b0477fcf8cac487d9b9bce149837c365
Autor:
Yatendra Shukla, Ponraj Kamatchi Sundaram, Jinendra Kumar Ramalingam, Jorson D. Costa, Amey Parab, Subhash Jakhar, Ganesh Chauhan, Rohit Bharti
Publikováno v:
Indian Journal of Neurosurgery, Vol 13, Iss 01, Pp 027-034 (2024)
Objective Decompressive craniectomy (DC) is an urgent procedure which is done to decrease intracranial pressure. A study of the complications would suggest measures to improve the care. This study was focused on analyzing the complications after cran
Externí odkaz:
https://doaj.org/article/e2ab36529cd34e208ea8261614663a4a
Autor:
Praveen Suthaharan, Summer L. Thompson, Rosa A. Rossi-Goldthorpe, Peter H. Rudebeck, Mark E. Walton, Subhojit Chakraborty, Maryann P. Noonan, Vincent D. Costa, Elisabeth A. Murray, Christoph D. Mathys, Stephanie M. Groman, Anna S. Mitchell, Jane R. Taylor, Philip R. Corlett, Steve W.C. Chang
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114355- (2024)
Summary: Beliefs—attitudes toward some state of the environment—guide action selection and should be robust to variability but sensitive to meaningful change. Beliefs about volatility (expectation of change) are associated with paranoia in humans
Externí odkaz:
https://doaj.org/article/52aae4e6dde04269b1b861c5307d2e76