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A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

Autor: Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo

Publikováno v: eLife, Vol 11 (2022)

The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5, and 7 but not Hdac9. Here, we show that a transcription factor regulated genetic compensatory mecha

Externí odkaz: https://doaj.org/article/b65936c89ae145e883c6e971fd1ecada

SARM1 detection in oligodendrocytes but not Schwann cells thoughsarm1/Sarm1deletion does not perturb CNS nor PNS myelination in zebrafish and mice

Autor: Shaline V. Fazal, Clara Mutschler, Civia Z. Chen, Mark Turmaine, Chiung-Ya Chen, Yi-Ping Hsueh, Andrea Loreto, Angeles Casillas-Bajo, Hugo Cabedo, Robin J.M. Franklin, Roger A. Barker, Kelly R. Monk, Benjamin J. Steventon, Michael P. Coleman, Jose A. Gomez-Sanchez, Peter Arthur-Farraj

SARM1 is a central regulator of programmed axon death and is required to initiate axon self-destruction after traumatic and toxic insults to the nervous system. Abnormal activation of this axon degeneration pathway is increasingly recognized as a con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7eb1fe267175f2f740304601c4e3b108
https://doi.org/10.1101/2022.12.08.519209

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

Autor: Velasco-Aviles S, Patel N, Casillas-Bajo A, Frutos-Rincón L, Velasco E, Gallar J, Arthur-Farraj P, Gomez-Sanchez JA, Cabedo H

Publikováno v: eLife
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5, and 7 but not Hdac9. Here, we show that a transcription factor regulated genetic compensatory mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::1148b9f556baa565be64fe666e5424ba
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8375

A genetic compensatory mechanism regulated by

Autor: Sergio, Velasco-Aviles, Nikiben, Patel, Angeles, Casillas-Bajo, Laura, Frutos-Rincón, Enrique, Velasco, Juana, Gallar, Peter, Arthur-Farraj, Jose A, Gomez-Sanchez, Hugo, Cabedo

Publikováno v: eLife. 11

The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3636b8e52b0c2182435e4a222b58bd98
https://pubmed.ncbi.nlm.nih.gov/35076395