Výsledky vyhledávání - "A. C. P. Hekman"

Loss of heterozygosity on chromosome 9 and loss of chromosome 9 copy number are separate events in the pathogenesis of transitional cell carcinoma of the bladder

Autor: Ellen C. Zwarthoff, A. C. P. Hekman, Kees J. Vissers, A.A.G. Van Tilborg, T.H. Van Der Kwast

Publikováno v: International Journal of Cancer, 75(1), 9-14. Wiley-Liss Inc.

The most frequent genetic aberration found in transitional cell carcinoma (TCC) of the bladder involves chromosome 9. Loss of heterozygosity (LOH) analyses show deletions of both chromosome 9p and 9q, while in situ hybridization studies suggest a sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e79c4e940255aaa42b52fea7d4e4df
https://doi.org/10.1002/(sici)1097-0215(19980105)75:1<9::aid-ijc2>3.0.co

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Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton

Autor: Ellen C. Zwarthoff, Magda A. Meester-Smoor, Karel H. M. van Wely, A. C. P. Hekman, Marcel Vermeij, Christl Vermey-Keers, Marjolein J. L. van Helmond, Anco C. Molijn, Peter Riegman

Publikováno v: Molecular and Cellular Biology, 25(10), 4229-4236. American Society for Microbiology

Fusion of the MN1 gene to TEL (ETV6) results in myeloid leukemia. The fusion protein combines the transcription activating domain of MN1 and the DNA binding domain of TEL and is thought to act as a deranged transcription factor. In addition, disrupti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c405dcc7a1c08a469b45a9aa70c9218e
https://pubmed.ncbi.nlm.nih.gov/15870292

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Generation of antibodies against the neurofibromatosis type 2 gene product utilising the synthetic peptide strategy

Autor: Peter Riegman, Wim Boersma, Dirk Bootsma, Ellen C. Zwarthoff, Connie van Holten-Neelen, Michael A. den Bakker, Theo H. van der Kwast, Fred T. Bosman, A. C. P. Hekman

Publikováno v: Cancer Genetics and Cytogenetics. 77:174

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5787e686bbc8c3c8ffe18168fe530878
https://doi.org/10.1016/0165-4608(94)90333-6

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Interferon expression in the testes of transgenic mice leads to sterility

Autor: A. H. Mulder, Jan Trapman, A. C. P. Hekman, Ellen C. Zwarthoff, J. L. M. van Gaalen

Publikováno v: Journal of Biological Chemistry. 263:12151-12155

A plasmid containing the mouse interferon-alpha 1 gene under control of the mouse metallothionein-I promoter was used for the construction of transgenic mice. Four transgenic mice (two males and two females) were obtained containing 1 to over 10 copi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::781d46f43b5100ac821ccf90cb93efac
https://doi.org/10.1016/s0021-9258(18)37906-7

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The biological activity of interferon alpha is influenced by two distinct regions in the protein

Autor: Margreet van Heuvel, Kor van As, Ellen C. Zwarthoff, Jan Trapman, Jaap Bosveld, A. C. P. Hekman

Publikováno v: Biochemical and biophysical research communications. 164(1)

With the aim to assign differences in activity between murine interferon-alpha 1 and -alpha 4 to specific amino acids, we have constructed hybrid genes and analysed the antiviral properties of the corresponding hybrid proteins. The hybrid genes were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3cc58e3a61ad11214e900df8edf3d4
https://pubmed.ncbi.nlm.nih.gov/2508635

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