Zobrazeno 1 - 10
of 1 179
pro vyhledávání: '"A. C. Sen"'
Autor:
Darshana Poddar, Nikhil Sharma, Tomoaki Ogino, Xu Qi, Patricia M. Kessler, Hiran Mendries, Ranjan Dutta, Ganes C. Sen
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT The interferon (IFN) system protects mammals from diseases caused by virus infections. IFN synthesis is induced by pattern recognition receptor signaling pathways activated by virus infection. IFN is secreted from the infected cells and acts
Externí odkaz:
https://doaj.org/article/f38230ffa2eb43bfbd81376250bad105
Autor:
Nikhil Sharma, Ganes C. Sen
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101836- (2022)
Summary: Antisense locked nucleic acid (LNA) technology has been widely used for silencing microRNAs with enhanced specificity and efficiency. In this protocol, we first describe the procedure for targeted intracranial delivery of LNAs to silence mic
Externí odkaz:
https://doaj.org/article/c4a1ff92728947fa855025f6a3d91345
Autor:
Shine Kumar, Danish Memon, Manu Raj, Amitabh C. Sen, Jessin P. Jayasankar, Sreelakshmi P. Leeladharan, Abish Sudhakar, Raman K. Kumar
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Acute vasodilator testing (AVT) identifies acute responders for initiation of calcium channel blockers in pulmonary arterial hypertension (PAH) and operability in congenital heart disease (CHD). We sought to determine the feasibility of intr
Externí odkaz:
https://doaj.org/article/d916ba36cb5a40bb8bb519d3e70a93b7
Autor:
Yun Liao, Junjie Zhao, Katarzyna Bulek, Fangqiang Tang, Xing Chen, Gang Cai, Shang Jia, Paul L. Fox, Emina Huang, Theresa T. Pizarro, Matthew F. Kalady, Mark W. Jackson, Shideng Bao, Ganes C. Sen, George R. Stark, Christopher J. Chang, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
STEAP4 promotes the uptake of copper, and copper is known to be enhanced in cancer tissues. Here, the authors show that STEAP4 is induced by IL17, which is increased in inflamed tissues, consequently the increased copper levels activate NFκB signall
Externí odkaz:
https://doaj.org/article/6df31ef881b642eba3b5296a7360af9c
Publikováno v:
Indian Journal of Ophthalmology, Vol 68, Iss 1, Pp 91-98 (2020)
Purpose: To report the outcomes of pars-plana approach for the management of brunescent cataract in eyes with severe microcornea and associated chorio-retinal coloboma. Methods: This was a retrospective, single center, interventional case series perf
Externí odkaz:
https://doaj.org/article/0ac55e2bdae84684a2366418d43e179f
Publikováno v:
Indian Journal of Ophthalmology, Vol 68, Iss 6, Pp 1193-1196 (2020)
We present a case of persistent macular hole (MH) having an apical diameter of 140 microns and a basal diameter of 530 microns following a combined phacoemulsification and MH surgery. Considering post-operative cystoid macular edema (CME) as the poss
Externí odkaz:
https://doaj.org/article/e4bf77ffe14f4e1c8fc82128c128a46c
Autor:
Soumya Kundu, Fareeha Saadi, Sourodip Sengupta, Gisha Rose Antony, Vineeth A. Raveendran, Rahul Kumar, Mithila Ashok Kamble, Lucky Sarkar, Amy Burrows, Debnath Pal, Ganes C. Sen, Jayasri Das Sarma
Publikováno v:
Brain Disorders, Vol 4, Iss , Pp 100021- (2021)
Coronaviruses have emerged as alarming pathogens owing to their inherent ability of genetic variation and cross-species transmission. Coronavirus infection burdens the endoplasmic reticulum (ER.), causes reactive oxygen species production and induces
Externí odkaz:
https://doaj.org/article/d81a1861912741359bd1986f58fa8c49
Autor:
Chenyao Wang, Nikhil Sharma, Manoj Veleeparambil, Patricia M. Kessler, Belinda Willard, Ganes C. Sen
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT The nature and the intensity of innate immune response to virus infection determine the course of pathogenesis in the host. Among the many pathogen-associated molecular pattern recognition receptors, STING, an endoplasmic reticulum (ER)-asso
Externí odkaz:
https://doaj.org/article/42def7bec8994298a479d134c00e4bc6
Autor:
Lu Sun, You Li, Ichiro Misumi, Olga González-López, Lucinda Hensley, John M Cullen, David R McGivern, Mami Matsuda, Ryosuke Suzuki, Ganes C Sen, Asuka Hirai-Yuki, Jason K Whitmire, Stanley M Lemon
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009960 (2021)
HAV-infected Ifnar1-/- mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signalin
Externí odkaz:
https://doaj.org/article/b97fa5a3c6024389911f79c898d10f9e
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009950 (2021)
STING is a nodal point for cellular innate immune response to microbial infections, autoimmunity and cancer; it triggers the synthesis of the antiviral proteins, type I interferons. Many DNA viruses, including Herpes Simplex Virus 1 (HSV1), trigger S
Externí odkaz:
https://doaj.org/article/0b799e19f3204017ab8357b547c7afe2