Zobrazeno 1 - 10
of 160
pro vyhledávání: '"A. D. Bershadsky"'
Autor:
N. O. Alieva, A. K. Efremov, S. Hu, D. Oh, Z. Chen, M. Natarajan, H. T. Ong, A. Jégou, G. Romet-Lemonne, J. T. Groves, M. P. Sheetz, J. Yan, A. D. Bershadsky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and form
Externí odkaz:
https://doaj.org/article/239c9ca67f0f454d9d9ef6109dc7854c
Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives
Autor:
Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F. H. Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D. Bershadsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
In this work, the authors identify regulators of actin filament assembly involved in chiral organisation of the actin cytoskeleton in single cells and chiral alignment of cells in groups. This provides insights into how actin-driven chirality underli
Externí odkaz:
https://doaj.org/article/a04bac554ea94ed8891bb4b8355d7cab
Autor:
Bipul R. Acharya, Selwin K. Wu, Zi Zhao Lieu, Robert G. Parton, Stephan W. Grill, Alexander D. Bershadsky, Guillermo A. Gomez, Alpha S. Yap
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2854-2867 (2017)
Formins are a diverse class of actin regulators that influence filament dynamics and organization. Several formins have been identified at epithelial adherens junctions, but their functional impact remains incompletely understood. Here, we tested the
Externí odkaz:
https://doaj.org/article/78266f0bc89a48699a31cb4997d97b48
Autor:
Wenhong Li, Wen-Lu Chung, Michael M. Kozlov, Ohad Medalia, Benjamin Geiger, Alexander D. Bershadsky
Adherent filopodia are elongated finger-like membrane protrusions, extending from the edges of diverse cell types and participating in cell adhesion, spreading, migration and environmental sensing. The formation and elongation of filopodia are driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5bfb2343f65de0819f17aacfa65317
https://doi.org/10.1101/2022.06.09.495577
https://doi.org/10.1101/2022.06.09.495577
Autor:
Cheng-han Yu, Nisha Bte Mohd Rafiq, Anitha Krishnasamy, Kevin L. Hartman, Gareth E. Jones, Alexander D. Bershadsky, Michael P. Sheetz
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1456-1468 (2013)
Matrix-activated integrins can form different adhesion structures. We report that nontransformed fibroblasts develop podosome-like adhesions when spread on fluid Arg-Gly-Asp peptide (RGD)-lipid surfaces, whereas they habitually form focal adhesions o
Externí odkaz:
https://doaj.org/article/a0299df790664630a4d5626619be626f
Autor:
Artem K, Efremov, Mingxi, Yao, Yuze, Sun, Yee Han, Tee, Michael P, Sheetz, Alexander D, Bershadsky, Boris, Martinac, Jie, Yan
Publikováno v:
Biomaterials. 284
Filopodia are ubiquitous membrane projections that play crucial role in guiding cell migration on rigid substrates and through extracellular matrix by utilizing yet unknown mechanosensing molecular pathways. As recent studies show that Ca
Autor:
HaiYang, Wang, Jinrong, Hu, Kexi, Yi, Zhiming, Ma, XinJie, Song, Yaelim, Lee, Petr, Kalab, Alexander D, Bershadsky, Yansong, Miao, Rong, Li
Publikováno v:
SSRN Electronic Journal.
The first asymmetric meiotic cell divisions in mouse oocytes are driven by formin 2 (FMN2)-nucleated actin polymerization around the spindle. In this study, we investigated how FMN2 is recruited to the spindle peripheral ER and how its activity is re
Publikováno v:
Seminars in Cell & Developmental Biology. 102:73-80
The actomyosin cytoskeleton network plays a key role in a variety of fundamental cellular processes such as cell division, migration, and cell adhesion. The functions of cytoskeleton rely on its capability to receive, generate, respond to and transmi
REF52 fibroblasts have a well-developed contractile machinery, the most prominent elements of which are actomyosin stress fibers with highly ordered organization of actin and myosin IIA filaments. The relationship between contractile activity and tur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f98a879992c539e83ebe704c627fad0
https://doi.org/10.1101/2021.08.15.456175
https://doi.org/10.1101/2021.08.15.456175
Actin polymerization and crosslinking drive left-right asymmetry in single cell and cell collectives
Autor:
Weitai Huang, Jie Yan, Thiagarajan, Pakorn Kanchanawong, Barnett Sfh, Salma Jalal, Alexander D. Bershadsky, Jinrong Hu, Yee Han Tee, Goh Wj, Shidong Shi, Hui Ting Ong, Tay Iyy, Xin Ee Yong
Deviations from mirror symmetry in the development of bilateral organisms are highly stereotypic and genetically predetermined, but their mechanisms are not sufficiently understood. At the cellular level, self-organization of the actin cytoskeleton r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db6c188269a6d80ac94678af06790d94
https://doi.org/10.1101/2021.04.22.440942
https://doi.org/10.1101/2021.04.22.440942