Zobrazeno 1 - 10
of 452
pro vyhledávání: '"A. D. Cherrington"'
Autor:
Elizabeth B. Quigley, Stanley B. DeVore, Shaihla A. Khan, Zachary M. Geisterfer, Heather M. Rothfuss, Ari O. Sequoia, Paul R. Thompson, Jesse C. Gatlin, Brian D. Cherrington, Amy M. Navratil
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3181 (2024)
Peptidylarginine deiminases (PADs or PADIs) catalyze the conversion of positively charged arginine to neutral citrulline, which alters target protein structure and function. Our previous work established that gonadotropin-releasing hormone agonist (G
Externí odkaz:
https://doaj.org/article/37a1b90d74a74f81a3ff66e91b120a8a
Autor:
Justin M Gregory, Guillaume Kraft, Chiara Dalla Man, James C Slaughter, Melanie F Scott, Jon R Hastings, Dale S Edgerton, Mary C Moore, Alan D Cherrington
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0296400 (2023)
This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also triggered m
Externí odkaz:
https://doaj.org/article/b4efcee09ef24e3d9b97e56324454927
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.
Externí odkaz:
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Mary Courtney Moore, Shana O. Warner, Yufei Dai, Nicole Sheanon, Marta Smith, Ben Farmer, Rebecca L. Cason, Alan D. Cherrington, Jason J. Winnick
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Several studies have associated the presence of residual insulin secretion capability (also referred to as being C-peptide positive) with lower risk of insulin-induced hypoglycemia in patients with type 1 diabetes (T1D), although the reason is unclea
Externí odkaz:
https://doaj.org/article/4b727d6ed3e1483b89dd8f0b32fffe24
Autor:
Dale S. Edgerton, Guillaume Kraft, Marta Smith, Ben Farmer, Phillip Williams, Alan D. Cherrington
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E199-E208
Glucagon stimulates hepatic glucose production through its direct effects on the liver but may indirectly inhibit this process by acting on the brain. This was tested by delivering glucagon via the cerebral circulatory system. Central nervous system
Autor:
Guillaume Kraft, Melanie Scott, Eric Allen, Dale S. Edgerton, Ben Farmer, Bobak R. Azamian, Alan D. Cherrington
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract The objective of this study was to assess the safety of surgical common hepatic artery denervation (CHADN). This procedure has previously been shown to improve glucose tolerance in dogs fed a high‐fat high‐fructose (HFHF) diet. We assess
Externí odkaz:
https://doaj.org/article/17b766eb1f7f4c01b67f37624d503b8e
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Gonadotropes cells located in the anterior pituitary gland are critical for reproductive fitness. A rapid surge in the serum concentration of luteinizing hormone (LH) secreted by anterior pituitary gonadotropes is essential for stimulating ovulation
Externí odkaz:
https://doaj.org/article/984c5a01c96548439d6b7bb3d6542768
Autor:
Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Jon Hastings, Alan D. Cherrington, Dale S. Edgerton
Publikováno v:
Diabetes. 72:196-209
Endogenous insulin secretion is a key regulator of postprandial hepatic glucose metabolism, but this process is dysregulated in diabetes. Subcutaneous insulin delivery alters normal insulin distribution, causing relative hepatic insulin deficiency an
Publikováno v:
Journal of Diabetes Science and Technology. 16:1567-1574
Modern changes in diet and lifestyle have led to an explosion of insulin resistance and metabolic diseases around the globe which, if left unchecked, will become a principal driver of morbidity and mortality in the 21st century. The nature of the met
Autor:
Harold E Lebovitz, Alexander Fleming, Alan D Cherrington, Shashank Joshi, Sandeep N Athalye, Subramanian Loganathan, Ashwini Vishweswaramurthy, Jayanti Panda, Ashwani Marwah
Publikováno v:
Expert opinion on pharmacotherapy. 23(16)
Efficacy and safety of ultra-rapid acting oral prandial insulin Tregopil was compared with insulin aspart (IAsp) in patients with type 2 diabetes (T2D) on insulin glargine and metformin. In this open-label, active-controlled trial, patients with T2D,