Výsledky vyhledávání - "A. C. van Nuenen"

Akademický článek

SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN.

Autor: Lieve E H van der Donk, Marta Bermejo-Jambrina, John L van Hamme, Mette M W Volkers, Ad C van Nuenen, Neeltje A Kootstra, Teunis B H Geijtenbeek

Publikováno v: PLoS Pathogens, Vol 19, Iss 10, p e1011735 (2023)

SARS-CoV-2 causes COVID-19, an infectious disease with symptoms ranging from a mild cold to severe pneumonia, inflammation, and even death. Although strong inflammatory responses are a major factor in causing morbidity and mortality, superinfections

Externí odkaz: https://doaj.org/article/c010de220744407b84ce2a6c90caee68

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Robust Vaccine-Induced as Well as Hybrid B- and T-Cell Immunity across SARS-CoV-2 Vaccine Platforms in People with HIV

Autor: Myrthe L. Verburgh, Lisa van Pul, Marloes Grobben, Anders Boyd, Ferdinand W. N. M. Wit, Ad C. van Nuenen, Karel A. van Dort, Khadija Tejjani, Jacqueline van Rijswijk, Margreet Bakker, Lia van der Hoek, Maarten F. Schim van der Loeff, Marc van der Valk, Marit J. van Gils, Neeltje A. Kootstra, Peter Reiss

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT Few studies have comprehensively compared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced and hybrid B- and T-cell responses in people with HIV (PWH) to those in comparable controls without HIV. We included 195 P

Externí odkaz: https://doaj.org/article/e41f2eae979f452e9fbb2e5eaf37db88

Zobrazit plný text záznamu

Akademický článek

Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo

Autor: Guzmán Alvarez, Lisa van Pul, Xavier Robert, Zoraima Artía, Ad C. van Nuenen, Mathieu Long, Natalia Sierra, Williams Porcal, Neeltje A. Kootstra, Christophe Guillon

Publikováno v: BMC Pharmacology and Toxicology, Vol 23, Iss 1, Pp 1-13 (2022)

Abstract The capsid (CA) subunit of the HIV-1 Gag polyprotein is involved in several steps of the viral cycle, from the assembly of new viral particles to the protection of the viral genome until it enters into the nucleus of newly infected cells. As

Externí odkaz: https://doaj.org/article/6d767b2046a44266a3bb8e51d3d43477

Zobrazit plný text záznamu

Akademický článek

Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction

Autor: Zita Kruize, Ad C. van Nuenen, Stan W. van Wijk, Arginell F. Girigorie, Karel A. van Dort, Thijs Booiman, Neeltje A. Kootstra

Publikováno v: Viruses, Vol 13, Iss 3, p 423 (2021)

Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC). He

Externí odkaz: https://doaj.org/article/d9addb0636644bda8fd7da4b09037f9c

Zobrazit plný text záznamu

Plný text ve formátu HTML

SARS-CoV-2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs

Autor: Lieve E.H. van der Donk, Julia Eder, John L. van Hamme, Philip J. M. Brouwer, Mitch Brinkkemper, Ad C. van Nuenen, Marit J. van Gils, Rogier W. Sanders, Neeltje A. Kootstra, Marta Bermejo‐Jambrina, Teunis B. H. Geijtenbeek

Publikováno v: European journal of immunology, 52(4), 646-655. Wiley-VCH Verlag

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), an infectious disease characterized by strong induction of inflammatory cytokines, progressive lung inflammation, and potentially multiorgan dysf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701b0f6191db243c478a8f33e23a5dd2
https://pubmed.ncbi.nlm.nih.gov/35099061

Zobrazit plný text záznamu

CD9 and ITGA3 are regulated during HIV-1 infection in macrophages to support viral replication

Autor: Thijs Booiman, Riccardo Di Vincenzo, Fernando O. Martinez, Ad C. van Nuenen, Karel A. van Dort, Zita Kruize, Viviana Cobos Jiménez, Neeltje A. Kootstra

