Zobrazeno 1 - 10
of 386
pro vyhledávání: '"A. C. Lay"'
Autor:
J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of fu
Externí odkaz:
https://doaj.org/article/051986d29ba44b0d9f2cf3bc9a46a0bb
Autor:
Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H. Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Human Kidney Tissue Resource Study Group, Maciej Tomaszewski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-
Externí odkaz:
https://doaj.org/article/f5e9da19c88d4024b4071ce5130ced06
Autor:
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109749- (2024)
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes i
Externí odkaz:
https://doaj.org/article/961bd36ce95841e4b8f27817b6223d15
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Although the majority of existing literature has suggested positive effects of housework on older adults’ health and survival rate, the underlying mechanisms of such effects remain unclear. To address potential mechanisms, the p
Externí odkaz:
https://doaj.org/article/1f37182af9884d09b6350bd2b0fbdf43
Autor:
Betty R. McConn, Kouassi R. Kpodo, Jean E. Rivier, Dominic P. Behan, Brian T. Richert, John S. Radcliffe, Donald C. Lay, Jay S. Johnson
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The study objective was to evaluate the interaction between corticotrophin releasing factor (CRF) receptor signaling and prophylactic antibiotic administration on intestinal physiology in newly weaned and transported pigs. Pigs (n = 56; 5.70 ± 1.05
Externí odkaz:
https://doaj.org/article/612fa2e004574c2bb7ec2d63bf038080
Autor:
Betty R. McConn, Allan P. Schinckel, Lindsey Robbins, Brianna N. Gaskill, Angela R. Green-Miller, Donald C. Lay, Jay S. Johnson
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background Although thermal indices have been proposed for swine, none to our knowledge differentiate by reproductive stage or predict thermal comfort using behavioral and physiological data. The study objective was to develop a behavior and
Externí odkaz:
https://doaj.org/article/0c0eba8ce75541a18330e264a978a259
Autor:
Karina Barreiro, Abigail C. Lay, German Leparc, Van Du T. Tran, Marcel Rosler, Lusyan Dayalan, Frederic Burdet, Mark Ibberson, Richard J. M. Coward, Tobias B. Huber, Bernhard K. Krämer, Denis Delic, Harry Holthofer
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 2, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EV) are membranous particles secreted by all cells and found in body fluids. Established EV contents include a variety of RNA species, proteins, lipids and metabolites that are considered to reflect the physiological
Externí odkaz:
https://doaj.org/article/6c45737f12364881b6e1bf461d8da207
Autor:
Natalie C. Finch, Sarah S. Fawaz, Chris R. Neal, Matthew J. Butler, Vivian K. Lee, Andrew J. Salmon, Abigail C. Lay, Megan Stevens, Lusyan Dayalan, Hamid Band, Harry H. Mellor, Steven J. Harper, David T. Shima, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell
Publikováno v:
University of Bristol-PURE
J Am Soc Nephrol
Finch, N C, Fawaz, S, Neal, C R, Butler, M J, Salmon, A, Lay, A C, Stevens, M, Mellor, H H, Harper, S J, Welsh, G I, Foster, R & Satchell, S C 2022, ' Reduced glomerular filtration in diabetes is attributable to loss of density and increased resistance of glomerular endothelial cell fenestrations ', Journal of the American Society of Nephrology, vol. 33, no. 6, pp. 1120-1136 . https://doi.org/10.1681/ASN.2021030294
J Am Soc Nephrol
Finch, N C, Fawaz, S, Neal, C R, Butler, M J, Salmon, A, Lay, A C, Stevens, M, Mellor, H H, Harper, S J, Welsh, G I, Foster, R & Satchell, S C 2022, ' Reduced glomerular filtration in diabetes is attributable to loss of density and increased resistance of glomerular endothelial cell fenestrations ', Journal of the American Society of Nephrology, vol. 33, no. 6, pp. 1120-1136 . https://doi.org/10.1681/ASN.2021030294
Background: Glomerular endothelial cell (GEnC) fenestrations are recognised as an essential component of the glomerular filtration barrier, yet little is known about how they are regulated and their role in disease.Methods: We comprehensively charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8640d1b05cba480fd85861f51a3d378
https://doi.org/10.1681/asn.2021030294
https://doi.org/10.1681/asn.2021030294
Publikováno v:
AIAA SCITECH 2023 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0451a687684fe3811879b068722acbc5
https://doi.org/10.2514/6.2023-0819
https://doi.org/10.2514/6.2023-0819
Publikováno v:
Social Psychological and Personality Science. 13:946-956
Solitude––the absence of social interaction––can bring both positive and negative experiences. Drawing on self-determination theory, we conducted three experience sampling studies to investigate quality of experience and dispositions associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165b52bc78b0f0862ece2c0e26b0c67b
https://doi.org/10.1177/19485506211048066
https://doi.org/10.1177/19485506211048066