Výsledky vyhledávání - "A. C. S. Gondim"

A binuclear Fe(iii)/quinizarin complex as a structural model for anthracycline drugs binding to iron

Autor: Juliana S. do Nascimento, Aurideia P. de Sousa, Ana C. S. Gondim, Eduardo H. S. Sousa, Edson H. Teixeira, Luiz Gonzaga do Nascimento Neto, Beatriz Pinheiro Bezerra, Alejandro Pedro Ayala, Alzir A. Batista, Igor F. Vasconcelos, Francisco G. S. Oliveira, Alda K. M. Holanda

Publikováno v: New Journal of Chemistry. 46:5515-5525

Quinizarin, an anthracyclin-like compound, was used to prepare a binuclear complex, [(Fe(cyclam))2Qz]Cl(PF6)3, which showed damage to DNA with glutathione. This mimic of anthracyclin drugs might explain undesired side effects of these compounds.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc14c921199e4e1c43f561f3b378d720
https://doi.org/10.1039/d1nj04087a

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Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case

Autor: Eduardo H.S. Sousa, Izaura C.N. Diógenes, Tércio de F. Paulo, Alexandre Lopes Andrade, Idalina M.M. de Carvalho, Edinaira Nunes, Edson Holanda Teixeira, Luiz Gonzaga de França Lopes, Otaciro R. Nascimento, Mayron Alves de Vasconcelos, Ana C. S. Gondim, Luiz Augusto Basso, Davila Zampieri, Anne Drumond Villela, Luiz Gonzaga do Nascimento Neto, Adolfo I. B. Romo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Aldehydes and acyl hydrazines have been employed in a conjugation reaction that produces an acyl hydrazone bridge. A drawback to this linkage is hydrolysis, which prevents its broader use in a controllable manner. We have developed a new strategy for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98395e78e53a8c31f606eb4f2545276
https://doi.org/10.1039/c9qi01172b

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Akademický článek

Efeito do glutaraldeído na adsorção de extrato proteico da Ipomoea Batatas (L) Lam na superficie de uma zeólita analcima Effect of the glutaraldeide on the adsorption of proteic extract of the Ipomoea Batatas (L) Lam in analcime zeolite surface

Autor: A. C. S. Gondim, L. R. D. da Silva

Publikováno v: Cerâmica, Vol 51, Iss 319, Pp 219-224 (2005)

A zeólita analcime (Na16Al16Si32O96.nH 2O) foi submetida a ataque ácido com HCl 0,25 mol.L-1, seguido da funcionalização com glutaraldeído, foi imersa em extrato protéico obtido da polpa da batata-doce (Ipomoea Batatas (L) Lam), que tem em sua

Externí odkaz: https://doaj.org/article/38e4740d63f8443ea36b213e6b280b3b

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Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity

Autor: Sam Noppen, Suzete Roberta da Silva, Sandra Liekens, Kyria S. Nascimento, Ana C. S. Gondim, Leen Mathys, Peter J. Sadler, Benildo Sousa Cavada, Cintia Renata Costa Rocha, Celso Shiniti Nagano, Jan Balzarini, Alexandre Holanda Sampaio

Publikováno v: MedChemComm

Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc279b50a82ea0fd4c31d4f1c96204ce

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Electrochemical, mechanistic, and DFT studies of amine derived diphosphines containing Ru(II)-cymene complexes with potent

Autor: Juliana P, da Silva, Otávio, Fuganti, M Gabriela, Kramer, Gianella, Facchin, Lucas E N, Aquino, Javier, Ellena, Davi F, Back, Ana C S, Gondim, Eduardo H S, Sousa, Luiz G F, Lopes, Silvane, Machado, Ivelise D L, Guimarães, Karen, Wohnrath, Márcio P, de Araujo

Publikováno v: Dalton transactions (Cambridge, England : 2003). 49(45)

Complexes with general formula [RuCl(η6-p-cymene)(P-NR-P)]X (R = CH2Py (Py = pyridine) - [1a]+, CH2Ph (Ph = phenyl) - [1b]+, Ph - [1c] and p-tol (p-tol = p-tolyl) - [1d]+; X = PF6- or BF4-) were evaluated as cytotoxic agents against two cancer cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8cc730febe7e3a2175b9457367fd22c
https://pubmed.ncbi.nlm.nih.gov/33206073

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Electrochemical, mechanistic, and DFT studies of amine derived diphosphines containing Ru(ii)-cymene complexes with potent in vitro cytotoxic activity against HeLa and triple-negative breast cancer cells MDA-MB-231

Autor: Silvane Machado, Javier Ellena, Ana C. S. Gondim, Karen Wohnrath, Otávio Fuganti, Luiz Gonzaga de França Lopes, Ivelise Dimbarre Lao Guimarães, M. Gabriela Kramer, Eduardo H.S. Sousa, Gianella Facchin, Márcio P. de Araujo, Davi F. Back, Juliana P. da Silva, Lucas E. N. Aquino

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Complexes with general formula [RuCl(η6-p-cymene)(P–NR–P)]X (R = CH2Py (Py = pyridine) – [1a]+, CH2Ph (Ph = phenyl) – [1b]+, Ph – [1c] and p-tol (p-tol = p-tolyl) – [1d]+; X = PF6− or BF4−) were evaluated as cytotoxic agents against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d254bd00f068b82652f677ea5b206834

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Antimicrobial activity of cis-[Ru(bpy)2(L)(L′)]+ complexes, where L = 4-(4-chlorobenzoyl)pyridine or 4-(benzoyl)pyridine and L′ = Cl− or CO

Autor: Eduardo H.S. Sousa, Mayron Alves de Vasconcelos, Aurideia P. de Sousa, Luiz Gonzaga de França Lopes, Alda K.M. Holanda, Javier Ellena, Ana C. S. Gondim, Edson Holanda Teixeira, Peter C. Ford

Publikováno v: Polyhedron. 144:88-94

The cis-[Ru(bpy)2(clbzpy)(Cl)](PF6) complex (I), where clbzpy = 4-(4-chlorobenzoyl)pyridine and bpy = 2,2′-bipyridine, was prepared and fully characterized. Blue light photolysis (453 nm) of this compound in aqueous solution led to release of clbzp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41f4901f62ee13d225ba7f53a4bb7872
https://doi.org/10.1016/j.poly.2018.01.002

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Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding

Autor: Tércio de F. Paulo, Luiz Gonzaga de França Lopes, Idalina M.M. de Carvalho, Ana C. S. Gondim, Eduardo H.S. Sousa, Rômulo A. Ando, Marcelo Henrique Gehlen, Edson Holanda Teixeira, Felipe Diógenes Abreu, Mayron Alves de Vasconcelos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Ruthenium polypyridine complexes have shown promise as agents for photodynamic therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To accomplish these tasks, it is important to have at least target selectivity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179bacd9bbce1f7facdd30709542a6ed
https://doi.org/10.1021/acs.inorgchem.7b01108

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