Zobrazeno 1 - 10
of 76
pro vyhledávání: '"A. Clay Clark"'
Autor:
Isha Joglekar, A. Clay Clark
Publikováno v:
Biochemistry.
Caspases are evolutionarily conserved cysteinyl proteases that are integral in cell development and apoptosis. All apoptotic caspases evolved from a common ancestor into two distinct subfamilies with either monomeric (initiators) or dimeric (effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0779d7a3280ad5522e3443017c8ffe36
https://doi.org/10.1021/acs.biochem.3c00004
https://doi.org/10.1021/acs.biochem.3c00004
Autor:
Mithun Nag, A. Clay Clark
Publikováno v:
J Biol Chem
The apoptotic caspase subfamily evolved into two subfamilies—monomeric initiators and dimeric effectors; both subfamilies share a conserved caspase–hemoglobinase fold with a protease domain containing a large subunit and a small subunit. Sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a32e4657172602ba1d559940422754f
https://doi.org/10.1016/j.jbc.2023.103075
https://doi.org/10.1016/j.jbc.2023.103075
Autor:
Betsaida Bibo-Verdugo, Isha Joglekar, Mithun N. Karadi Giridhar, Monica L. Ramirez, Scott J. Snipas, A. Clay Clark, Marcin Poreba, Guy S. Salvesen
Publikováno v:
The Journal of biological chemistry. 298(6)
Pyroptosis is a mechanism of inflammatory cell death mediated by the activation of the prolytic protein gasdermin D by caspase-1, caspase-4, and caspase-5 in human, and caspase-1 and caspase-11 in mouse. In addition, caspase-1 amplifies inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27784112fd0e09aa33a0b3b99f90e2e2
https://pubmed.ncbi.nlm.nih.gov/35427646
https://pubmed.ncbi.nlm.nih.gov/35427646
Autor:
Liqi Yao, A. Clay Clark
All caspases evolved from a common ancestor and subsequently developed into two general classes, inflammatory or apoptotic caspases. The caspase-hemoglobinase fold has been conserved throughout nearly one billion years of evolution and is utilized fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a84697bc7981cc65481b1308089c7ba
https://doi.org/10.1101/2022.01.12.476064
https://doi.org/10.1101/2022.01.12.476064
Autor:
Isha Joglekar, Clay Clark
Publikováno v:
Journal of Biological Chemistry. 299:104129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf518f137bc0e775ff0caf43b9b2e440
https://doi.org/10.1016/j.jbc.2023.104129
https://doi.org/10.1016/j.jbc.2023.104129
Publikováno v:
Journal of Biological Chemistry. 299:104174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6625c66426960f8b859ef9b4c6b046fa
https://doi.org/10.1016/j.jbc.2023.104174
https://doi.org/10.1016/j.jbc.2023.104174
Publikováno v:
Bioscience Reports
Caspase (or cysteinyl-aspartate specific proteases) enzymes play important roles in apoptosis and inflammation, and the non-identical but overlapping specificity profiles (that is, cleavage recognition sequence) direct cells to different fates. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430ae1763e1331798dd4f095ee6b2449
http://europepmc.org/articles/PMC7846959
http://europepmc.org/articles/PMC7846959
Publikováno v:
Protein Science. 27:1857-1870
Sequence databases are powerful tools for the contemporary scientists' toolkit. However, most functional annotations in public databases are determined computationally and are not verified by a human expert. While hypotheses generated from computatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c33283bd90e22f3a0657d649d721466
https://doi.org/10.1002/pro.3494
https://doi.org/10.1002/pro.3494
Autor:
Suman Shrestha, A. Clay Clark
Publikováno v:
The Journal of Biological Chemistry
Caspases are a family of cysteinyl proteases that control programmed cell death and maintain homeostasis in multicellular organisms. The caspase family is an excellent model to study protein evolution because all caspases are produced as zymogens (pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4310123993b18d58ab7abd5af26383b
https://doi.org/10.1016/j.jbc.2021.101249
https://doi.org/10.1016/j.jbc.2021.101249
Autor:
Liqi Yao, Clay Clark
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::071335d93f0c6bcb7ca213fbde593daa
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.50
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.50