Publikováno v: Virology, 562, 9-18. Academic Press Inc.
Kruize, Z, Cobos Jiménez, V, Martinez, F O, Di Vincenzo, R, van Dort, K A, van Nuenen, A C, Booiman, T & Kootstra, N A 2021, ' CD9 and ITGA3 are regulated during HIV-1 infection in macrophages to support viral replication ', Virology, vol. 562, pp. 9-18 . https://doi.org/10.1016/j.virol.2021.07.002

Monocytes/macrophages are important target cells for HIV-1. Here, we investigated whether HIV-1 induces changes in the macrophage gene expression profile to support viral replication. We observed that the macrophage gene expression profiles dramatica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7c07f7eafb19ee90c943bccde602a5
https://research.vumc.nl/en/publications/1fcc638f-764c-4654-bcbc-e918d55b7887

Zobrazit plný text záznamu

SARS-CoV-2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs

Autor: Julia Eder, Teunis B. H. Geijtenbeek, Ad C. van Nuenen, Marta Bermejo-Jambrina, Marit J. van Gils, Neeltje A. Kootstra, Philip J. M. Brouwer, Lieve E. H. van der Donk, Rogier W. Sanders, John L. van Hamme, Mitch Brinkkemper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c77c21cbe00f0ae146e9a9dc69c67989
https://doi.org/10.1101/2021.09.02.458667

Zobrazit plný text záznamu

Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans

Autor: Ad C. van Nuenen, Philip J. M. Brouwer, Marcel Spaargaren, Tanja M. Kaptein, Bernadien M. Nijmeijer, Godelieve J. de Bree, Julia Eder, John L. van Hamme, Marta Bermejo-Jambrina, Marit J. van Gils, Leanne C. Helgers, Neeltje A. Kootstra, Killian E Vlaming, Rogier W. Sanders, Teunis B. H. Geijtenbeek

Publikováno v: The EMBO Journal
EMBO journal, 40(20):e106765. Wiley-Blackwell

The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and outbreaks of new variants highlight the need for preventive treatments. Here, we identified heparan sulfate proteoglycans as attachment receptors for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c23aa9d7a54b1c7f07fb3e8c020f7f
http://europepmc.org/articles/PMC8521309

Zobrazit plný text záznamu

Akademický článek

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag.

Autor: Esther F Gijsbers, K Anton Feenstra, Ad C van Nuenen, Marjon Navis, Jaap Heringa, Hanneke Schuitemaker, Neeltje A Kootstra

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e81235 (2013)

Expression of HLA-B*57 and the closely related HLA-B*58:01 are associated with prolonged survival after HIV-1 infection. However, large differences in disease course are observed among HLA-B*57/58:01 patients. Escape mutations in CTL epitopes restric

Externí odkaz: https://doaj.org/article/24e83fc70f6347449d9f29e4b1e3d046

Zobrazit plný text záznamu

Plasma MicroRNA levels are associated with Hepatitis B e antigen status and treatment response in chronic Hepatitis B patients

Autor: Meike H. van der Ree, R. Bart Takkenberg, Zita Kruize, Neeltje A. Kootstra, Ad C. van Nuenen, Hendrik W. Reesink, Louis Jansen, Karel A. van Dort

Publikováno v: Journal of Infectious Diseases, 215(9), 1421-1429. Oxford University Press
Journal of infectious diseases, 215(9), 1421-1429. Oxford University Press
Van Der Ree, M H, Jansen, L, Kruize, Z, Van Nuenen, A C, Van Dort, K A, Bart Takkenberg, R, Reesink, H W & Kootstra, N A 2017, ' Plasma MicroRNA levels are associated with Hepatitis B e antigen status and treatment response in chronic Hepatitis B patients ', Journal of Infectious Diseases, vol. 215, no. 9, pp. 1421-1429 . https://doi.org/10.1093/infdis/jix140

Background. Hepatitis B virus (HBV) modulates microRNA (miRNA) expression to support viral replication. The aim of this study was to identify miRNAs associated with hepatitis B e antigen (HBeAg) status and response to antiviral therapy in patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda5550a31345c65a3be1a38fec5596f
http://www.scopus.com/inward/record.url?scp=85021878205&partnerID=8YFLogxK

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání