A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope

Autor: Erin E. Grundy, Lauren C. Shaw, Loretta Wang, Abigail V. Lee, James Castro Argueta, Daniel J. Powell, Mario Ostrowski, R. Brad Jones, C. Russell Y. Cruz, Heather Gordish-Dressman, Nicole P. Chappell, Catherine M. Bollard, Katherine B. Chiappinelli

Publikováno v: Mobile DNA, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Transposable elements (TEs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of tumor-associated antigens. In ovarian cancer (OC), protein from the TE ERV-K is frequ

Externí odkaz: https://doaj.org/article/ae60226c036b4df8a06919f4dc2441a1

Next-generation of BBQ analogues that selectively target breast cancer

Autor: Jennifer R. Baker, Jayne Gilbert, Nicholas S. O’Brien, Cecilia C. Russell, Adam McCluskey, Jennette A. Sakoff

Publikováno v: Frontiers in Chemistry, Vol 12 (2024)

We previously reported on the interaction of 10-chloro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one (10-Cl-BBQ) with the Aryl hydrocarbon Receptor (AhR) and selective growth inhibition in breast cancer cell lines. We now report on a library

Externí odkaz: https://doaj.org/article/827e77419dfb41b8b950e383c0565803

Community-led vertebrate pest management in urban areas: barriers and motivations

Autor: Rosie V Gerolemou, James C Russell, Margaret C Stanley

Publikováno v: Ecology and Society, Vol 29, Iss 3, p 11 (2024)

Residential green spaces in cities can make a significant contribution to urban conservation. To engage urban residents in conservation, we need to understand what influences participation. We interviewed leaders of community conservation groups and

Externí odkaz: https://doaj.org/article/186bb6bc25c44260b7f13d7d7f2c8597

Global assessment of marine plastic exposure risk for oceanic birds

Autor: Bethany L. Clark, Ana P. B. Carneiro, Elizabeth J. Pearmain, Marie-Morgane Rouyer, Thomas A. Clay, Win Cowger, Richard A. Phillips, Andrea Manica, Carolina Hazin, Marcus Eriksen, Jacob González-Solís, Josh Adams, Yuri V. Albores-Barajas, Joanna Alfaro-Shigueto, Maria Saldanha Alho, Deusa Teixeira Araujo, José Manuel Arcos, John P. Y. Arnould, Nadito J. P. Barbosa, Christophe Barbraud, Annalea M. Beard, Jessie Beck, Elizabeth A. Bell, Della G. Bennet, Maud Berlincourt, Manuel Biscoito, Oskar K. Bjørnstad, Mark Bolton, Katherine A. Booth Jones, John J. Borg, Karen Bourgeois, Vincent Bretagnolle, Joël Bried, James V. Briskie, M. de L. Brooke, Katherine C. Brownlie, Leandro Bugoni, Licia Calabrese, Letizia Campioni, Mark J. Carey, Ryan D. Carle, Nicholas Carlile, Ana R. Carreiro, Paulo Catry, Teresa Catry, Jacopo G. Cecere, Filipe R. Ceia, Yves Cherel, Chang-Yong Choi, Marco Cianchetti-Benedetti, Rohan H. Clarke, Jaimie B. Cleeland, Valentina Colodro, Bradley C. Congdon, Jóhannis Danielsen, Federico De Pascalis, Zoe Deakin, Nina Dehnhard, Giacomo Dell’Omo, Karine Delord, Sébastien Descamps, Ben J. Dilley, Herculano A. Dinis, Jerome Dubos, Brendon J. Dunphy, Louise M. Emmerson, Ana Isabel Fagundes, Annette L. Fayet, Jonathan J. Felis, Johannes H. Fischer, Amanda N. D. Freeman, Aymeric Fromant, Giorgia Gaibani, David García, Carina Gjerdrum, Ivandra Soeli Gonçalves Correia Gomes, Manuela G. Forero, José P. Granadeiro, W. James Grecian, David Grémillet, Tim Guilford, Gunnar Thor Hallgrimsson, Luke R. Halpin, Erpur Snær Hansen, April Hedd, Morten Helberg, Halfdan H. Helgason, Leeann M. Henry, Hannah F. R. Hereward, Marcos Hernandez-Montero, Mark A. Hindell, Peter J. Hodum, Simona Imperio, Audrey Jaeger, Mark Jessopp, Patrick G. R. Jodice, Carl G. Jones, Christopher W. Jones, Jón Einar Jónsson, Adam Kane, Sven Kapelj, Yuna Kim, Holly Kirk, Yann Kolbeinsson, Philipp L. Kraemer, Lucas Krüger, Paulo Lago, Todd J. Landers, Jennifer L. Lavers, Matthieu Le Corre, Andreia Leal, Maite Louzao, Jeremy Madeiros, Maria Magalhães, Mark L. Mallory, Juan F. Masello, Bruno Massa, Sakiko Matsumoto, Fiona McDuie, Laura McFarlane Tranquilla, Fernando Medrano, Benjamin J. Metzger, Teresa Militão, William A. Montevecchi, Rosalinda C. Montone, Leia Navarro-Herrero, Verónica C. Neves, David G. Nicholls, Malcolm A. C. Nicoll, Ken Norris, Steffen Oppel, Daniel Oro, Ellie Owen, Oliver Padget, Vítor H. Paiva, David Pala, Jorge M. Pereira, Clara Péron, Maria V. Petry, Admilton de Pina, Ariete T. Moreira Pina, Patrick Pinet, Pierre A. Pistorius, Ingrid L. Pollet, Benjamin J. Porter, Timothée A. Poupart, Christopher D. L. Powell, Carolina B. Proaño, Júlia Pujol-Casado, Petra Quillfeldt, John L. Quinn, Andre F. Raine, Helen Raine, Iván Ramírez, Jaime A. Ramos, Raül Ramos, Andreas Ravache, Matt J. Rayner, Timothy A. Reid, Gregory J. Robertson, Gerard J. Rocamora, Dominic P. Rollinson, Robert A. Ronconi, Andreu Rotger, Diego Rubolini, Kevin Ruhomaun, Asunción Ruiz, James C. Russell, Peter G. Ryan, Sarah Saldanha, Ana Sanz-Aguilar, Mariona Sardà-Serra, Yvan G. Satgé, Katsufumi Sato, Wiebke C. Schäfer, Stefan Schoombie, Scott A. Shaffer, Nirmal Shah, Akiko Shoji, Dave Shutler, Ingvar A. Sigurðsson, Mónica C. Silva, Alison E. Small, Cecilia Soldatini, Hallvard Strøm, Christopher A. Surman, Akinori Takahashi, Vikash R. V. Tatayah, Graeme A. Taylor, Robert J. Thomas, David R. Thompson, Paul M. Thompson, Thorkell L. Thórarinsson, Diego Vicente-Sastre, Eric Vidal, Ewan D. Wakefield, Susan M. Waugh, Henri Weimerskirch, Heiko U. Wittmer, Takashi Yamamoto, Ken Yoda, Carlos B. Zavalaga, Francis J. Zino, Maria P. Dias

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial

Externí odkaz: https://doaj.org/article/56773c26a1074a7abc72110b0e673856

Durable vision improvement after a single intravitreal treatment with antisense oligonucleotide in CEP290-LCA: Replication in two eyes

Autor: Artur V. Cideciyan, Samuel G. Jacobson, Allen C. Ho, Malgorzata Swider, Alexander Sumaroka, Alejandro J. Roman, Vivian Wu, Robert C. Russell, Iryna Viarbitskaya, Alexandra V. Garafalo, Michael R. Schwartz, Aniz Girach

Publikováno v: American Journal of Ophthalmology Case Reports, Vol 32, Iss , Pp 101873- (2023)

Purpose: An intravitreally injected antisense oligonucleotide, sepofarsen, was designed to modulate splicing within retinas of patients with severe vision loss due to deep intronic c.2991 + 1655A > G variant in the CEP290 gene. A previous report show

Externí odkaz: https://doaj.org/article/f39e007917e243f9b76ef7bb46b524bd