Zobrazeno 1 - 10
of 533 433
pro vyhledávání: '"A. Claudio"'
Autor:
Sonia Do Carmo, Marie-Audrey I. Kautzmann, Surjyadipta Bhattacharjee, Bokkyoo Jun, Carolyn Steinberg, Joshua T. Emmerson, Janice C. Malcolm, Quentin Bonomo, Nicolas G. Bazan, A. Claudio Cuello
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Background Brain inflammation contributes significantly to the pathophysiology of Alzheimer’s disease, and it is manifested by glial cell activation, increased production of cytokines/chemokines, and a shift in lipid mediators from a pro-h
Externí odkaz:
https://doaj.org/article/fe06cee141254d99843b373e4c10aee1
Autor:
Morgan K. Foret, Chiara Orciani, Lindsay A. Welikovitch, Chunwei Huang, A. Claudio Cuello, Sonia Do Carmo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Oxidative stress is a key contributor to AD pathology. However, the earliest role of pre-plaque neuronal oxidative stress, remains elusive. Using laser microdissected hippocampal neurons extracted from McGill-R-Thy1-APP transgenic rats we fo
Externí odkaz:
https://doaj.org/article/4578b327191040caa8b5143d7df20364
Autor:
Diego B. Piza, Benjamin W. Corrigan, Roberto A. Gulli, Sonia Do Carmo, A. Claudio Cuello, Lyle Muller, Julio Martinez-Trujillo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The role of the hippocampus in spatial navigation has been primarily studied in nocturnal mammals, such as rats, that lack many adaptations for daylight vision. Here we demonstrate that during 3D navigation, the common marmoset, a new world
Externí odkaz:
https://doaj.org/article/b7a13cdc56554181ba0ca8e3ad9ffe65
Autor:
Margherita Grasso, Annamaria Fidilio, Francesca L’Episcopo, Marilena Recupero, Concetta Barone, Maria Giulia Bacalini, Cristina Benatti, Maria Concetta Giambirtone, Giuseppe Caruso, Donatella Greco, Santo Di Nuovo, Corrado Romano, Raffaele Ferri, Serafino Buono, A. Claudio Cuello, Johanna M. C. Blom, Fabio Tascedda, Pier Vincenzo Piazza, Rafael De La Torre, Filippo Caraci
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Almost all individuals with Down’s syndrome (DS) show the characteristic neuropathological features of Alzheimer’s disease (AD) by the age of 40, yet not every individual with DS experiences symptoms of AD later in life. Similar to neurotypical d
Externí odkaz:
https://doaj.org/article/cd5049d072e047c2b7d97c1ce2424365
Autor:
Joshua T. Emmerson, Sonia Do Carmo, Yingying Liu, Ali Shalhoub, Ai Liu, Quentin Bonomo, Janice C. Malcolm, Lionel Breuillaud, Julio C. Martinez-Trujillo, A. Claudio Cuello
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106301- (2023)
Externí odkaz:
https://doaj.org/article/120e465e4baf4423a6aef6a720446a88
Autor:
Joshua T. Emmerson, Janice C. Malcolm, Sonia Do Carmo, Phuoc Nguyen, Lionel Breuillaud, Julio C. Martinez-Trujillo, A. Claudio Cuello
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106317- (2023)
In tauopathies such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), the microtubule associated protein tau undergoes conformational and posttranslational modifications in a gradual, staged pathological process. While brain atrophy and
Externí odkaz:
https://doaj.org/article/e07b9091546442c8b600434a27f0a058
Autor:
Joshua T. Emmerson, Sonia Do Carmo, Yingying Liu, Ali Shalhoub, Ai Liu, Quentin Bonomo, Janice C. Malcolm, Lionel Breuillaud, A. Claudio Cuello
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106227- (2023)
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD), clinically present with progressive cognitive decline and the deposition of neurofibrillary tangles (NFTs) in the brain. Neurovascular compromise is also prevalent i
Externí odkaz:
https://doaj.org/article/1ee81debdc664f12aa5f4ef5121d2351
Autor:
Tharick A. Pascoal, Mira Chamoun, Elad Lax, Hsiao-Ying Wey, Monica Shin, Kok Pin Ng, Min Su Kang, Sulantha Mathotaarachchi, Andrea L. Benedet, Joseph Therriault, Firoza Z. Lussier, Frederick A. Schroeder, Jonathan M. DuBois, Baileigh G. Hightower, Tonya M. Gilbert, Nicole R. Zürcher, Changning Wang, Robert Hopewell, Mallar Chakravarty, Melissa Savard, Emilie Thomas, Sara Mohaddes, Sarah Farzin, Alyssa Salaciak, Stephanie Tullo, A. Claudio Cuello, Jean-Paul Soucy, Gassan Massarweh, Heungsun Hwang, Eliane Kobayashi, Bradley T. Hyman, Bradford C. Dickerson, Marie-Christine Guiot, Moshe Szyf, Serge Gauthier, Jacob M. Hooker, Pedro Rosa-Neto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The link between amyloid and tau proteins with Alzheimer’s disease progression remains unclear. Here, the authors propose HDACs I downregulation as an element linking the deleterious effects of brain proteinopathies with disease progression.
Externí odkaz:
https://doaj.org/article/fa6fec43d93b4296b1333a2f0ecd7e12
Autor:
Pablo Galeano, Marialuisa de Ceglia, Mauricio Mastrogiovanni, Lorenzo Campanelli, Dina Medina-Vera, Nicolás Campolo, Gisela V. Novack, Cristina Rosell-Valle, Juan Suárez, Adrián Aicardo, Karen Campuzano, Eduardo M. Castaño, Sonia Do Carmo, A. Claudio Cuello, Silvina Bartesaghi, Rafael Radi, Fernando Rodríguez de Fonseca, Laura Morelli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 17009 (2023)
This work aims to clarify the effect of dietary polyunsaturated fatty acid (PUFA) intake on the adult brain affected by amyloid pathology. McGill-R-Thy1-APP transgenic (Tg) rat and 5xFAD Tg mouse models that represent earlier or later disease stages
Externí odkaz:
https://doaj.org/article/0317b715b1024862ac1ade1bc0241750
Autor:
María C. Dalmasso, Martín Arán, Pablo Galeano, Silvina Perin, Patrick Giavalisco, Pamela V. Martino Adami, Gisela V. Novack, Eduardo M. Castaño, A. Claudio Cuello, Martin Scherer, Wolfgang Maier, Michael Wagner, Steffi Riedel-Heller, Alfredo Ramirez, Laura Morelli
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Introduction: The metabolic routes altered in Alzheimer's disease (AD) brain are poorly understood. As the metabolic pathways are evolutionarily conserved, the metabolic profiles carried out in animal models of AD could be directly translated into hu
Externí odkaz:
https://doaj.org/article/c97efebf6eb0455290958f433544b64d