Zobrazeno 1 - 10
of 388
pro vyhledávání: '"A. C. Lay"'
Autor:
J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of fu
Externí odkaz:
https://doaj.org/article/051986d29ba44b0d9f2cf3bc9a46a0bb
Autor:
Abigail C. Lay, Van Du T. Tran, Viji Nair, Virginie Betin, Jennifer A. Hurcombe, Alexandra F. Barrington, Robert JP Pope, Frédéric Burdet, Florence Mehl, Dmytro Kryvokhyzha, Abrar Ahmad, Matthew C. Sinton, Philip Lewis, Marieangela C. Wilson, Rajasree Menon, Edgar Otto, Kate J. Heesom, Mark Ibberson, Helen C. Looker, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Simon C. Satchell, Maria F. Gomez, Richard J. M. Coward, BEAt-DKD consortium
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Diabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial
Externí odkaz:
https://doaj.org/article/b623e2a205714bcbbfbb61ff109ce900
Autor:
Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H. Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Human Kidney Tissue Resource Study Group, Maciej Tomaszewski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-
Externí odkaz:
https://doaj.org/article/f5e9da19c88d4024b4071ce5130ced06
Autor:
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109749- (2024)
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes i
Externí odkaz:
https://doaj.org/article/961bd36ce95841e4b8f27817b6223d15
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Although the majority of existing literature has suggested positive effects of housework on older adults’ health and survival rate, the underlying mechanisms of such effects remain unclear. To address potential mechanisms, the p
Externí odkaz:
https://doaj.org/article/1f37182af9884d09b6350bd2b0fbdf43
Autor:
Betty R. McConn, Kouassi R. Kpodo, Jean E. Rivier, Dominic P. Behan, Brian T. Richert, John S. Radcliffe, Donald C. Lay, Jay S. Johnson
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The study objective was to evaluate the interaction between corticotrophin releasing factor (CRF) receptor signaling and prophylactic antibiotic administration on intestinal physiology in newly weaned and transported pigs. Pigs (n = 56; 5.70 ± 1.05
Externí odkaz:
https://doaj.org/article/612fa2e004574c2bb7ec2d63bf038080
Autor:
Karina Barreiro, Abigail C. Lay, German Leparc, Van Du T. Tran, Marcel Rosler, Lusyan Dayalan, Frederic Burdet, Mark Ibberson, Richard J. M. Coward, Tobias B. Huber, Bernhard K. Krämer, Denis Delic, Harry Holthofer
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 2, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EV) are membranous particles secreted by all cells and found in body fluids. Established EV contents include a variety of RNA species, proteins, lipids and metabolites that are considered to reflect the physiological
Externí odkaz:
https://doaj.org/article/6c45737f12364881b6e1bf461d8da207
Autor:
Ryan Langdon, Matthew Suderman, Oliver Whitehurst, Hannah R. Elliott, Luke Mahoney, Matthew A. Lee, Caroline L. Relton, Giulia Mancano, Abigail C. Lay, Sarah H. Watkins, James R. Staley, Gibran Hemani, Thomas Battram, Gemma Crawford, Paul Yousefi, Mahsa Sheikhali Babaei, Tom R. Gaunt, Claire Prince, Charlie Hatcher, Gemma Sharp, Sahar Khodabakhsh, María Jesús Vega-Salas
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, the increase in availability of DNA methylation me
Externí odkaz:
https://doaj.org/article/14ac3ff9c265454984a40484d3a1fd77
Autor:
Ryan Langdon, Matthew Suderman, Oliver Whitehurst, Hannah R. Elliott, Luke Mahoney, Matthew A. Lee, Caroline L. Relton, Giulia Mancano, Abigail C. Lay, Sarah H. Watkins, James R. Staley, Gibran Hemani, Thomas Battram, Gemma Crawford, Paul Yousefi, Mahsa Sheikhali Babaei, Tom R. Gaunt, Claire Prince, Charlie Hatcher, Gemma Sharp, Sahar Khodabakhsh, María Jesús Vega-Salas
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, the increase in availability of DNA methylation me
Externí odkaz:
https://doaj.org/article/65765757317b41d0b21facf330ef8c4e
Autor:
C. Wobus, P. Zheng, J. Stein, C. Lay, H. Mahoney, M. Lorie, D. Mills, R. Spies, B. Szafranski, J. Martinich
Publikováno v:
Earth's Future, Vol 7, Iss 5, Pp 516-527 (2019)
Abstract Inland flood risk in the United States is most often conveyed through maps of 1% annual exceedance probability (AEP) or “100‐year” floodplains. However, monetary damages from flooding arise from a full distribution of events, including
Externí odkaz:
https://doaj.org/article/bb219e4288b24e73bc4a704e014079d5