ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer

Autor: Rebecca Garnham, Daniel Geh, Ryan Nelson, Erik Ramon-Gil, Laura Wilson, Edward N. Schmidt, Laura Walker, Beth Adamson, Adriana Buskin, Anastasia C. Hepburn, Kirsty Hodgson, Hannah Kendall, Fiona M. Frame, Norman Maitland, Kelly Coffey, Douglas W. Strand, Craig N. Robson, David J. Elliott, Rakesh Heer, Matthew Macauley, Jennifer Munkley, Luke Gaughan, Jack Leslie, Emma Scott

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

Abstract Immune checkpoint blockade has yet to produce robust anti-cancer responses for prostate cancer. Sialyltransferases have been shown across several solid tumours, including breast, melanoma, colorectal and prostate to promote immune suppressio

Externí odkaz: https://doaj.org/article/d33390bb279b44abab86eb903fea0a8a

Stable isotope and dental caries data reveal abrupt changes in subsistence economy in ancient China in response to global climate change.

Autor: Christina Cheung, Hua Zhang, Joseph C Hepburn, Dongya Y Yang, Michael P Richards

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0218943 (2019)

Prior to the introduction of wheat and barley from Central Asia during the Neolithic period, northern Chinese agricultural groups subsisted heavily on millet. Despite being the focus of many decades of intensive interest and research, the exact route

Externí odkaz: https://doaj.org/article/7d35a0a4e6f444f7a9a5c68d2874161b

Environmental DNA analysis needs local reference data to inform taxonomy-based conservation policy – A case study from Aotearoa / New Zealand

Autor: M. Ladds, Paul Czechowski, C. Hepburn, M. de Lange, M. Heldsinger, Michael Knapp, William Rayment

Effective management of biodiversity requires regular surveillance of multiple species. Analysis of environmental DNA by metabarcoding (eDNA) holds promise to achieve this relatively easily. However, taxonomic inquiries into eDNA data need suitable m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f42082b3004cf3ee191399bacbb96f83
https://doi.org/10.1101/2021.10.22.465527

Research Imperatives for Future En Route Care

Autor: Byron C Hepburn

Publikováno v: Military medicine. 186(3-4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8674929c27a74042ed93b0f91109eeab
https://pubmed.ncbi.nlm.nih.gov/33399866

Propagation of human prostate tissue from induced pluripotent stem cells

Autor: Omar E. Franco, Anastasia C. Hepburn, Adriana Buskin, Susan E. Crawford, Simon W. Hayward, Ian G. Mills, Luke Gaughan, M Moad, Rakesh Heer, Parmveer Singh, Craig N. Robson, Emma L Curry, Rebecca E Steele, Laura Wilson

Publikováno v: Hepburn, A C, Curry, E L, Moad, M, Steele, R E, Franco, O E, Wilson, L, Singh, P, Buskin, A, Crawford, S E, Gaughan, L, Mills, I G, Hayward, S W, Robson, C N & Heer, R 2020, ' Propagation of human prostate tissue from induced pluripotent stem cells ', Stem cells translational medicine . https://doi.org/10.1002/sctm.19-0286
Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 734-745 (2020)
STEM CELLS Translational Medicine
Stem Cells Translational Medicine

Primary culture of human prostate organoids and patient‐derived xenografts is inefficient and has limited access to clinical tissues. This hampers their use for translational study to identify new treatments. To overcome this, we established a comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb605acdb40354aa09e0646f93a13357
https://doi.org/10.1002/sctm.19-0286